Article
Medicine, Research & Experimental
David J. Cvancara, Julio A. de Leon, Hans C. Baertsch, Zaroug Jaleel, Greg Kinney, Vicente Martinez, Neel K. Bhatt
Summary: Superior laryngeal nerve evoked responses were successfully recorded in a rat model, demonstrating feasibility and potential for future studies. Consistent data across multiple trials and animals could provide valuable normative data for translational research.
Article
Surgery
Shiying Zeng, Qinglai Tang, Qian Yang, Xinming Yang, Zian Xiao, Ying Zhang, Peiying Huang, Shisheng Li
Summary: Preserving the internal branch of superior laryngeal nerve in transoral surgery can help achieve satisfactory recovery of swallowing function after surgery for hypopharyngeal squamous cell carcinoma.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Neurosciences
Kazutaka Ohi, Kentaro Takai, Ayumi Kuramitsu, Shunsuke Sugiyama, Toshiki Shioiri
Summary: This study identified common cortical alterations between smoking behavior and bipolar disorder (BD), suggesting the common neurobiological involvement of insular thickness in smoking behavior and BD risk.
Article
Medicine, Research & Experimental
Michael S. Benninger, Brooke A. Quinton, William S. Tierney, Victoria L. Gau, Rebecca C. Nelson, Candace M. Hrelec, Paul C. Bryson
Summary: This study investigated the effect of superior laryngeal nerve (SLN) block in patients with non-cough complaints relating to the larynx. The results showed that most patients experienced some degree of improvement in their symptoms, especially those with spasmodic dysphonia, odynophagia, and hyoid bone syndrome. However, patients with globus sensation had a lower response to this therapy. Further research is needed to confirm the efficacy of this treatment.
Article
Otorhinolaryngology
Kai-ning Lu, Jin-wang Ding, Yu Zhang, Jing-jing Shi, Li Zhou, You Peng, Jie Shen, Si Lu, Si-han Sun, Ye-qin Ni, Huai-rui Cui, Ding-cun Luo
Summary: The study identifies unique anatomical features of the superior laryngeal nerve in Chinese individuals, providing a new method for rapid localization during operations that can reduce the risk of damage.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Medicine, General & Internal
Antonio S. Dekhou, Robert J. Morrison, Jickssa M. Gemechu
Summary: The anatomical considerations of the superior laryngeal nerve are important for minimizing intraoperative injury and preventing laryngeal dysfunctions. This study aimed to assess SLN variations and its relationships with the superior thyroid artery and superior laryngeal artery. The study found variations in the relationships between ebSLN/STA and ibSLN/SLA, highlighting the importance of awareness for identifying and isolating these structures to prevent nerve injury.
Article
Medicine, Research & Experimental
Courtney B. Tipton, Rameen Walters, Rachana Gudipudi, Drasti Smyre, Shaun Nguyen, Ashli K. O'Rourke
Summary: This study evaluated the efficacy and safety of superior laryngeal nerve block for neurogenic cough through a placebo-controlled trial. 80% of patients in the treatment group reported improvement with at least one injection, while only 14.3% of patients in the placebo group reported improvement. The average total scores of the Leicester Cough Questionnaire increased significantly in the treatment group. Evaluation: 7 points.
Article
Surgery
Yishen Zhao, Zihan Zhao, Tie Wang, Daqi Zhang, Gianlorenzo Dionigi, Hui Sun
Summary: The study demonstrated the effectiveness of using the area under the waveform (AUW) to monitor the external branches of the superior laryngeal nerve (EBSLN) during thyroidectomy, showing higher sensitivity in predicting nerve injuries compared to traditional amplitude monitoring.
Article
Medicine, Research & Experimental
Kathleen M. Tibbetts, Gregory R. Dion, Laura M. Dominguez, Michael J. Loochtan, C. Blake Simpson
Summary: A retrospective review of patients undergoing in-office superior laryngeal nerve block for paralaryngeal pain between 2015 and 2018 at two tertiary care centers showed that 82% reported improvement in symptoms. Additionally, 39% of patients with odynophonia related to vocal effort had improvement or resolution of their symptoms.
Article
Neurosciences
Akiyo Fujita, Chiho Kato, Yasunori Abe, Hideyuki Ishidori, Ruixin Li, Phyo Thura Aung, Takuya Ogawa, Hidemasa Okihara, Satoshi Kokai, Takashi Ono
Summary: This study found that chronic unilateral nasal obstruction affects the functional development of the cortical masticatory area (CMA) in growing rats, potentially impacting respiratory and orofacial functions.
NEUROSCIENCE LETTERS
(2022)
Article
Medicine, Research & Experimental
Nicholas Talbot, Margaret Heller, Sarah Nyirjesy, Brandon Kim, Brad DeSilva, Laura Matrka
Summary: A study explored the treatment options for neurogenic cough related to hypersensitivity of the internal branch of the superior laryngeal nerve (SLN) and found that SLN block had positive effects on symptomatic improvements. Repeat injections may further improve symptoms. The study also found that there were no specific predictors of response, suggesting that a broader range of patients may benefit from this intervention.
Article
Endocrinology & Metabolism
Changlin Li, Jiao Zhang, Gianlorenzo Dionigi, Hui Sun
Summary: This study used intraoperative neuromonitoring (IONM) to assess the value of different classifications of the external branch of the superior laryngeal nerve (EBSLN) in predicting the risk of EBSLN injury. The Friedman classification showed higher accuracy, sensitivity, and specificity compared to the Cernea and Kierner classifications in predicting EBSLN injury. Friedman 2 was defined as a high-risk subtype of EBSLN.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Brooke A. Quinton, William S. Tierney, Michael S. Benninger, Rebecca C. Nelson, Victoria L. Gau, Candace M. Hrelec, Paul C. Bryson
Summary: The study found that bilateral SLN block is an effective treatment for refractory chronic cough, with an average reduction in symptoms of 67.3% and lasting benefit for an average of 7.60 weeks.
Article
Medicine, Research & Experimental
Ayaka J. Iwata, Whitney Liddy, Marcin Barczynski, Che-Wei Wu, Tzu-Yen Huang, Sam Van Slycke, Rick Schneider, Gianlorenzo Dionigi, Henning Dralle, Claudio R. Cernea, Dipti Kamani, Amr H. Ahmed, Okenwa C. Okose, Bo Wang, Gregory W. Randolph
Summary: This study found that EBSLN injuries during thyroidectomy can be evaluated and optimized using CTM needle electrodes, with complete signal loss associated with specific factors. Observations suggest that CTM needle electrodes have the ability to measure finer amplitude changes and may help to improve voice outcomes.
Article
Clinical Neurology
Hans Baertsch, David J. Cvancara, Randal C. Paniello, Allen D. Hillel, Neel K. Bhatt
Summary: This study aimed to explore the feasibility of performing recurrent laryngeal motor nerve conduction studies (rlMNCS) in a rat model. The results showed that rlMNCS are feasible in understanding laryngeal neurophysiology and could provide a potential animal model for studying neuromuscular conditions affecting voice, breathing, and swallowing.
Article
Otorhinolaryngology
Taku Suzuki, Takanori Tsujimura, Jin Magara, Naohito Hao, Naru Shiraishi, Kazuya Maekawa, Kazuo Matsushima, Makoto Inoue
Summary: Oral status, swallowing function, oral intake level, and consciousness level are key factors affecting the survival of older patients with aspiration pneumonia. Patients in the deceased group showed significantly worse outcomes in terms of oral status, swallowing function, and consciousness level.
Article
Otorhinolaryngology
Taku Suzuki, Sirima Kulvanich, Takanori Tsujimura, Jin Magara, Yasushi Ohnishi, Makoto Inoue
Article
Neurosciences
Sirima Kulvanich, Haruka Sakai, Riho Takanami, Mako Yamada, Anna Sasa, Kayoko Ito, Takanori Tsujimura, Jin Magara, Makoto Inoue
Summary: This study aimed to identify oral status-related factors that could predict oral intake recovery in acute stroke patients. The findings showed that posterior tongue pressure could significantly predict complete oral intake recovery, and tongue pressure and modified water swallowing test score also influenced diet forms. Improvement of other oral status-related factors, such as oral moisture and dentition status, indicated improvement of diet forms and swallowing function.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2022)
Article
Otorhinolaryngology
Takanori Tsujimura, Yuta Nakajima, Titi Chotirungsan, Satomi Kawada, Yuhei Tsutsui, Midori Yoshihara, Taku Suzuki, Kouta Nagoya, Jin Magara, Makoto Inoue
Summary: This study found that noxious mechanical stimulation of the tongue inhibits the initiation of swallowing and modulates neuronal activity in the nucleus tractus solitarii.
Article
Dentistry, Oral Surgery & Medicine
Wakana Onuki, Jin Magara, Kayoko Ito, Reiko Ita, Satomi Kawada, Yuhei Tsutsui, Yuta Nakajima, Haruka Sakai, Takanori Tsujimura, Makoto Inoue
Summary: This study aimed to evaluate the impact of management for patients with oral hypofunction on their oral health. The results showed that oral function significantly improved after receiving management, and an increase in occlusal force was crucial for recovering from oral hypofunction.
Article
Dentistry, Oral Surgery & Medicine
Anna Sasa, Sirima Kulvanich, Naohito Hao, Reiko Ita, Masahiro Watanabe, Taku Suzuki, Jin Magara, Takanori Tsujimura, Makoto Inoue
Summary: This study investigated the difference in suprahyoid muscle activity between freely and unilaterally chewing tasks, as well as between the working and non-working sides during chewing. The results demonstrated that unilaterally chewing had a longer duration and a higher chewing rate. The duration of chewing significantly differed based on the hardness of the food. Moreover, the activities of the suprahyoid muscles were higher during soft rice cracker chewing. The masseter muscle activity was higher on the chewing side, while there was no difference in suprahyoid muscle activity between the sides.
JOURNAL OF ORAL REHABILITATION
(2022)
Article
Multidisciplinary Sciences
Kayoko Ito, Naoko Izumi, Saori Funayama, Kaname Nohno, Kouji Katsura, Noboru Kaneko, Makoto Inoue
Summary: The study analyzed the status of patients with medication-induced xerostomia and investigated factors associated with its improvement. Treatment improved oral dryness in 75.3% of patients, contributing to the quality of life and potentially reducing medication discontinuation.
Article
Gastroenterology & Hepatology
Yuta Nakajima, Takanori Tsujimura, Yuhei Tsutsui, Titi Chotirungsan, Satomi Kawada, Nozomi Dewa, Jin Magara, Makoto Inoue
Summary: Anticholinergic medication can cause swallowing difficulties and dry mouth, but the mechanisms by which these drugs affect the swallowing reflex are not yet clear. This study investigated the effects of the muscarinic acetylcholine receptor (mAChR) antagonist atropine on swallowing initiation. The results suggest that atropine facilitates swallowing triggered by distilled water through central mAChR actions.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Otorhinolaryngology
Taku Suzuki, Haruka Hino, Jin Magara, Takanori Tsujimura, Kayoko Ito, Makoto Inoue
Summary: This study investigated the effects of head and neck alignment and pharyngeal anatomy on epiglottic inversion in patients with dysphagia. Data from 113 patients who underwent videofluoroscopic swallowing study were analyzed. The results showed that poor head and neck alignment or posture, as well as a narrow pharyngeal cavity, constrained epiglottic inversion in dysphagia patients.
Article
Dentistry, Oral Surgery & Medicine
Titi Chotirungsan, Yuhei Tsutsui, Nobuaki Saka, Satomi Kawada, Nozomi Dewa, Taku Suzuki, Jin Magara, Takanori Tsujimura, Makoto Inoue
Summary: This study examined the modulation of reflex responses in the anterior and posterior bellies of the digastric muscle in conscious rats. The results showed that chewing, licking, and swallowing significantly reduced the amplitude of the reflex responses and delayed their onset. This suggests that central pattern generators are activated during feeding behaviors to maintain coordination of jaw and hyoid movements.
JOURNAL OF ORAL REHABILITATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Reiko Ita, Jin Magara, Yuto Ochiai, Takanori Tsujimura, Makoto Inoue
Summary: The study aimed to measure the electromyograms (EMGs) of the intrinsic tongue (I-ton) muscles using suction electrodes, and evaluate the integrated EMG amplitude (iEMG) and mean power frequency (MPF) of EMG in the I-ton and hyoid muscles during continuous lingual pressure (LP) generation. The results showed that the I-ton muscles easily fatigue during 10-second LP generation tasks, while the suprahyoid (S-hyo) and infrahyoid (I-hyo) muscles may help compensate for the weakened I-ton muscle activity by increasing their activity to maintain LP.
JOURNAL OF ORAL REHABILITATION
(2023)
