Article
Medicine, Research & Experimental
Lutfun Nahar, Hideharu Hagiya, Takahiro Nada, Koji Iio, Kazuyoshi Gotoh, Osamu Matsushita, Fumio Otsuka
Summary: This study investigated the frequency and genotypic profiles of inducible resistance to macrolide, lincosamide, and streptogramin B (iMLSB) antibiotics in clindamycin-susceptible Staphylococcus aureus isolates. The results showed that approximately 33% of the isolates exhibited iMLSB resistance, predominantly caused by the ermA gene.
ACTA MEDICA OKAYAMA
(2023)
Article
Dermatology
Sahya Koyanagi, Juri Koizumi, Keisuke Nakase, Nobukazu Hayashi, Yuki Horiuchi, Kaoru Watanabe, Toshiya Asai, Akiko Yamazaki, Emi Nakazaki, Hidemasa Nakaminami
Summary: This study aimed to analyze the antimicrobial resistance of Cutibacterium acnes strains isolated from Japanese patients with acne vulgaris. The results showed an increasing prevalence of antimicrobial-resistant strains, highlighting the importance of selecting appropriate antimicrobials based on the latest information on resistant strains for effective treatment.
JOURNAL OF DERMATOLOGY
(2023)
Article
Infectious Diseases
Haiping Wang, Hemu Zhuang, Shujuan Ji, Lu Sun, Feng Zhao, Dandan Wu, Ping Shen, Yan Jiang, Yunsong Yu, Yan Chen
Summary: The study revealed high rates of erythromycin and clindamycin resistance among different MRSA lineages in China, with varying resistance patterns and frequent presence of specific resistance genes in certain MRSA clones. Detection of resistance genes transfer between MRSA isolates in healthcare settings remains an issue, emphasizing the need for infection control measures.
INFECTION GENETICS AND EVOLUTION
(2021)
Article
Infectious Diseases
Aya A. Mahfouz, Heba S. Said, Sherin M. Elfeky, Mona I. Shaaban
Summary: The increasing prevalence of erythromycin and erythromycin-induced clindamycin resistance in Staphylococcus aureus infection is a serious concern. This study identified the prevalence of resistance phenotypes and corresponding genes, and evaluated potential inhibitors. Several compounds were found to reduce erythromycin resistance and combat inducible clindamycin resistance. The findings emphasize the importance of managing antibiotic resistance and provide potential inhibitors for further investigation.
Article
Multidisciplinary Sciences
Viktoria Lazar, Olga Snitser, Daniel Barkan, Roy Kishony
Summary: The study finds that combinations of antibiotics have different effects on long-term bacterial clearance, often showing reciprocal suppression. The efficacy of clearance decreases as more drugs are added, except for specific drugs targeting non-growing persisters. Competition experiments show that reciprocal suppressive drug combinations can select against resistance, even against methicillin-resistant Staphylococcus aureus. Therefore, systematically studying the long-term clearance efficacy of drug combinations is crucial for designing more effective and resistance-proof multidrug regimens.
Article
Medicine, Research & Experimental
Roshan Timsina, Upasana Shrestha, Anjana Singh, Bivek Timalsina
Summary: The study in Nepal found that methicillin-resistant Staphylococcus aureus (MRSA) is prevalent among school children, with a significant number also showing inducible clindamycin resistance. The presence of ermC, ermB, and ermA genes in MRSA strains indicates the need for further investigation into the mechanisms of resistance in this population.
Article
Microbiology
Jiahong Zhang, Zhuo Wang, Hsin-Yao Wang, Chia-Ru Chung, Jorng-Tzong Horng, Jang-Jih Lu, Tzong-Yi Lee
Summary: In this study, a dual resistance prediction model was constructed based on MALDI-TOF spectra data for rapid prediction of sensitivity to oxacillin and clindamycin in Staphylococcus aureus-infected patients. The model showed good performance in terms of accuracy, area under the receiver characteristic curve, and provides guidance in antibiotic usage.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Maryam Shahid, Riaz Hussain, Zeeshan Nawaz, Bilal Aslam, Muhammad Zishan Ahmad, Abu Baker Siddique, Hira Ahsan, Aiman Fatima, Iahtasham Khan, Bilal Mustafa, Rashid Iqbal, Khalid M. Al Syaad, Ashwag Shami
Summary: The occurrence of Staphylococcus aureus-induced subclinical mastitis has significant implications for public health. This study found a high prevalence of this bacterium in dairy cows, as well as antimicrobial resistance and multiple virulence genes.
Review
Genetics & Heredity
Mojtaba Memariani, Hamed Memariani, Hamideh Moravvej
Summary: The overall prevalence of iMLS(B) phenotype in clinical S. aureus strains in Iran was found to be 10.40%, with these strains commonly encountered in wound and blood samples. The prevalence of iMLS(B) strains in S. aureus was higher than that of MRSA. Further nationwide surveillance studies are urgently needed to evaluate these strains.
Article
Agriculture, Dairy & Animal Science
Sonsiray Alvarez Narvaez, Ingrid Fernandez, Nikita V. Patel, Susan Sanchez
Summary: In this study, a multiplex qPCR diagnostic tool was developed for the simultaneous detection of R. equi and related antibiotic resistance genes in equine respiratory samples. The tool showed high sensitivity and specificity, and had good performance in in-silico analysis, demonstrating its potential to improve the speed of R. equi infection diagnosis and treatment selection.
Article
Medicine, General & Internal
Shahnaz Armin, Abdollah Karimi, Zahra Pourmoghaddas, Leila Azimi, Fatemeh Fallah, Sahel Valadan Tahbaz
Summary: This study evaluated the frequency of virulence genes and antibiotic susceptibility of MRSA in 695 Staphylococcus clinical samples from seven provinces in Iran. The results showed significant resistance of MRSA to clindamycin and ciprofloxacin, which may be due to the hlb virulence gene. The findings cannot be used as a guide for local antibiotic usage due to the diversity of MRSA samples isolated from both community-acquired and healthcare-associated sources.
JOURNAL OF RESEARCH IN MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Niluka Dilrukshi, Jananie Kottahachchi, Thushari Dissanayake, Neluka Fernando
Summary: This study assessed the antibiotic susceptibility and characterized antibiotic resistance genes of GBS isolates from selected tertiary care hospitals in Western province, Sri Lanka. GBS colonization rate in the study sample was 25.7%, with all isolates being sensitive to penicillin. The most prevalent resistance genotype was ermTR.
MEDICAL PRINCIPLES AND PRACTICE
(2023)
Article
Infectious Diseases
Vincenzo Pennone, Miguel Prieto, Avelino Alvarez-Ordonez, Jose F. Cobo-Diaz
Summary: This study analyzed publicly available genomes of Staphylococcus aureus and identified different antimicrobial resistance genes (ARGs) in chromosomes and plasmids. Differences in the distribution of ARGs and clonal complexes (CC) were observed among continents. Temporal changes over the past 20 years showed a decrease in MRSA and macrolide resistance occurrence in plasmids, while the occurrence of ARGs associated with aminoglycoside resistance increased.
Article
Medicine, General & Internal
Nisha Goyal, Narendra Pal Singh
Summary: This study evaluated the agreement between the test method using azithromycin disk and the reference method using erythromycin disk in detecting inducible clindamycin resistance, and determined the prevalence of inducible clindamycin-resistant phenotypes among Staphylococcus aureus isolates. A total of 133 S. aureus isolates were included in this prospective study. The agreement between the reference and test methods for detecting inducible clindamycin-resistant phenotypes was 100%. For the determination of constitutive-resistant phenotypes among S. aureus isolates, the test method demonstrated an agreement of 94.1%.
JOURNAL OF LABORATORY PHYSICIANS
(2023)
Article
Plant Sciences
Youssef E. Abdelmawgoud, Walaa Abd El-Latif, Nouran K. Fawzy, Sherif M. Elnagdy
Summary: This study investigated the prevalence of ICR among clinical isolates of S. aureus and examined the antibacterial effects of silver nanoparticles (AgNPs) alone and in combination with clindamycin against these isolates. The results demonstrated strong antibacterial activity of AgNPs against S. aureus, with potential as a treatment for infections caused by this pathogen.
EGYPTIAN JOURNAL OF BOTANY
(2022)