Dual glucagon‐like peptide‐1 receptor/glucagon receptor agonist SAR425899 improves beta‐cell function in type 2 diabetes

MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study

(2018) Philip Ambery et al.   LANCET

A novel dual glucagon-like peptide and glucagon receptor agonist SAR425899: Results of randomized, placebo-controlled first-in-human and first-in-patient trials

(2018) Joachim Tillner et al.   DIABETES OBESITY & METABOLISM

Unimolecular Polypharmacy for Treatment of Diabetes and Obesity

(2016) Matthias H. Tschöp et al.   Cell Metabolism

Glucagon increases energy expenditure independently of brown adipose tissue activation in humans

(2015) V. Salem et al.   DIABETES OBESITY & METABOLISM

Emerging opportunities for the treatment of metabolic diseases: Glucagon-like peptide-1 based multi-agonists

(2015) Brian Finan et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

GLP-1 based therapeutics: simultaneously combating T2DM and obesity

(2015) Kristy M. Heppner et al.   Frontiers in Neuroscience

The Oral Minimal Model Method

(2014) C. Cobelli et al.   DIABETES

Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin

(2013) C. Kapitza et al.   DIABETES OBESITY & METABOLISM

The Effect of a Bile Acid Sequestrant on Glucose Metabolism in Subjects With Type 2 Diabetes

(2012) G. Smushkin et al.   DIABETES

Coadministration of Glucagon-Like Peptide-1 During Glucagon Infusion in Humans Results in Increased Energy Expenditure and Amelioration of Hyperglycemia

(2012) T. M. Tan et al.   DIABETES

A concerted decline in insulin secretion and action occurs across the spectrum of fasting and postchallenge glucose concentrations

(2011) Airani Sathananthan et al.   CLINICAL ENDOCRINOLOGY

A model of GLP-1 action on insulin secretion in nondiabetic subjects

(2010) Chiara Dalla Man et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The metabolic actions of glucagon revisited

(2010) Kirk M. Habegger et al.   Nature Reviews Endocrinology

Effects of Type 2 Diabetes on Insulin Secretion, Insulin Action, Glucose Effectiveness, and Postprandial Glucose Metabolism

(2009) A. Basu et al.   DIABETES CARE

Dipeptidyl Peptidase-4 Inhibition by Vildagliptin and the Effect on Insulin Secretion and Action in Response to Meal Ingestion in Type 2 Diabetes

(2008) C. Dalla Man et al.   DIABETES CARE