The Rheb-TORC1 signaling axis functions as a developmental checkpoint

Ras-Dependent Cell Fate Decisions Are Reinforced by the RAP-1 Small GTPase in Caenorhabditis elegans

(2018) Neal R. Rasmussen et al.   GENETICS

Ral Signals through a MAP4 Kinase-p38 MAP Kinase Cascade in C. elegans Cell Fate Patterning

(2018) Hanna Shin et al.   Cell Reports

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

(2017) David M. Sabatini   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A microRNA program in theC. eleganshypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport

(2016) Robert H. Dowen et al.   GENES & DEVELOPMENT

Starvation-Induced Stress Response Is Critically Impacted by Ceramide Levels in Caenorhabditis elegans

(2016) Mingxue Cui et al.   GENETICS

Cell size and fat content of dietary-restrictedCaenorhabditis elegansare regulated by ATX-2, an mTOR repressor

(2016) Daniel Z. Bar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TOR Complexes and the Maintenance of Cellular Homeostasis

(2016) Sandra Eltschinger et al.   TRENDS IN CELL BIOLOGY

Starvation-Induced Stress Response Is Critically Impacted by Ceramide Levels in Caenorhabditis elegans

(2016) Mingxue Cui et al.   GENETICS

The C. elegans Hypodermis Couples Progenitor Cell Quiescence to the Dietary State

(2015) Masamitsu Fukuyama et al.   CURRENT BIOLOGY

The auxin-inducible degradation (AID) system enables versatile conditional protein depletion in C. elegans

(2015) L. Zhang et al.   DEVELOPMENT

Streamlined Genome Engineering with a Self-Excising Drug Selection Cassette

(2015) Daniel J. Dickinson et al.   GENETICS

Streamlined Genome Engineering with a Self-Excising Drug Selection Cassette

(2015) Daniel J. Dickinson et al.   GENETICS

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins

(2014) Qiaoli Chen et al.   CELLULAR SIGNALLING

Scalable and Versatile Genome Editing Using Linear DNAs with Microhomology to Cas9 Sites in Caenorhabditis elegans

(2014) Alexandre Paix et al.   GENETICS

Rapid and Precise Engineering of the Caenorhabditis elegans Genome with Lethal Mutation Co-Conversion and Inactivation of NHEJ Repair

(2014) Jordan D. Ward   GENETICS

High- and low-throughput scoring of fat mass and body fat distribution in C. elegans

(2014) Carolina Wählby et al.   METHODS

Ral and Rheb GTPase Activating Proteins Integrate mTOR and GTPase Signaling in Aging, Autophagy, and Tumor Cell Invasion

(2014) Timothy D. Martin et al.   MOLECULAR CELL

κB-Ras Proteins Regulate Both NF-κB-Dependent Inflammation and Ral-Dependent Proliferation

(2014) Andrea Oeckinghaus et al.   Cell Reports

An RNAi-Based Suppressor Screen Identifies Interactors of the Myt1 Ortholog of Caenorhabditis elegans

(2014) Anna K. Allen et al.   G3-Genes Genomes Genetics

Identification of Late Larval Stage Developmental Checkpoints in Caenorhabditis elegans Regulated by Insulin/IGF and Steroid Hormone Signaling Pathways

(2014) Adam J. Schindler et al.   PLoS Genetics

Rheb and Rags come together at the lysosome to activate mTORC1: Figure 1

(2013) Marlous J. Groenewoud et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Negative Regulation of the RalGAP Complex by 14-3-3

(2013) Dara Leto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination

(2013) Daniel J Dickinson et al.   NATURE METHODS

The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

(2013) Louis R. Lapierre et al.   Nature Communications

Germline Signaling Mediates the Synergistically Prolonged Longevity Produced by Double Mutations in daf-2 and rsks-1 in C. elegans

(2013) Di Chen et al.   Cell Reports

A novel sphingolipid-TORC1 pathway critically promotes postembryonic development in Caenorhabditis elegans

(2013) Huanhu Zhu et al.   eLife

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Downregulation of Ral GTPase-activating protein promotes tumor invasion and metastasis of bladder cancer

(2012) R Saito et al.   ONCOGENE

C. elegansAMPKs promote survival and arrest germline development during nutrient stress

(2012) Masamitsu Fukuyama et al.   Biology Open

Evolution of the TOR Pathway

(2011) Teunis J. P. van Dam et al.   JOURNAL OF MOLECULAR EVOLUTION

OASIS: Online Application for the Survival Analysis of Lifespan Assays Performed in Aging Research

(2011) Jae-Seong Yang et al.   PLoS One

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

A Ral GAP complex links PI 3-kinase/Akt signaling to RalA activation in insulin action

(2010) Xiao-Wei Chen et al.   MOLECULAR BIOLOGY OF THE CELL

Manipulation of Behavioral Decline in Caenorhabditis elegans with the Rag GTPase raga-1

(2010) Matthew A. Schreiber et al.   PLoS Genetics

C. elegans Major Fats Are Stored in Vesicles Distinct from Lysosome-Related Organelles

(2009) Eyleen J. O'Rourke et al.   Cell Metabolism

Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

(2008) Sakiko Honjoh et al.   NATURE

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Phagocytic Receptor CED-1 Initiates a Signaling Pathway for Degrading Engulfed Apoptotic Cells

(2008) Xiaomeng Yu et al.   PLOS BIOLOGY