Metal Bioavailability Models: Current Status, Lessons Learned, Considerations for Regulatory Use, and the Path Forward

Systematic analysis of freshwater metal toxicity with WHAM-FTOX

(2019) E. Tipping et al.   AQUATIC TOXICOLOGY

Development of Empirical Bioavailability Models for Metals

(2019) Kevin V. Brix et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Bioavailability Assessment of Metals in Freshwater Environments: A Historical Review

(2019) William Adams et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Validation of Bioavailability‐Based Toxicity Models for Metals

(2019) Emily R. Garman et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Best Practices for Derivation and Application of Thresholds for Metals Using Bioavailability‐Based Approaches

(2019) Eric Van Genderen et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Chronic Toxicity of Binary Mixtures of Six Metals (Ag, Cd, Cu, Ni, Pb, and Zn) to the Great Pond Snail Lymnaea stagnalis

(2018) Anne Crémazy et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Protectiveness of Cu water quality criteria against impairment of behavior and chemo/mechanosensory responses: An update

(2018) Joseph S. Meyer et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

A framework for ecological risk assessment of metal mixtures in aquatic systems

(2018) Charlotte Nys et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Use of Multiple Linear Regression Models for Setting Water Quality Criteria for Copper: A Complementary Approach to the Biotic Ligand Model

(2017) Kevin V. Brix et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Systematic Evaluation of Chronic Metal-Mixture Toxicity to Three Species and Implications for Risk Assessment

(2017) Charlotte Nys et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Multiple linear regression models for predicting chronic aluminum toxicity to freshwater aquatic organisms and developing water quality guidelines

(2017) David K. DeForest et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Comparison of four methods for bioavailability-based risk assessment of mixtures of Cu, Zn, and Ni in freshwater

(2017) Tina Van Regenmortel et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Refinement and cross-validation of nickel bioavailability in PNEC-Pro, a regulatory tool for site-specific risk assessment of metals in surface water

(2017) Anja J. Verschoor et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The mechanisms of nickel toxicity in aquatic environments: An adverse outcome pathway analysis

(2017) Kevin V. Brix et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Development and application of a biotic ligand model for predicting the chronic toxicity of dissolved and precipitated aluminum to aquatic organisms

(2017) Robert C. Santore et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Development of biotic ligand model-based freshwater aquatic life criteria for lead following US Environmental Protection Agency guidelines

(2017) David K. DeForest et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Effect of temperature on chronic toxicity of copper, zinc, and nickel to Daphnia magna

(2017) Cecília M.S. Pereira et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Acute dysprosium toxicity to Daphnia pulex and Hyalella azteca and development of the biotic ligand approach

(2016) Oliver Vukov et al.   AQUATIC TOXICOLOGY

Interactions of waterborne and dietborne Pb in rainbow trout, Oncorhynchus mykiss: Bioaccumulation, physiological responses, and chronic toxicity

(2016) Derek Alsop et al.   AQUATIC TOXICOLOGY

Investigating copper toxicity in the tropical fish cardinal tetra ( Paracheirodon axelrodi ) in natural Amazonian waters: Measurements, modeling, and reality

(2016) Anne Crémazy et al.   AQUATIC TOXICOLOGY

Characterization of the effects of binary metal mixtures on short-term uptake of Ag, Cu, and Ni by rainbow trout ( Oncorhynchus mykiss )

(2016) Kevin V. Brix et al.   AQUATIC TOXICOLOGY

Zinc toxicity to the alga Pseudokirchneriella subcapitata decreases under phosphate limiting growth conditions

(2016) C. Gao et al.   AQUATIC TOXICOLOGY

When are metal complexes bioavailable?

(2016) Chun-Mei Zhao et al.   Environmental Chemistry

Determination of cupric ion concentrations in marine waters: an improved procedure and comparison with other speciation methods

(2016) Tara N. Tait et al.   Environmental Chemistry

Dietary Uptake of Cu Sorbed to Hydrous Iron Oxide is Linked to Cellular Toxicity and Feeding Inhibition in a Benthic Grazer

(2016) Daniel J. Cain et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The effect of pH on chronic aquatic nickel toxicity is dependent on the pH itself: Extending the chronic nickel bioavailability models

(2016) Charlotte Nys et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

The derivation of effects threshold concentrations of lead for European freshwater ecosystems

(2016) Patrick A. Van Sprang et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Does the scientific underpinning of regulatory tools to estimate bioavailability of nickel in freshwaters matter? The European-wide environmental quality standard for nickel

(2016) Adam Peters et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Larval aquatic insect responses to cadmium and zinc in experimental streams

(2016) Christopher A. Mebane et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Dissolved organic carbon from the upper Rio Negro protects zebrafish (Danio rerio) against ionoregulatory disturbances caused by low pH exposure

(2016) Rafael M. Duarte et al.   Scientific Reports

Interactive effects of waterborne metals in binary mixtures on short-term gill–metal binding and ion uptake in rainbow trout (Oncorhynchus mykiss)

(2015) Som Niyogi et al.   AQUATIC TOXICOLOGY

Evaluation of current copper bioavailability tools for soft freshwaters in Sweden

(2015) S. Hoppe et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Soft and sour: The challenge of setting environmental quality standards for bioavailable metal concentration in Fennoscandinavian freshwaters

(2015) Sabina Hoppe et al.   ENVIRONMENTAL SCIENCE & POLICY

Metal Mixture Modeling Evaluation project: 3. Lessons learned and steps forward

(2015) Kevin J. Farley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Testing WHAM-FTOXwith laboratory toxicity data for mixtures of metals (Cu, Zn, Cd, Ag, Pb)

(2015) Edward Tipping et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Metal Mixtures Modeling Evaluation project: 1. Background

(2015) Joseph S. Meyer et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Comparison of the capacity of two biotic ligand models to predict chronic copper toxicity to twoDaphnia magnaclones and formulation of a generalized bioavailability model

(2015) Tina Van Regenmortel et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Expanding metal mixture toxicity models to natural stream and lake invertebrate communities

(2015) Laurie S. Balistrieri et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Metal Mixture Modeling Evaluation project: 2. Comparison of four modeling approaches

(2015) Kevin J. Farley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Acclimation and Deacclimation of Brown Trout (Salmo trutta) to Zinc and Copper Singly and in Combination with Cadmium or Copper

(2014) Stephen F. Brinkman et al.   ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY

Critical Review: Toxicity of Dietborne Metals to Aquatic Organisms

(2014) David K. DeForest et al.   CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY

Lead toxicity toLemna minorpredicted using a metal speciation chemistry approach

(2014) Paula M.C. Antunes et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Metal mixture toxicity to aquatic biota in laboratory experiments: Application of the WHAM-FTOX model

(2013) E. Tipping et al.   AQUATIC TOXICOLOGY

Development and validation of a biotic ligand model for predicting chronic toxicity of lead toCeriodaphnia dubia

(2013) Charlotte Nys et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Predicting the toxicity of metal mixtures

(2013) Laurie S. Balistrieri et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Cadmium bioavailability to Hyalella azteca from a periphyton diet compared to an artificial diet and application of a biokinetic model

(2012) Lisa A. Golding et al.   AQUATIC TOXICOLOGY

Effects of Continuous Copper Exposure and Calcium on the Olfactory Response of Fathead Minnows

(2012) William A. Dew et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Application of U.S. EPA guidelines in a bioavailability-based assessment of ambient water quality criteria for zinc in freshwater

(2012) David K. DeForest et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

THE INFLUENCE OF pH ON ALGAL CELL MEMBRANE PERMEABILITY AND ITS IMPLICATIONS FOR THE UPTAKE OF LIPOPHILIC METAL COMPLEXES1

(2012) Michel Lavoie et al.   JOURNAL OF PHYCOLOGY

Assessing time-integrated dissolved concentrations and predicting toxicity of metals during diel cycling in streams

(2012) Laurie S. Balistrieri et al.   SCIENCE OF THE TOTAL ENVIRONMENT

The two faces of DOC

(2011) Chris M. Wood et al.   AQUATIC TOXICOLOGY

Evaluating the ameliorative effect of natural dissolved organic matter (DOM) quality on copper toxicity to Daphnia magna: improving the BLM

(2011) Hassan A. Al-Reasi et al.   ECOTOXICOLOGY

Assessing WHAM/Model VII against field measurements of free metal ion concentrations: model performance and the role of uncertainty in parameters and inputs

(2011) Stephen Lofts et al.   Environmental Chemistry

Humic Ion-Binding Model VII: a revised parameterisation of cation-binding by humic substances

(2011) E. Tipping et al.   Environmental Chemistry

Development of biotic ligand models for chronic manganese toxicity to fish, invertebrates, and algae

(2011) Adam Peters et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Influence of dissolved organic carbon on toxicity of copper to a unionid mussel (Villosa iris) and a cladoceran (Ceriodaphnia dubia) in acute and chronic water exposures

(2011) Ning Wang et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Development of a biotic ligand model to predict the acute toxicity of cadmium to Daphnia pulex

(2010) Matthew Clifford et al.   AQUATIC TOXICOLOGY

Toxicity of proton–metal mixtures in the field: Linking stream macroinvertebrate species diversity to chemical speciation and bioavailability

(2010) Anthony Stockdale et al.   AQUATIC TOXICOLOGY

Diel biogeochemical processes and their effect on the aqueous chemistry of streams: A review

(2010) David A. Nimick et al.   CHEMICAL GEOLOGY

A review of the influence of low ambient calcium concentrations on freshwater daphniids, gammarids, and crayfish

(2010) Allegra Cairns et al.   ENVIRONMENTAL REVIEWS

Can the Biotic Ligand Model Predict Cu Toxicity Across a Range of pHs in Softwater-Acclimated Rainbow Trout?

(2010) Tania Y.-T. Ng et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Integration of Biotic Ligand Models (BLM) and Bioaccumulation Kinetics into a Mechanistic Framework for Metal Uptake in Aquatic Organisms

(2010) Karin Veltman et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Copper Binding Dynamics and Olfactory Impairment in Fathead Minnows (Pimephales promelas)

(2010) Warren W. Green et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Relationship between biotic ligand model-based water quality criteria and avoidance and olfactory responses to copper by fish

(2010) Joseph S. Meyer et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Cross-species extrapolation of chronic nickel Biotic Ligand Models

(2010) Christian E. Schlekat et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Protectiveness of water quality criteria for copper in western United States waters relative to predicted olfactory responses in juvenile Pacific salmon

(2010) David K. DeForest et al.   Integrated Environmental Assessment and Management

Trophic transfer of Cd from natural periphyton to the grazing mayfly Centroptilum triangulifer in a life cycle test

(2009) Lingtian Xie et al.   ENVIRONMENTAL POLLUTION

Uptake of Hydrophobic Metal Complexes by Three Freshwater Algae: Unexpected Influence of pH

(2009) Amiel Boullemant et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

AN ENRICHED STABLE-ISOTOPE APPROACH TO DETERMINE THE GILL–ZINC BINDING PROPERTIES OF JUVENILE RAINBOW TROUT (ONCORHYNCHUS MYKISS) DURING ACUTE ZINC EXPOSURES IN HARD AND SOFT WATERS

(2009) Andrew S. Todd et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Kinetic and equilibrium studies of copper-dissolved organic matter complexation in water column of the stratified Krka River estuary (Croatia)

(2009) Yoann Louis et al.   MARINE CHEMISTRY

Environmental risk assessment of zinc in European freshwaters: A critical appraisal

(2009) P.A. Van Sprang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Effects of Mg2+ and H+ on the toxicity of Ni2+ to the unicellular green alga Pseudokirchneriella subcapitata: Model development and validation with surface waters

(2009) Nele M.E. Deleebeeck et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Incubating Rainbow Trout in Soft Water Increased Their Later Sensitivity to Cadmium and Zinc

(2009) Christopher A. Mebane et al.   WATER AIR AND SOIL POLLUTION

Modes of metal toxicity and impaired branchial ionoregulation in rainbow trout exposed to mixtures of Pb and Cd in soft water

(2008) O BIRCEANU et al.   AQUATIC TOXICOLOGY

Development of a biotic ligand model for the acute toxicity of zinc to Daphnia pulex in soft waters

(2008) Matthew Clifford et al.   AQUATIC TOXICOLOGY

Effects of water chemistry variables on gill binding and acute toxicity of cadmium in rainbow trout (Oncorhynchus mykiss): A biotic ligand model (BLM) approach

(2008) Som Niyogi et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

THE ECOLOGICAL NICHE OFDAPHNIA MAGNACHARACTERIZED USING POPULATION GROWTH RATE

(2008) Helen L. Hooper et al.   ECOLOGY

Do you smell what I smell? Olfactory impairment in wild yellow perch from metal-contaminated waters

(2008) R.S. Mirza et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

A Matter of Potential Concern: Natural Organic Matter Alters the Electrical Properties of Fish Gills

(2008) Fernando Galvez et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Chemosensory Deprivation in Juvenile Coho Salmon Exposed to Dissolved Copper under Varying Water Chemistry Conditions

(2008) Jenifer K. McIntyre et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

A NOVEL METHOD FOR PREDICTING CHRONIC NICKEL BIOAVAILABILITY AND TOXICITY TO DAPHNIA MAGNA IN ARTIFICIAL AND NATURAL WATERS

(2008) Nele M.E. Deleebeeck et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

EFFECTS OF DIETBORNE COPPER AND SILVER ON REPRODUCTION BY CERIODAPHNIA DUBIA

(2008) Jason M. Kolts et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Influence of flow-through and renewal exposures on the toxicity of copper to rainbow trout

(2007) Paul G. Welsh et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Toxicity of urban highway runoff with respect to storm duration

(2007) M. Kayhanian et al.   SCIENCE OF THE TOTAL ENVIRONMENT