Article
Environmental Sciences
Ze-Min Zhao, Su Mei, Qi-Yue Zheng, Jiao Wang, Yi-Ru Yin, Jiao-Jiao Zhang, Xian-Zhong Wang
Summary: This study shows that lead acetate exposure can impair reproductive function in male mice, including reducing sperm quality and inducing inflammatory damage. Oxidative stress and inflammatory response are key mechanisms underlying these adverse effects of lead acetate. Melatonin and vitamin C can serve as effective measures to counteract the toxic effects of lead acetate.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Emrah Zayman, Mehmet Gul, Mehmet Erman Erdemli, Semir Gul, Harika Gozukara Bag, Elif Taslidere
Summary: This study investigated the protective effects of melatonin and vitamin E against the negative effects of acetamiprid on testicles, reproductive hormones, and oxidative stress parameters. The results showed that acetamiprid caused testicular tissue damage, oxidative stress, and decreased reproductive hormone levels, while melatonin and vitamin E could reduce these damages.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Medicine, Research & Experimental
Virna M. Martin Gimenez, Ivana Bergam, Russel J. Reiter, Walter Manucha
Summary: Metal ion homeostasis is crucial for maintaining the balance of cellular antioxidative status, with zinc and copper playing central roles in regulating multiple functions associated with the body's antioxidative defense network.
Article
Environmental Sciences
Wang Guo, Ya Yang, Xia Zhou, Renyue Ming, Deyu Hu, Ping Lu
Summary: Acetamiprid has harmful effects on Rana nigromaculata tadpoles, with acute toxicity and rapid accumulation. The study also reveals oxidative stress and significant changes in metabolites.
Article
Biochemistry & Molecular Biology
Francesco Violi, Cristina Nocella, Lorenzo Loffredo, Roberto Carnevale, Pasquale Pignatelli
Summary: Vitamin E possesses antioxidant and anti-inflammatory properties that have an impact on atherosclerosis and thrombus formation, but intervention trials have yielded negative results.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Chemistry, Multidisciplinary
Annu Phogat, Jagjeet Singh, Vijay Kumar, Vinay Malik
Summary: Acetamiprid, a widely used alternative to organophosphates and carbamates, has adverse effects on non-targeted organisms and is detected in various environmental sources. Metabolism of acetamiprid generates toxic metabolites that affect neurological, hepatorenal, immunological, genotoxic, and reproductive systems. Therapeutic use of plant extracts and antioxidants can alleviate acetamiprid-induced oxidative stress.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Article
Environmental Sciences
Gokhan Nur, H. Ahmet Deveci, Evren Koc
Summary: The study confirmed the protective effect of vitamin E against dichlorvos toxicity, which can help reduce renal tissue damage in rats. Additionally, the toxic inflammation caused by dichlorvos can be alleviated through vitamin E supplementation.
FRESENIUS ENVIRONMENTAL BULLETIN
(2021)
Review
Medicine, Research & Experimental
Aman B. Upaganlawar, Nitu L. Wankhede, Mayur B. Kale, Mohit D. Umare, Aayush Sehgal, Sukhbir Singh, Saurabh Bhatia, Ahmed Al-Harrasi, Agnieszka Najda, Renata Nurzynska-Wierdak, Simona Bungau, Tapan Behl
Summary: Epilepsy, affecting nearly 50 million people worldwide, can be caused by genetic predisposition or acquired acute insult leading to alteration of cellular and molecular mechanisms. The imbalanced state of enhanced excitatory glutamatergic and reduced inhibitory GABAergic signaling is considered to be accountable for seizures associated damage. Neurodegeneration contributing to epileptogenesis has become increasingly appreciated, with potential intervention through vitamin E therapy in managing epilepsy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Zhengting Lu, Wentao Ye, Piao Feng, Minli Dai, Dandan Bian, Yuying Ren, Qingyu Zhu, Tingting Mao, Wujie Su, Fanchi Li, Haina Sun, Jing Wei, Bing Li
Summary: The study indicates that exposure to low concentration of acetamiprid causes oxidative stress in silkworm posterior silk glands, which may be the reason for cocooning disorder. Our findings provide a reference for evaluating the safety of acetamiprid environmental residues on non-target insects.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Virginia Boccardi, Giulia Poli, Roberta Cecchetti, Patrizia Bastiani, Michela Scamosci, Marta Febo, Emanuela Mazzon, Stefano Bruscoli, Stefano Brancorsini, Patrizia Mecocci
Summary: Alzheimer's disease (AD) is the leading cause of dementia globally and is a major contributor to disability in older individuals. Vitamin E levels are lower in AD patients, and inflammation and microRNAs also play significant roles in the development of AD. MiR-122 may be a modulating factor, correlating with alpha-tocopherol and inflammation molecules.
Article
Biochemistry & Molecular Biology
Jing Zhang, Yuecheng Sun, Wentao Song, Anshan Shan
Summary: This study found that exposure to phoxim at low levels can cause bioaccumulation with neurotoxicity, oxidative stress, tissue damage, and abnormal nutrient metabolism. Vitamin E was found to alleviate phoxim-induced nephrotoxicity by inhibiting mitochondrial apoptosis.
Article
Environmental Sciences
Hui Jiao, Tingting Yuan, Xiaohuan Wang, Xia Zhou, Renyue Ming, Honghao Cui, Deyu Hu, Ping Lu
Summary: This study assessed the toxic effects of acetamiprid on Xenopus laevis and found that it had detrimental effects on the liver, causing oxidative stress and histological damage. Metabolomic analysis revealed disrupted metabolic pathways, indicating the hepatotoxic effects of acetamiprid on X. laevis at a molecular level. These findings are crucial for evaluating the aquatic risks of neonicotinoids.
ENVIRONMENTAL POLLUTION
(2023)
Article
Engineering, Chemical
Penny Vlahos, Stephen L. Schensul, Shuchi Anand, Emma Shipley, Saranga Diyabalanage, Chaoran Hu, Toan Ha, Allison Staniec, Lalarukh Haider, Jean J. Schensul, Pasan Hewavitharane, Tudor Silva, Rohana Chandrajith, Nishantha Nanayakkara
Summary: This study reveals that exposure to well water in Wilgamuwa, Sri Lanka is associated with kidney function decline, and identifies a cluster with significantly higher CKDu progression than surrounding areas through geospatial analysis. Analysis of household well samples shows that 68% exceed global water quality standards.
Article
Chemistry, Multidisciplinary
Xinhao Yan, Wenjie Lin, Huan Liu, Wendan Pu, Junhong Li, Peng Wu, Jun Ding, Gaoxing Luo, Jianxiang Zhang
Summary: The OVE-based nanoprobes can effectively detect inflammation and oxidative stress, offering a highly sensitive imaging method. By combining with different fluorophores, OVE can generate luminescence systems with emission wavelengths ranging from blue to near-infrared light, providing guidance for the progression of various diseases.
Article
Biochemistry & Molecular Biology
Martin Alcala, Victoria E. Bolado, Isabel Sanchez-Vera, Sonia Clapes, Francisco Dasi, Guillermo Saez, Esther Carrera, Fabiola Alvarez-Gallego, Mary R. Loeken, Marta Viana
Summary: Studies on rats and cell cultures have shown that obesity depletes maternal glutathione, reducing the antioxidant capacity in embryos, which can lead to malformations. Vitamin E supplementation can prevent this process and protect against birth defects.
Article
Biotechnology & Applied Microbiology
Zeynep Ozdemir, Arzu Karakurt, Elif Taslidere, Nigar Vardi, Mehmet Abdullah Alagoz, Hakan Parlakpinar, Harun Uslu, Harika Gozukara Bag
Summary: Depression is a serious psychological disorder that affects a significant population. The study found that four pyridazinone derivatives containing the hydrazide moiety exhibited good antidepressant activity, with compound 2 showing the most promising results. Toxic effects of the compounds on liver and stomach tissue were also evaluated.
BIOTECHNIC & HISTOCHEMISTRY
(2022)
Article
Environmental Sciences
Emrah Zayman, Mehmet Gul, Mehmet Erman Erdemli, Semir Gul, Harika Gozukara Bag, Elif Taslidere
Summary: This study investigated the protective effects of melatonin and vitamin E against the negative effects of acetamiprid on testicles, reproductive hormones, and oxidative stress parameters. The results showed that acetamiprid caused testicular tissue damage, oxidative stress, and decreased reproductive hormone levels, while melatonin and vitamin E could reduce these damages.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pediatrics
Mehmet Oncul, Cemsit Karakurt, Ozlem Elkiran, Harika Gozde Gozukara
Summary: This retrospective study evaluated the clinical course and treatment of patients with congenital heart disease and COVID-19. The results showed that these patients had severe illness and high mortality rate. Therefore, close and careful follow-up is required for patients with congenital heart disease and COVID-19.
IRANIAN JOURNAL OF PEDIATRICS
(2022)
Article
Oncology
Gonca Gulbay, Harika Gozukara Bar, Elif Yesilada, Mehmet Ali Erkurt
Summary: This study investigates the role of CALR gene mutations in Philadelphia Chromosome Negative Myeloproliferative Neoplasms (MPNs), revealing that CALR mutations are a significant molecular marker in these types of tumors, requiring further investigation.
UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI
(2022)
Article
Gastroenterology & Hepatology
Semra Gurunluoglu, Mehmet Gul, Kubilay Gurunluoglu, Alper Kocbiyik, Semir Gul, Harika Gozukara Bag, Muhammed Mehdi Uremis, Mehmet Demircan
Summary: This study examines the effects of parenteral nutrition (PN) combined with starvation on rabbit small intestines. The results indicate that PN combined with starvation can lead to apoptosis and tissue damage in the small intestine, while enteral nutrition may reduce these effects.
ARAB JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Zeynep Kucukakcali, Cemil Colak, Harika Gozde Gozukara Bag, Ipek Balikci Cicek, Onural Ozhan, Azibe Yildiz, Nefsun Danis, Ahmet Koc, Hakan Parlakpinar, Sami Akbulut
Summary: This study aimed to perform bioinformatic analysis of lncRNAs from liver tissue samples of rats with cisplatin hepatotoxicity and without pathology. It also aimed to identify possible biomarkers for hepatotoxicity diagnosis through ensemble learning methods. The results showed that certain lncRNAs can be used as predictive biomarker candidates for hepatotoxicity.
Article
Medicine, General & Internal
Harika Gozde Gozukara Bag, Fatma Hilal Yagin, Yasin Gormez, Pablo Prieto Gonzalez, Cemil Colak, Mehmet Gulu, Georgian Badicu, Luca Paolo Ardigo
Summary: This study used machine learning techniques to classify obesity levels based on physical activity and nutritional habits. The results showed that the logistic regression model performed the best, and feature selection improved model efficiency. The study emphasizes the importance of considering both physical activity and nutritional habits in addressing obesity.
Article
Biochemistry & Molecular Biology
Ezgi Karaaslan, Sukru Kartalci, Harika Gozde Gozukara Bag, Ceren Acar
Summary: This study investigated the DNA methylation differences in the MMP9 gene between schizophrenia patients and healthy individuals. The results showed significant differences in CpG 7-3, CpG 7-4, and CpG 7-5 positions as well as the overall methylation patterns in the 7th exon of MMP9 between these two groups. The study provided evidence for the potential DNA methylation differences in schizophrenia and emphasized the importance of the epigenetic aspect of the disorder.
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
(2023)
Article
Medicine, General & Internal
Fatih Ozdemir, Volkan Ince, Sertac Usta, Brian I. I. Carr, Harika G. G. Bag, Ayse Nur Akatli, Aysegul Sagir Kahraman, Sezai Yilmaz
Summary: This study reviewed and compared the prognostic impact and clinicopathologic features of incidental hepatocellular carcinoma (iHCC) patients and hepatocellular carcinoma diagnosed before liver transplantation (pdHCC) patients. The results showed that iHCC patients had better histopathologic features and survival rates with lower tumor recurrence compared to pdHCC patients.
MEDICINA-LITHUANIA
(2023)
Article
Gastroenterology & Hepatology
Mehmet Mustafa Erdogan, Mehmet Erman Erdemli, Onural Ozhan, Zeynep Erdemli, Harika Gozde Gozukara Bag, Nigar Vardi
Summary: This study investigated the effects of intraperitoneal melatonin administration on liver preservation damage before transplantation. The results showed that melatonin can reduce cell death and improve the immunohistochemical and biochemical properties of liver tissue.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, Research & Experimental
Nursena Demircigil, Mehmet Gul, Nurcan Gokturk, Elif Kayhan Kustepe, Harika Gozukara Bag, Mehmet Erman
Summary: This study aimed to observe the toxic effects of Tartrazine on the liver and investigate whether thymoquinone coadministration could eliminate this toxicity. The results showed that Tartrazine administration caused oxidative stress and inflammation in the liver tissue, while thymoquinone had antioxidant and anti-inflammatory effects.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Volkan Ince, Brian Carr, Sertac Usta, Veysel Ersan, Harika Gozukara Bag, Sezai Yilmaz
Summary: This study examined the impact of pre-transplant plasma lipid profiles on post-transplant tumor recurrence in patients with hepatocellular carcinoma. The results showed that low high-density lipoprotein cholesterol levels were significantly associated with portal vein thrombosis and poor post-transplant overall and disease-free survivals.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Ethics
Mehmet Karatas, Sukru Kartalci, Engin Burak Selcuk, Hakan Yetis, Turgay Karatas, Harika Gozukara
Summary: Evaluation of the physician-patient relationship is crucial for determining priorities in medical practice. In this study, the communication between psychiatrists and psychotic patients was assessed, and it was found that increased consultation duration positively correlated with higher evaluation scores. This work is significant as it focuses on the sensitive area of psychiatric patients, and the results indicate that the communication between psychiatrists and psychotic patients was sensitive, careful, and without ethical issues.
Article
Medicine, General & Internal
Harika Gozde Gozukara Bag, Mehmet Kivrak, Emek Guldogan, Cemil Colak
Summary: This study aimed to design an intelligent model to predict the severity level of COVID-19 by modeling the relationships between infection severity and demographic/clinical features. Results showed that the proposed voting ensemble model outperformed other individual and ensemble machine learning approaches. The model can be integrated into web or mobile applications for clinical decision support.
ACTA MEDICA MEDITERRANEA
(2022)
Article
Medicine, Research & Experimental
Yucel Duman, Yasemin Ersoy, Elif Seren Tanriverdi, Bans Otlu, Sibel Altunisik Toplu, GOzde Goziikara, Mehmet Sait Tekerekoglu, Nazire Bulam, Elif Kaplan Canturk, Nalan Parmaksiz
Summary: This study aimed to evaluate the oral colonization of Acinetobacter baumannii in ICU patients and investigate the associated risk factors, molecular epidemiology, and incidence of pneumonia and sepsis. The results showed that A. baumannii was detected in the oral cultures of 21 out of 96 patients. Pneumonia and sepsis caused by A. baumannii were found in 14 and 5 patients, respectively. The presence of plasmid-mediated mcr-2 colistin resistance gene in a colistin susceptible A. baumannii strain was also identified. The findings highlight the significance of oral colonization of A. baumannii in ICUs and emphasize the need for infection control measures to prevent the colonization of resistant isolates.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
