Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 186, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2019.109755
Keywords
Heavy metals; Prenatal exposure; Sex difference; Placental transfer efficiency; Placental accumulation; Silver
Categories
Funding
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB14010300]
- National Natural Science Foundation of China [21677170, 21876194, 21577167]
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It has been demonstrated that heavy metals cross the placental barrier and exert potentially harmful fetal effects. Although previous studies showed sex differences in response to similar intrauterine environments, little is known about fetal sex-related differences in placental transfer and accumulation of heavy metals. This study aimed to reveal the sex-specific risk of fetal exposure to heavy metals in pregnant women. We detected the exposure levels of eight heavy metals in 64 paired mother-infant maternal blood, cord blood and placental tissue samples. We found that the placental transfer efficiency (PTE) of titanium (Ti) and silver (Ag) was significantly higher in the group with male fetuses than that with female fetuses. The group with male fetuses had a larger placental:maternal blood ratio of Ag levels than the group with female fetuses, indicating fetal sex-related differences in placental transfer and accumulation of Ag. Prospective research should focus on the sex differences of adverse health effects induced by heavy metals and other pollutants.
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