Journal
BRAIN RESEARCH
Volume 1645, Issue -, Pages 58-60Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.brainres.2016.02.001
Keywords
Pain; Spinal cord; N-methyl-d-aspartate (NMDA) receptors; Central sensitisation
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Funding
- Wellcome Trust Pain Consortium
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We used in vivo electrophysiology and a model of more persistent nociceptive inputs to monitor spinal cord neuronal activity in anaesthetised rats to reveal the pharmacology of enhanced pain signalling. The study showed that all responses were blocked by non-selective antagonism of glutamate receptors but a selective and preferential role of the N-methyl-D-aspartate (NMDA) receptor in the prolonged plastic responses was clearly seen. The work lead to many publications, initially preclinical but increasingly from patient studies, showing the importance of the NMDA receptor in central sensitisation within the spinal cord and how this could relate to persistent pain states. This article is part of a Special Issue entitled SI:50th Anniversary Issue. (C) 2016 Elsevier B.V. All rights reserved.
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