Article
Immunology
Patricia Ramos-Ramirez, Carina Malmhall, Omar Tliba, Madeleine Radinger, Apostolos Bossios
Summary: Adiponectin/AdipoR1 axis promotes IL-10 release by Tregs, mainly in Helios(-) Tregs, and the effect was amplified by T2 inflammation in Helios(+) Tregs. This suggests a potential role of adiponectin in regulating Treg function in human inflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Chemistry, Applied
Xinyu Bai, Ping Liu, Hengyan Shen, Qiaoyue Zhang, Tao Zhang, Xuejun Jin
Summary: WLJP was found to improve allergic rhinitis through various mechanisms, such as reducing inflammation levels, modulating immune responses, maintaining gut microbiota balance, repairing damaged barriers, and alleviating AR symptoms. Additionally, significant interaction between WLJP and the NLRP3 inhibitor CY-09 was observed.
CARBOHYDRATE POLYMERS
(2022)
Article
Immunology
Jinqiu Jiang, Tao Qin, Liang Zhang, Qiao Liu, Jiabin Wu, Rongxin Dai, Lina Zhou, Qin Zhao, Xiaoyan Luo, Hua Wang, Xiaodong Zhao
Summary: Deficiencies in DOCK8 result in quantitative and qualitative defects in IL-10-producing Breg cells, potentially due to abnormal Dock8(-/-) CD4(+) T cells. The study found that recombinant murine IL-21 can restore Bregs function and reduce inflammatory cell infiltration in the lung in a murine asthma model. This provides new insights into potential therapeutic strategies for allergic diseases, such as asthma associated with DOCK8 deficiency.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Anett Mazlo, Ramona Kovacs, Noemi Miltner, Marta Toth, Zoltan Vereb, Krisztina Szabo, Ildiko Bacskai, Kitti Pazmandi, Agota Apati, Tamas Biro, Krisztian Bene, Eva Rajnavolgyi, Attila Bacsi
Summary: Findings suggest that MSCl cells promote differentiation of CTLA-4 expressing DCs through the production of all-trans retinoic acid, leading to the activation and polarization of allogeneic, naive T cells by semi-matured DCs in a CTLA-4 dependent manner. Understanding the molecular mechanisms behind MSC-mediated modulation of DC differentiation may expand the clinical application of MSCs in cell-free therapies.
Article
Allergy
Sofia Tagkareli, Maria Salagianni, Ioanna-Evdokia Galani, Maria Manioudaki, Eleftherios Pavlos, Kalliopi Thanopoulou, Evangelos Andreakos
Summary: The study identified a novel regulatory T-cell population expressing CD103, which is programmed to prevent excessive type 2 inflammation and maintain homeostasis in the respiratory tract. This has important therapeutic implications for allergic and autoimmune disorders.
Article
Immunology
Anna Sophie Thomann, Theresa Schneider, Laura Cyran, Ina Nathalie Eckert, Andreas Kerstan, Manfred B. Lutz
Summary: The study illustrates the induction of anergic CD4(+) T cells in vivo through high doses of antigen, converting them into suppressive Foxp3(-) IL-10(+) Tr1 cells. The up-regulation kinetics of several markers and the necessity for transient intracellular CTLA-4 expression in the conversion process are discussed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Claire Barbieux, Mathilde Bonnet des Claustres, Matthias Fahrner, Evgeniya Petrova, Lam C. Tsoi, Olivier Gouin, Florent Leturcq, Pascale Nicaise-Roland, Christine Bole, Vivien Beziat, Emmanuelle Bourrat, Oliver Schilling, Johann E. Gudjonsson, Alain Hovnanian
Summary: This study comprehensively characterizes the skin, immune cells, and allergic phenotypes of Netherton syndrome through multiple molecular profiling methods. The results reveal abnormal epidermal proliferation and differentiation, as well as IL-17/IL-36 signatures in both NS-ILC and NS-SE. Distinct molecular features are found between nonlesion and lesion skin of each disease subtype. Serum cytokine profiling and immunophenotyping show different allergic responses in NS-ILC and NS-SE patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Hong Ki Min, Sehee Kim, Ji-Yeon Lee, Kyoung-Woon Kim, Sang-Heon Lee, Hae-Rim Kim
Summary: Patients with rheumatoid arthritis (RA) have higher levels of interleukin-18 (IL-18) and lower levels of IL-18 binding protein (IL-18BP) in their serum and synovial fluid compared to those with osteoarthritis (OA) or healthy controls. In vitro studies show that IL-18BP can correct the Th17/Treg imbalance in CD4(+) T cells of RA patients and reduce IL-17-induced osteoclastogenesis, suggesting therapeutic potential for RA treatment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Allergy
Yu Zhang, Yujuan Yang, Jing Guo, Limei Cui, Liping Yang, Yumei Li, Yakui Mou, Chuanliang Jia, Luo Zhang, Xicheng Song
Summary: The study found that expression levels of miR-146a and STAT5b were significantly lower in the nasal mucosa or PBMCs of AR patients compared to the control group. There were fewer Tregs in miR-146a knockdown or STAT5b knockdown PBMCs, and miR-146a positively targeted STAT5b to enhance Treg differentiation and function in AR.
Article
Pharmacology & Pharmacy
Manabu Kitano, Seiya Fukuoka, Naoki Adachi, Tadashi Hisamitsu, Masataka Sunagawa
Summary: Shoseiryuto (SST), a traditional herbal medicine, alleviates symptoms of toluene diisocyanate (TDI)-induced allergic rhinitis (AR) and inhibits IL-33 release from nasal epithelial cells.
Article
Multidisciplinary Sciences
Wojciech Dawicki, Hui Huang, Yanna Ma, Jennifer Town, Xiaobei Zhang, Chris D. Rudulier, John R. Gordon
Summary: CD40 signaling in DC10 plays a crucial role in promoting IL-10 expression and robust induction of tolerance, including activation of induced Treg.
Article
Dermatology
Abate Assefa Bashaw, Chenhao Zhou, Meihua Yu, Lynn Tolley, Graham R. Leggatt, Ian H. Frazer, Janin Chandra
Summary: HPV16 E7-induced epithelial hyperplasia promotes peripheral Treg expansion in response to intradermal immunization, suppressing antigen-specific CD8+ T-cell responses independently of IL-10. Depletion of these Tregs is not sufficient to restore T helper type 1 immunity.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biology
Oksana Tsyklauri, Tereza Chadimova, Veronika Niederlova, Jirina Kovarova, Juraj Michalik, Iva Malatova, Sarka Janusova, Olha Ivashchenko, Helene Rossez, Ales Drobek, Hana Vecerova, Virginie Galati, Marek Kovar, Ondrej Stepanek
Summary: In this study, it was identified that Tregs limit the availability of IL-2, thereby suppressing the formation of a previously uncharacterized subset of antigen-stimulated KILR CD8(+) effector T cells. These KILR CD8(+) T cells exhibit superior cell-killing abilities and can be induced by the administration of agonistic IL-2 immunocomplexes. This research has potential implications for immunotherapy targeting these cells in humans.
Article
Cell Biology
Daniele Avancini, Alessandro Testori, Lucia Fresolone, Grazia Andolfi, Michela Vuono, Vittorio Martinelli, Francesca R. Santoni de Sio, Silvia Gregori
Summary: IL-10 induces the generation of tolerogenic dendritic cells (tolDC) from monocytes through the activation of aryl hydrocarbon receptor (AHR). AHR activity downstream of IL-10 signaling is required for the induction of tolerogenic activities in DCs, and this IL-10/AHR genomic signature is active in circulating DCs in healthy individuals. However, in multiple sclerosis patients, an altered IL-10/AHR signature is observed, which correlates with functional defects and reduced frequencies of IL-10-induced tolDCs in vitro and in vivo.
Article
Neurosciences
Ayhan Bilgic, Sedat Abusoglu, Cagla Sadic celikkol, Mehmet Burhan Oflaz, Omer Faruk Akca, Abdullah Sivrikaya, Tamer Baysal, Ali Unlu
Summary: This study aimed to investigate kynurenine pathway metabolite levels, enzyme activities, and neuroprotective index in toddlers and preschool children with ASD. The results showed significantly higher serum 3-hydroxykynurenine and kynurenic acid concentrations in the ASD group compared to controls, indicating a potential role of the kynurenine pathway in the etiopathogenesis of ASD in early childhood.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ibrahim Ugurlu, Saltuk Bugra Baltaci, Omer Unal, Rasim Mogulkoc, Hulya Ucaryilmaz, Abdulkerim Kasim Baltaci
Summary: The study found that chronic exercise partially improves NK and NKT cell percentages in diabetic rats, while significantly increasing ZIP10 levels in spleen and thymus tissue. This suggests that regular exercise can help correct impaired immune function and restore suppressed ZIP10 levels in diabetic rats.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Mehmet Sozen, Suleyman Baldane, Sedat Abusoglu, Levent Kebapcilar, Aysegul Kebapcilar, Fatma Tuncez Akyurek, Ali Unlu, Suleyman Hilmi Ipekci
Summary: The study aimed to evaluate cardiovascular and metabolic effects in men with male pattern alopecia beginning before 30 years of age. Results showed that AGA patients are similar to the normal population in terms of insulin resistance or metabolic syndrome components, but hsCRP and galectin-3 may be associated with cardiovascular disease risk factors in individuals with AGA.
Article
Medicine, General & Internal
Zekiye Soykan Sert, Setenay Arzu Yilmaz, Ozlem Secilmis, Sedat Abusoglu, Ali Unlu, Cetin Celik
Summary: This study investigated the effect of calcium and vitamin D supplementation on PCOS patients. It found that Ca/Vit D supplementation can improve PCOS symptoms and reduce the risk of cardiovascular disease in these patients.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Duygu Eryavuz Onmaz, Dilek Tezcan, Sedat Abusoglu, Abdullah Sivrikaya, Menekse Kuzu, Fatma Humeyra Yerlikaya, Sema Yilmaz, Ali Unlu
Summary: This study found that KP metabolite levels were elevated in patients with BD, and there is a relationship between these metabolites with disease activity, clinical findings, and inflammatory burden.
Article
Immunology
Fatih Hilmi Cetin, Huelya Ucaryilmaz, Halit Necmi Ucar, Hasibe Artac, Hasan Ali Guler, Sevde Afife Duran, Kuebra Kilinc, Serhat Turkoglu
Summary: The pathophysiology of ADHD is not fully understood, but immune system dysregulation has been identified as a major focus. This study found that children with ADHD had significantly higher levels of Tregs compared to healthy controls, indicating a potential association with ADHD and suggesting that immune regulatory cells may play a key role in ADHD treatment.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Article
Medical Laboratory Technology
Duygu Eryavuz Onmaz, Dilek Tezcan, Sedat Abusoglu, Firdevs Sak, Fatma Humeyra Yerlikaya, Sema Yilmaz, Gulsum Abusoglu, Muslu Kazim Korez, Ali Unlu
Summary: This study measured serum KP metabolite concentrations in patients with pSS and evaluated their relationship with disease activity score and clinical manifestations. The results showed that KYN and QUIN levels were significantly higher in patients with pSS, while TRP, KYNA/KYN and 3HK/KYN levels were lower. The study also found a positive correlation between KYN/TRP ratio and disease activity, and a negative correlation between KYNA/KYN ratio and disease activity.
CLINICAL BIOCHEMISTRY
(2023)
Article
Mycology
Merve Aydin, Ali Ozturk, Tugce Duran, Ummuhan Ozdemir Ozmen, Esra Sumlu, Esra Bilen Ayan, Emine Nedime Korucu
Summary: This study synthesized a series of new sulfo-nyl hydrazones compound and demonstrated their antifungal and biofilm inhibitory activity. The results suggest that Anaf compounds may have potential therapeutic applications in the treatment and prevention of biofilm-associated Candida infections.
JOURNAL DE MYCOLOGIE MEDICALE
(2023)
Article
Cell Biology
D. Soyler, E. N. Korucu, E. Menevse, A. A. Azzawri, D. E. Kaya
Summary: The study aimed to investigate the effects of curcumin and juglone on cell viability, anticancer activity, cytotoxicity, and changes in FABP5 and FABP9 gene expression and protein levels in breast cancer cell lines MCF-7 and MDA-MB-231. The results showed that curcumin and juglone decreased cell viability, expression of FABP5 and FABP9 genes, and levels of FABP5 and FABP9 proteins in MCF-7 cells. In MDA-MB-231 cells, low doses of curcumin and juglone increased FABP5 and FABP9 levels, while high doses decreased them.
BIOCHEMISTRY MOSCOW SUPPLEMENT SERIES A-MEMBRANE AND CELL BIOLOGY
(2023)
Article
Otorhinolaryngology
Buelent Ulusoy, Serdar Ugras, Vedat Uslu, Cagdas Elsurer, Muslu Kazim Korez
Summary: The effectiveness of using polypropylene mesh and platelet-rich fibrin (PRF) in repairing nasal septal perforation (NSP) was investigated. The results showed that the success rate of NSP treatment was significantly higher in the groups using polypropylene mesh and polypropylene mesh + PRF compared to the control group.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Pharmacology & Pharmacy
Emine Nedime Korucu, Ali Unlu
Summary: Vitamin D treatment inhibited the proliferation and invasion of breast cancer cells in a dose and time dependent manner, and also decreased uPA activity and energy levels.
ISTANBUL JOURNAL OF PHARMACY
(2022)
Article
Biochemistry & Molecular Biology
Saadet Kader, Turan Akdag, Busra Ecer, Sedat Abusoglu, Ali Unlu
Summary: The study compared the performance of four methods for determining 25(OH)D levels, with the Roche Cobas assay showing better performance compared to LC-MS/MS.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
Article
Biochemistry & Molecular Biology
Ahmet Ercan Hataysal, Ali Unlu, Esra Paydas Hataysal, Sedat Abusoglu, Nimet Unlu
Summary: Salivary levels of total antioxidant capacity (TAC), total oxidant status (TOS), and visfatin were found to be significantly higher in patients with dental caries compared to caries-free individuals. There was a positive correlation between the number of caries and salivary TOS and visfatin levels. This study suggests that oxidative stress may play a role in the pathogenesis of dental caries, and salivary visfatin, TAC, and TOS could be novel markers for evaluating dental caries.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
Review
Biochemistry & Molecular Biology
Ali Unlu, Sedat Abusoglu
Summary: Mass spectrometric methods are widely used in clinical laboratories, particularly in the fields of metabolic analysis and protein studies, playing a crucial role in various applications.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2022)
Article
Pediatrics
Ayca Emsen, Hulya Ucaryilmaz, Tugba Guler, Hasibe Artac
Summary: This study investigated the role of T and B cell subsets in the pathogenesis of transient hypogammaglobulinemia of infancy (THI). Findings showed increased Tregs and decreased primarily memory B cells in THI patients, suggesting a delay in antibody production.
TURKISH JOURNAL OF PEDIATRICS
(2022)
