Impact of chlorpyrifos on blood glucose concentration in an animal model: a systematic review and meta-analysis

Chlorpyrifos, an organophosphate insecticide, disturbs blood glucose hemostasis in experimental models and causes metabolic disorders. However, there are controversial findings of its impact on the BS level. The present meta-analysis aimed to investigate blood gluocse levels in rats exposed to chlorpyrifos. Present systematic review and meta-analysis study was done by searching in the online databases, including Google Scholar, Web of Science, PubMed, and Scopus. Data were analyzed by performing random effects meta-regression. Findings were expressed as standardized mean value and 95% confidence interval (CI). Heterogeneity between studies was assessed using I-square and Q test. Meta-analysis of 7 animal studies indicated the dose-dependence manner of chlorpyrifos exposure on the blood glucose levels. The subgroup analysis indicated that exposure to low doses of chlorpyrifos significantly increased the blood glucose levels in exposed animals versus the nonexposed (0.11; 95% CI: - 1.14, 1.36, z = 2.25, p = 0.03, I-2 = 90.1%, p < 0.001) and high doses markedly decreased blood glucose levels in exposed rats versus the nonexposed (7.34; 95%CI: - 9.35, - 5.32, z = 6.41, p < 0.001, I-2 = 96.9%, p < 0.001). The random effects and pooled analysis indicated that the blood glucose levels were 4.22-fold lower in exposed animals versus the nonexposed ones (95% CI: 5.59,- 2.85; Z = 3.97; p < 0.001); therefore, heterogeneity was significant (I-2 = 96.5%, p < 0.001). The present finding indicated the association between chlorpyrifos exposure and a decrease in blood glucose levels. However, more studies should be designed to clarify this effect of chlorpyrifos exposure on blood glucose levels and involved mechanisms.