Journal
BRAIN RESEARCH
Volume 1639, Issue -, Pages 214-227Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2015.07.029
Keywords
Parkinson's disease; Mitochondrial permeability; transition pore; Treatment
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Funding
- National Basic Research Program of China [2011CB504102, 2012CB722407]
- National Natural Science Foundation of China [81371398]
- Natural Science Foundation of Beijing Municipality [7131001]
- Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges under Beijing Municipality [IDHT20140514]
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Currently available treatment approaches for Parkinson's disease (PD) are limited in terms of variety and efficacy. Piper longum L. (PLL; Piperaceae) is used in traditional medicine in Asia and the Pacific Islands, with demonstrated anti-inflammatory and antioxidant activities in preclinical studies, and alkaloid extracts of PLL have shown protective effects in PD models. The present study investigated the mechanistic basis for the observed protective effects of PLL. Rats treated with PLL-derived alkaloids showed improvement in rotenone-induced motor deficits, while reactive oxygen species (ROS) production was decreased, mitochondrial membrane potential was stabilized, and the opening of the mitochondrial permeability transition pore (mPTP) which is involved in ROS production was inhibited. In addition, rotenone-induced apoptosis was abrogated in the presence of these alkaloids, while a pretreatment stimulated autophagy, likely mitigating neuronal injury by the removal of damaged mitochondria. These findings provide novel insight into the neuroprotective function of PLL as well as evidence in favor of its use in PD treatment. This article is part of a Special Issue entitled SI: Neuroprotection. (C) 2015 Published by Elsevier B.V.
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