Journal
BRAIN RESEARCH
Volume 1630, Issue -, Pages 38-49Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2015.10.045
Keywords
Vasomotor control; Laser-Doppler perfusion imaging; Skin perfusion; Nerve injury; Median nerve; Ulnar nerve
Categories
Funding
- National Natural Science Foundation of China [81100939, 81130080]
- National High-Tech Research and Development Program of China (863 Program) [2012AA020502]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- Jiangsu Collegiate Qing Lan Project
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Cutaneous vasoconstriction/vasodilatation occurs in response to whole body and local cooling/heating, and the vasomotor activities play a pivotal role in thermal control of the human body. The mechanisms underlying regulation of skin blood flow involve both neurogenic and humeral/local chemical influence, contributing to the initial response to thermal stimuli and the prolonged phase of response, respectively. Previous studies have suggested the impairment of cutaneous thermal regulation after nerve injury. However, the evidence regarding how the skin perfusion and thermoregulatoiy response evolve after nerve injury and repair remains limited. Here we observed, by utilizing laser-Doppler perfusion imaging, baseline skin perfusion and perfusion change in response to thermal stimuli after median and ulnar nerve injury, and the results showed that baseline perfusion in autonomous skin area profoundly decreased and active rewarming after clod stress dramatically diminished before sensory recovery of the skin became detectable. In addition, baseline cutaneous perfusion was recovered as the skin regained touch sensation, and exhibited positive correlation to touch sensibility of the skin. These data indicate that both active perfusion and thermoregulatory response of the skin are markedly compromised during skin denervation and can be recovered by re-innervation. This suggests the importance of timely repair of injured nerve, especially in the practice of replantation. (C) 2015 Elsevier B.V. All rights reserved.
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