Article
Pharmacology & Pharmacy
Yi-wei Yin, Xiao-qin Liu, Jia-qin Gu, Zi-ran Li, Zheng Jiao
Summary: This study aimed to explore appropriate remedial dosing regimens for non-adherent edoxaban-treated NVAF patients through Monte Carlo simulation. The proposed remedial strategies differed from the current recommendations and were related to the delay time. PK/PD modelling and simulation are effective in developing and evaluating the remedial strategies of edoxaban.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiao-Qin Liu, Yi-Wei Yin, Chen-Yu Wang, Zi-Ran Li, Xiao Zhu, Zheng Jiao
Summary: This study aimed to explore appropriate remedial dosing regimens for non-adherent rivaroxaban-treated patients using a Monte Carlo simulation based on a population pharmacokinetic/pharmacodynamic model. The proposed regimens resulted in shorter deviation time than that of the EHRA guide, providing valid evidence to minimize the risk of bleeding and thromboembolism.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Dung Nguyen, Jafar Sadik Shaik, Guoying Tai, Courtney Tiffany, Caroline Perry, Etienne Dumont, David Gardiner, Aline Barth, Rajendra Singh, Mohammad Hossain
Summary: PBPK and PopPK models were developed to predict effective doses of gepotidacin in pediatric patients for treating pneumonic plague caused by Yersinia pestis. Body weight was identified as a key covariate affecting gepotidacin clearance. The models showed differences in dose predictions based on weight and age, with PopPK potentially suboptimal for very young children due to enzyme maturation considerations.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Clinical Neurology
Yun Kim, Anhye Kim, Jae-Yong Chung
Summary: A population PK/PD model was developed to characterize the delayed QT prolongation effect of escitalopram, with findings suggesting a relatively constant drug effect on QTc change over 24 hours post-dosing. The study provides useful information for monitoring electrocardiograms in patients receiving intensive care after drug administration.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Zi-ran Li, Chen-yu Wang, Wei-wei Lin, Yue-ting Chen, Xiao-qin Liu, Zheng Jiao
Summary: This study aims to explore optimal individualized remedial dosing regimens for delayed or missed doses of commonly used ASMs. Monte Carlo simulation based on population pharmacokinetic models was used to investigate six remedial strategies. The recommended remedial regimens were highly correlated with delayed time, scheduled dosing interval, and half-life of the ASM. The renal function and concomitant medication may also influence the remedial regimens.
Article
Microbiology
Thanh Bach, Daryl J. Murry, Larissa Stebounova, Gregory Deye, Patricia Winokur, Guohua An
Summary: Oxfendazole is a potent veterinary benzimidazole anthelmintic transitioning to human use for the treatment of parasitic diseases. A population pharmacokinetic model was developed to quantitatively capture the relationship between oxfendazole dose and exposure, providing insight into its nonlinear pharmacokinetics and metabolic processes. The model can be used to predict oxfendazole disposition under new dosing regimens to optimize dosing in humans.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Computer Science, Artificial Intelligence
Daehyun Ji, Dokwan Oh, Yoonsuk Hyun, Oh-Min Kwon, Myeong-Jin Park
Summary: This paper investigates the robust training problem of deep neural networks with noisy labels and proposes a novel training method called UACT, which combines uncertainty with clean labels to avoid overfitting issues and achieve good generalization performance.
Article
Engineering, Electrical & Electronic
Meng Chang, Chenwei Yang, Huajun Feng, Zhihai Xu, Qi Li
Summary: A novel method for handling camera motion blur with outliers is proposed in this paper, which utilizes an edge-aware scale-recurrent network and a salient edge detection network for deblurring and edge restoration constraint. Experimental results demonstrate that this method outperforms other existing approaches in terms of deblurring quality.
IEEE TRANSACTIONS ON COMPUTATIONAL IMAGING
(2021)
Article
Clinical Neurology
Drew MacCannell, Zdenek Berger, Lilly East, Eugenio Mercuri, Janbernd Kirschner, Francesco Muntoni, Michelle A. Farrar, Joanna Peng, Jie Zhou, Ivan Nestorov, Wildon Farwell, Richard S. Finkel
Summary: The study elucidated the impact of dosing delays on cerebrospinal fluid concentrations of nusinersen in the treatment of spinal muscular atrophy, emphasizing the importance of promptly resuming the original dosing schedule for maintaining therapeutic efficacy.
NEUROMUSCULAR DISORDERS
(2021)
Article
Chemistry, Medicinal
Tao Xiao, Zhanzhang Wang, Guanlie Li, Shanqing Huang, Xiuqing Zhu, Shujing Liu, Xiaolin Li, Jinqing Hu, Dewei Shang, Yuguan Wen
Summary: This study aimed to investigate remedial regimens for missed doses of olanzapine in elderly patients. Through population pharmacokinetics quantification and simulation prediction, it was found that elderly patients should take the regular dose immediately in a missed dose situation, and the refill dose at the second remedial time point depends on the length of the time delay.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Medicine, General & Internal
Gabor Zoltan Xantus, Derek Burke, Peter Kanizsai
Summary: There is currently no curative drug therapy for COVID-19, and prevention is the only feasible option to stop the pandemic. Anti-vaxxers and conspiracy theorists may continue to undermine efforts to eradicate the virus. Understanding the truth and psychological aspects is crucial in helping the public make informed decisions.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Medicine, General & Internal
Aaron C. Miller, Alan T. Arakkal, Scott Koeneman, Joeseph E. Cavanaugh, Alicia K. Gerke, Douglas B. Hornick, Philip M. Polgreen
Summary: The study identified that many patients with tuberculosis experience multiple missed diagnostic opportunities prior to diagnosis. Missed opportunities most commonly occur in outpatient settings, and various patient, environment, and setting-specific factors increase the risk for delays.
Editorial Material
Clinical Neurology
Samuel W. Terman
Summary: This study aims to explore individualized remedial dosing regimens for delayed or missed doses of commonly used antiseizure medications. Monte Carlo simulation based on population pharmacokinetic models was employed to investigate six remedial strategies. It was found that the recommended remedial regimens were highly correlated to delayed time and the characteristics of the antiseizure medication. A web-based dashboard was developed to provide personalized remedial regimens.
Article
Medicine, General & Internal
Maya Tabet, Russell S. Kirby, Pamela Xaverius
Summary: This study examined the prevalence and factors associated with delayed or missed pediatric preventive care in the US due to the COVID-19 pandemic, with a focus on race and ethnicity. The study found that over one-fourth of children experienced delays or gaps in preventive care. Asian or Pacific Islander, Hispanic, and multiracial children were more likely to experience these delays or gaps, while non-Hispanic White children were less affected. These findings can inform targeted interventions to improve timely pediatric preventive care among different racial and ethnic groups.
Article
Respiratory System
Florian Eichhorn, Hauke Winter
Summary: Patients with oligometastatic lung cancer, defined as having limited metastatic disease, may have better prognosis when treated with local ablative therapy for all lesions. In such cases, surgery and radiotherapy play a dominant role in the treatment course, offering a potentially curative local therapy in combination with systemic treatment based on interdisciplinary decisions.
EUROPEAN RESPIRATORY REVIEW
(2021)
Article
Pharmacology & Pharmacy
Yi-wei Yin, Xiao-qin Liu, Jia-qin Gu, Zi-ran Li, Zheng Jiao
Summary: This study aimed to explore appropriate remedial dosing regimens for non-adherent edoxaban-treated NVAF patients through Monte Carlo simulation. The proposed remedial strategies differed from the current recommendations and were related to the delay time. PK/PD modelling and simulation are effective in developing and evaluating the remedial strategies of edoxaban.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yueting Chen, Yang Yang, Shansen Xu, Chenyu Wang, Pan Shu, Xiaoyu Zhang, Qin Huang, Jin Sook Kim, Zheng Jiao
Summary: This study aimed to develop population pharmacokinetics and pharmacodynamics (popPK/PD) models of SIM0295 and explore potential covariates to inform clinical drug development. SIM0295 pharmacokinetics was described using a two-compartment model with the absorption of four transit compartments and first-order elimination. The established popPK/PD model characterized the dose-exposure-response relationship for SIM0295 in healthy subjects and patients with gout and hyperuricemia and could be used to inform the drug development.
EXPERT OPINION ON INVESTIGATIONAL DRUGS
(2023)
Letter
Gastroenterology & Hepatology
Danna Wu, Guo Yu, Guo-fu Li
Letter
Oncology
Guo Yu, Na Zhang, Ai-Jia Guan, Yu-Wei Qiao, Guo-Fu Li
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jinmeng Li, Xinjun Cai, Yueting Chen, Chenyu Wang, Zheng Jiao
Summary: Isoniazid (INH) plays a vital role in tuberculosis (TB) prevention and treatment, but there are significant pharmacokinetic variations in patients receiving standard dosages. This review explores the population pharmacokinetic studies of INH and identifies significant covariates that affect INH pharmacokinetics. The findings suggest that fast metabolizers require a higher daily dose of INH compared to slow metabolizers, and pediatric patients need a higher dose per kilogram than adults. Further pharmacokinetic studies are needed to accurately adjust the dosage for anti-tuberculosis drugs.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jue-Hui Mao, Lu Han, Xiao-Qin Liu, Zheng Jiao
Summary: This review provides an overview of published population pharmacokinetic studies on olanzapine and explores factors contributing to its pharmacokinetic variability. The results showed that the apparent clearance in adults was 0.253 L/h/kg, 27-43% lower than in infants and children. Men and smokers had higher apparent clearance, increasing it by 32% and 34% respectively. Furthermore, further population studies are needed to clarify the dose-exposure-response relationship of olanzapine.
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xiao-Qin Liu, Zi-Ran Li, Chen-Yu Wang, Yue-Ting Chen, Zheng Jiao
Summary: This review investigated the potential ethnic differences in the pharmacokinetic and pharmacodynamic characteristics of rivaroxaban between Asians and Caucasians. The findings suggest that Asians may require a lower dose of rivaroxaban compared to Caucasians. Further studies are needed to confirm this ethnic difference and optimize dosing regimens.
Article
Health Care Sciences & Services
Yi-Fan Cui, Yan Pan, Min-Fang Zhu, Zheng Jiao
Summary: This study aimed to investigate the pharmacokinetics of tacrolimus and the influential factors in Chinese patients after lung transplantation. The results showed a significant correlation between CYP3A5*3 genetic polymorphisms and the pharmacokinetics of tacrolimus.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Letter
Medicine, General & Internal
Dan -Na Wu, Ai-Jia Guan, Guo-Fu Li
Editorial Material
Pharmacology & Pharmacy
Xiang Chen, Guo Yu, Guo-Fu Li
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
(2023)
Article
Pharmacology & Pharmacy
Zhe Tang, Jing Guan, Jue-hui Mao, Lu Han, Juan-juan Zhang, Rui Chen, Zheng Jiao
Summary: This study quantitatively evaluated and compared the effects of oral contraceptives, insulin sensitizers, and antiandrogens for treating polycystic ovary syndrome. The results showed that oral contraceptives performed well in improving menstruation, hirsutism score, and free androgen index, but elevated triglyceride levels. Metformin had a slight BMI-lowering effect, and lifestyle intervention with placebo significantly decreased BMI. Antiandrogens had weaker effects in reducing hirsutism score and free androgen index compared to oral contraceptives. Individualized pharmacotherapies based on baseline measurements achieved more clinical improvements. Further research is needed on long-term risk-benefit profiles and emerging therapies.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Letter
Gastroenterology & Hepatology
Guo-Fu Li, Guo Yu
Letter
Oncology
Danna Wu, Guo-Fu Li
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Infectious Diseases
Yan Qin, Zheng Jiao, Yan-Rong Ye, Yun Shen, Zhe Chen, Yue-Ting Chen, Xiao-Yu Li, Qian-Zhou Lv
Summary: This study aimed to evaluate the predictive performance of published pharmacokinetic models of linezolid in adult patients. The results showed that these models exhibited insufficient predictive ability, indicating the necessity of incorporating therapeutic drug monitoring of linezolid in clinical applications.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)