Journal
DEVELOPMENTAL DYNAMICS
Volume 249, Issue 3, Pages 383-409Publisher
WILEY
DOI: 10.1002/dvdy.160
Keywords
-
Categories
Funding
- Air Force Office of Scientific Research [FA9550-14-1-0060]
- National Institues of Health [P50-GM-076516]
- National Science Foundation [DMS-1129008, DMS176-3272]
- Simons Foundation [DMS-176-3272]
Ask authors/readers for more resources
Elaborate regulatory feedback processes are thought to make biological development robust, that is, resistant to changes induced by genetic or environmental perturbations. How this might be done is still not completely understood. Previous numerical simulations on reaction-diffusion models of Dpp gradients in Drosophila wing imaginal disc have showed that feedback (of the Hill function type) on (signaling) receptors and/or non-(signaling) receptors are of limited effectiveness in promoting robustness. Spatial nonuniformity of the feedback processes has also been shown theoretically to lead to serious shape distortion and a principal cause for ineffectiveness. Through mathematical modeling and analysis, the present article shows that spatially uniform nonlocal feedback mechanisms typically modify gradient shape through a shape parameter (that does not change with location). This in turn enables us to uncover new multi-feedback instrument for effective promotion of robust signaling gradients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available