Article
Critical Care Medicine
Jonathan E. Elliott, Nadir M. Balba, Alisha A. McBride, Megan L. Callahan, Kendall T. Street, Matthew P. Butler, Mary M. Heinricher, Miranda M. Lim
Summary: This study examined the effectiveness of different methods for evaluating history of traumatic brain injury (TBI), finding that the Head Trauma Events Characteristics (HTEC) method had the highest sensitivity. It also noted that the results and conclusions may significantly differ depending on the diagnostic method used.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Clinical Neurology
Andrea L. C. Schneider, Carrie B. Peltz, Yixia Li, Amber Bahorik, Raquel C. Gardner, Kristine Yaffe
Summary: This study found that traumatic brain injury (TBI) is associated with long-term stroke risk, with differences observed in age, sex, race and ethnicity, and time since TBI diagnosis. The highest risk of stroke occurs in the first year after TBI diagnosis, but the risk remains elevated for more than 10 years. Both mild and moderate/severe/penetrating TBI increase the risk of stroke compared to individuals without TBI. Older individuals have a stronger association between TBI and stroke, while Black veterans have a weaker association compared to other races and ethnicities. These findings suggest that veterans with prior TBI should be targeted for primary stroke prevention measures.
Review
Medicine, General & Internal
Ioannis Mavroudis, Alin Ciobica, Alina Costina Luca, Ioana-Miruna Balmus
Summary: Post-traumatic headache (PTH) is a common and debilitating consequence of mild traumatic brain injury (mTBI) that can occur over one year after the head impact event. Understanding the pathophysiology and risk factors of PTH is crucial for early identification and management. Risk factors for PTH include history of migraines or headaches, female gender, younger age, greater severity of the head injury, and co-occurring psychological symptoms. PTH can present in various clinical profiles and treatment options include pharmacological interventions and non-pharmacological approaches such as cognitive behavioral therapy and physical therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Katherine Musacchio Schafer, Emma Wilson, Thomas Joiner
Summary: Suicide is a widespread public health concern, with traumatic brain injuries (TBIs) and lack of social integration identified as risk factors. This cross-sectional study of 1469 military Veterans found that TBI was negatively associated with social integration and positively with suicidality. Social integration was also negatively associated with suicidality. The study suggests that lack of social integration may promote suicidality in the context of TBI and highlights the potential use of social integration as an intervention for suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Kasper Lolk, Julie W. Dreier, Jakob Christensen
Summary: The study found that the risk of epilepsy following traumatic brain injury increases with the repetition and severity of the injury, with females more likely to develop epilepsy after mild injuries and males more likely after severe injuries. These risks remain elevated for decades post-injury.
Article
Clinical Neurology
Josh W. Faulkner, Alice Theadom, Deborah L. Snell, Matt N. Williams
Summary: This study applied network analysis to investigate post-concussion symptoms after mild traumatic brain injury (mTBI) and found that frustration, blurred vision, and concentration difficulties were central symptoms in two different mTBI samples. These symptoms may play an influential role in the experience and maintenance of post-concussion symptoms.
FRONTIERS IN NEUROLOGY
(2023)
Review
Clinical Neurology
Patrick T. Quaid, Eric L. Singman
Summary: This study describes the various headache types seen after brain injury and demonstrates their impact on the visual system. The results of the study indicate that almost every type of headache is directly or indirectly related to the visual system.
NEUROREHABILITATION
(2022)
Article
Clinical Neurology
Assefa Agegnehu Teshome, Gashaw Walle Ayehu, Getachew Yideg Yitbark, Endeshaw Chekol Abebe, Misganaw Asmamaw Mengstie, Mohammed Abdu Seid, Yalew Melkamu Molla, Nega Dagnaw Baye, Tadeg Jemere Amare, Agmas Wassie Abate, Taklo Semineh Yazie, Kidist Hunegn Setargew
Summary: The prevalence and associated factors of post-concussion syndrome among patients with traumatic brain injury were assessed at Debre Tabor Comprehensive Hospital. The study found that over 41.5% of participants experienced at least three symptoms of PCS. Factors such as the Glasgow coma scale level at presentation, the cause of injury, social support, and the site of injury were significantly associated with the occurrence of PCS.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Hakan Ashina, David W. Dodick
Summary: This review discusses the pharmacologic management of post-traumatic headache and the potential therapeutic benefits of targeting calcitonin gene-related peptide signaling. It suggests using a phenotype-guided approach for treatment based on the primary headache phenotype that the clinical features resemble the most. Additionally, advancements are being made in identifying cellular and molecular drivers of headache persistence.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Medicine, General & Internal
Sophia Wagberg, Britt-Marie Stalnacke, Beatrice M. M. Magnusson
Summary: This study evaluates post-TBI symptoms and disabilities seven to eight years after mild TBI (mTBI), showing that women and individuals with repeated TBI experience more severe symptoms and functional decline. These findings have implications for clinical practice and research, and should be considered in rehabilitation and follow-up plans.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Clinical Neurology
Todd J. Schwedt
Summary: Post-traumatic headache is a common and persistent symptom following mild traumatic brain injury, with onset typically within 7 days post-injury. Pathophysiological mechanisms of post-traumatic headache involve structural, functional, metabolic, and neuroinflammatory factors. Effective therapy options are currently lacking, with future research priorities including optimizing diagnostic criteria and understanding pathophysiology.
Article
Psychology, Multidisciplinary
Ashley N. Clausen, Heather C. Bouchard, Kathleen A. Welsh-Bohmer, Rajendra A. Morey
Summary: This study compared the chronic effects of combat-related blast mTBI and subconcussive blast exposure on neuropsychological performance in Veterans. Results showed that Veterans with combat-related blast mTBI exhibited significantly slower processing speed compared to controls, even after controlling for PTSD and depressive symptoms. However, there were no significant differences in cognition between subconcussive and control groups, or between subconcussive and combat-related blast mTBI groups, suggesting that neurocognitive assessment may not be sensitive enough to detect the long-term effects of subconcussive blast exposure.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Critical Care Medicine
Emily R. Fisher, Janelle J. Montroy, Gerardo Duque, Charles S. Cox, Linda Ewing-Cobbs
Summary: This study investigated the persistence of PCS and PTSS in children and adolescents following TBI and EI, finding that the two types of symptoms varied among different TBI severity groups. Shared vulnerability factors included female sex, milder TBI, and poorer pre-injury adjustment, while older age was a unique vulnerability factor for PTSS.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Roh-Eul Yoo, Seung Hong Choi, Sung-Won Youn, Moonjung Hwang, Eunkyung Kim, Byung-Mo Oh, Ji Ye Lee, Inpyeong Hwang, Koung Mi Kang, Tae Jin Yun, Ji-Hoon Kim, Chul-Ho Sohn
Summary: This study found that mTBI patients with PCS had lower average MVF in the bilateral cerebral WM compared to controls, as well as significantly decreased myelin volume in the corpus callosum and brainstem. Total myelin volume was also reduced in these patients. Additionally, there was a significant correlation between myelin volume and neuropsychological test scores only in the bilateral cerebral WM and verbal learning test.
KOREAN JOURNAL OF RADIOLOGY
(2022)
Article
Rehabilitation
Sandra E. Rakers, Marieke E. Timmerman, Myrthe E. Scheenen, Myrthe E. de Koning, Harm J. van der Horn, Joukje van der Naalt, Jacoba M. Spikman
Summary: The study analyzed fatigue after mild traumatic brain injury (TBI) using latent class growth analysis (LCGA) to identify distinct recovery trajectories and investigate influencing factors. Results showed four patient clusters with different patterns of fatigue, emotional distress, and coping styles. Favorable recovery from posttraumatic fatigue was observed in 55% of mild TBI patients.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2021)
Article
Neurosciences
Gabriella A. M. Blokland, Jakob Grove, Chia-Yen Chen, Chris Cotsapas, Stuart Tobet, Robert Handa, David St Clair, Todd Lencz, Bryan J. Mowry, Sathish Periyasamy, Murray J. Cairns, Paul A. Tooney, Jing Qin Wu, Brian Kelly, George Kirov, Patrick F. Sullivan, Aiden Corvin, Brien P. Riley, Tonu Esko, Lili Milani, Erik G. Jonsson, Aarno Palotie, Hannelore Ehrenreich, Martin Begemann, Agnes Steixner-Kumar, Pak C. Sham, Nakao Iwata, Daniel R. Weinberger, Pablo Gejman, Alan R. Sanders, Joseph D. Buxbaum, Dan Rujescu, Ina Giegling, Bettina Konte, Annette M. Hartmann, Elvira Bramon, Robin M. Murray, Michele T. Pato, Jimmy Lee, Ingrid Melle, Espen Molden, Roel A. Ophoff, Andrew McQuillin, Nicholas J. Bass, Rolf Adolfsson, Anil K. Malhotra, Nicholas G. Martin, Janice M. Fullerton, Philip B. Mitchell, Peter R. Schofield, Andreas J. Forstner, Franziska Degenhardt, Sabrina Schaupp, Ashley L. Comes, Manolis Kogevinas, Jose Guzman-Parra, Andreas Reif, Fabian Streit, Lea Sirignano, Sven Cichon, Maria Grigoroiu-Serbanescu, Joanna Hauser, Jolanta Lissowska, Fermin Mayoral, Bertram Muller-Myhsok, Thomas G. Schulze, Markus M. Nothen, Marcella Rietschel, John Kelsoe, Marion Leboyer, Stephane Jamain, Bruno Etain, Frank Bellivier, John B. Vincent, Martin Alda, Claire O'Donovan, Pablo Cervantes, Joanna M. Biernacka, Mark Frye, Susan L. McElroy, Laura J. Scott, Eli A. Stahl, Mikael Landen, Marian L. Hamshere, Olav B. Smeland, Srdjan Djurovic, Arne E. Vaaler, Ole A. Andreassen, Bernhard T. Baune, Tracy Air, Martin Preisig, Rudolf Uher, Douglas F. Levinson, Myrna M. Weissman, James B. Potash, Jianxin Shi, James A. Knowles, Roy H. Perlis, Susanne Lucae, Dorret Boomsma, Brenda W. J. H. Penninx, Jouke-Jan Hottenga, Eco J. C. de Geus, Gonneke Willemsen, Yuri Milaneschi, Henning Tiemeier, Hans J. Grabe, Alexander Teumer, Sandra Van der Auwera, Uwe Volker, Steven P. Hamilton, Patrik K. E. Magnusson, Alexander Viktorin, Divya Mehta, Niamh Mullins, Mark J. Adams, Gerome Breen, Andrew M. McIntosh, Cathryn M. Lewis, David M. Hougaard, Merete Nordentoft, Ole Mors, Preben B. Mortensen, Thomas Werge, Thomas D. Als, Anders D. Borglum, Tracey L. Petryshen, Jordan W. Smoller, Jill M. Goldstein
Summary: The study found significant sex-dependent genetic risk in schizophrenia, major depressive disorder, and bipolar disorder, with implications for genes related to neuronal development, immune functions, and vascular functions across and within these disorders. This suggests substantial genetic overlap between sexes in mood and psychotic disorders, with sex-specific effects enriched for genes involved in various physiological functions.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Biochemical Research Methods
Robert Warmerdam, Pauline Lanting, Patrick Deelen, Lude Franke
Summary: Identifying sample mix-ups in biobanks is crucial in utilizing genetic data for clinical pharmacogenetics. Existing methods are limited to datasets with additional omics data. This study introduces a method, Idefix, which uses polygenic scores to identify accidental sample mix-ups. By comparing actual phenotypes to polygenic scores, it achieves a substantial improvement over existing methods.
Article
Critical Care Medicine
Jackie Patterson, Sara Berkelhamer, Daniel Ishoso, Pooja Iyer, Casey Lowman, Melissa Bauserman, Joar Eilevstjonn, Ingunn Haug, Adrien Lokangaka, Beena Kamath-Rayne, Eric Mafuta, Helge Myklebust, Tracy Nolen, Janna Patterson, Nalini Singhal, Antoinette Tshefu, Carl Bose
Summary: This study evaluated the effectiveness of resuscitation training and continuous electronic heart rate monitoring in identifying stillbirths. The results showed that these interventions did not reduce the incidence of stillbirths and led to an increase in macerated stillbirths, deaths before discharge, and perinatal deaths. Expert review also revealed misclassification of stillbirths, with 20% of newborns classified as stillborn actually being liveborn.
Article
Psychology, Biological
Michael T. Bardo, Cassie M. Chandler, Emily D. Denehy, Benjamin A. Carper, Mark A. Prendergast, Tracy L. Nolen
Summary: This study examines the effect of the glucocorticoid receptor antagonist PT150 on fentanyl self-administration in male and female rats exposed to early-life stress. The results show that PT150 can decrease opioid intake in males and increase it in females, eliminating the sex difference in self-administration. This suggests that PT150 may be a useful treatment for opioid use disorder in males, but further research is needed to understand its effects in females.
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Obstetrics & Gynecology
Robert I. Goldenberg, Sarah Saleem, Sk Masum Billah, Jean Kim, Janet L. Moore, Najia Karim Ghanchi, Rashidul Haque, Lester Figueroa, Alejandra Ayala, Adrien Lokangaka, Antoinette Tshefu, Shivaprasad S. Goudar, Avinash Kavi, Manjunath Somannavar, Fabian Esamai, Musaku Mwenechanya, Elwyn Chomba, Archana Patel, Prabir Das, Wilfred Injera Emonyi, Samuel Edidi, Madhavi Deshmukh, Biplob Hossain, Shahjahan Siraj, Manolo Mazariegos, Ana L. Garces, Melissa Bauserman, Carl L. Bose, William A. Petri, Nancy F. Krebs, Richard J. Derman, Waldemar A. Carlo, Edward A. Liechty, Patricia L. Hibberd, Marion Koso-Thomas, Nalini Peres-da-Silva, Tracy L. Nolen, Elizabeth M. McClure
Summary: This study aimed to determine the COVID-19 antibody positivity rates over time and its relationship to pregnancy outcomes in low- and middle-income countries. The results showed that the COVID-19 antibody positivity increased during pregnancy, but most adverse pregnancy outcomes were not significantly associated with antibody positivity.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Neurosciences
Bryan Cruz, Valentina Vozella, Benjamin A. Carper, Joy C. Xu, Dean Kirson, Shawn Hirsch, Tracy Nolen, Lauren Bradley, Katie Fain, Meg Crawford, Thomas R. Kosten, Eric P. Zorrilla, Marisa Roberto
Summary: Post-traumatic stress disorder (PTSD) leads to increased alcohol intake and development of alcohol use disorder (AUD). By identifying shared neural mechanisms, new therapies for PTSD/AUD can be discovered. This study used a rat model to evaluate compounds that inhibit FK506-binding protein 51 (FKBP5), a co-chaperone modulator of glucocorticoid receptors implicated in stress-related disorders. The results showed that FKBP5 inhibitors can modulate stress-related alcohol intake and trauma-related behaviors.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Koen F. Dekkers, Roderick C. Slieker, Andreea Ioan-Facsinay, Maarten van Iterson, M. Arfan Ikram, Marleen M. J. van Greevenbroek, Jan H. Veldink, Lude Franke, Dorret I. Boomsma, P. Eline Slagboom, J. Wouter Jukema, Bastiaan T. Heijmans
Summary: Circulating lipids can alter immune cell function, which may be relevant to lipid-associated inflammatory diseases. Through transcriptome-wide association analysis and Mendelian randomization analysis, we identified genes that are affected by blood triglycerides and HDL cholesterol, and found that triglycerides downregulate lipid metabolism and allergic response. Additionally, these genes were found to affect the incidence of allergic diseases. This highlights the interplay between triglycerides and immune cells in allergic disease.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Floranne Boulogne, Laura R. Claus, Henry Wiersma, Roy Oelen, Floor Schukking, Niek de Klein, Shuang Li, Harm-Jan Westra, Bert van der Zwaag, Franka van Reekum, Dana Sierks, Ria Schoenauer, Zhigui Li, Emilia K. Bijlsma, Willem Jan W. Bos, Jan Halbritter, Nine V. A. M. Knoers, Whitney Besse, Patrick Deelen, Lude Franke, Albertien M. van Eerde
Summary: Researchers have developed KidneyNetwork, a method that utilizes tissue-specific expression to prioritize candidate genes for kidney diseases. By integrating kidney RNA-sequencing co-expression network with a multi-tissue network, KidneyNetwork predicts genes related to kidney disease phenotypes using expression patterns and gene-phenotype associations. Applying KidneyNetwork to patients with undiagnosed kidney disease, it accurately predicts kidney-specific gene functions and identifies ALG6 as a plausible candidate gene for kidney and liver cysts.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Genetics & Heredity
Niek de Klein, Ellen A. Tsai, Martijn Vochteloo, Denis Baird, Yunfeng Huang, Chia-Yen Chen, Sipko van Dam, Roy Oelen, Patrick Deelen, Olivier B. Bakker, Omar El Garwany, Zhengyu Ouyang, Eric E. Marshall, Maria I. Zavodszky, Wouter van Rheenen, Mark K. Bakker, Jan Veldink, Tom R. Gaunt, Heiko Runz, Lude Franke, Harm-Jan Westra
Summary: This study utilized RNA-sequencing samples from multiple brain datasets to identify cis- and trans-expression quantitative trait loci (eQTLs) and potential drivers for brain-related diseases.
Article
Medicine, General & Internal
Alan T. N. Tita, Waldemar A. Carlo, Elizabeth M. McClure, Musaku Mwenechanya, Elwyn Chomba, Jennifer J. Hemingway-Foday, Avinash Kavi, Mrityunjay C. Metgud, Shivaprasad S. Goudar, Richard Derman, Adrien Lokangaka, Antoinette Tshefu, Melissa Bauserman, Carl Bose, Poonam Shivkumar, Manju Waikar, Archana Patel, Patricia L. Hibberd, Paul Nyongesa, Fabian Esamai, Osayame A. Ekhaguere, Sherri Bucher, Saleem Jessani, Shiyam S. Tikmani, Sarah Saleem, Robert L. Goldenberg, Sk M. Billah, Ruth Lennox, Rashidul Haque, William Petri, Lester Figueroa, Manolo Mazariegos, Nancy F. Krebs, Janet L. Moore, Tracy L. Nolen, Marion Koso-Thomas
Summary: In women planning a vaginal delivery, a single oral dose of azithromycin significantly reduced the risk of maternal sepsis or death compared to placebo, but had little effect on newborn sepsis or death.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Multidisciplinary Sciences
Qile Dai, Geyu Zhou, Hongyu Zhao, Urmo Vosa, Lude Franke, Alexis Battle, Alexander Teumer, Terho Lehtimaki, Olli T. Raitakari, Tonu Esko, Michael P. Epstein, Jingjing Yang
Summary: Most TWAS tools require individual-level eQTL reference data, making them not suitable for summary-level reference eQTL datasets. Hence, the development of TWAS methods that can utilize summary-level reference data is valuable. In this study, a TWAS framework called OTTERS is introduced, which adapts multiple polygenic risk score methods to estimate eQTL weights from summary-level data and performs omnibus TWAS. Both simulations and application studies demonstrate the practicality and power of OTTERS as a TWAS tool.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Albert Manasyan, Ariel A. Salas, Tracy Nolen, Elwyn Chomba, Manolo Mazariegos, Antoinette Tshefu Kitoto, Sarah Saleem, Farnaz Naqvi, K. Michael Hambidge, Norman Goco, Elizabeth M. McClure, Jan L. Wallander, Fred J. Biasini, Robert L. Goldenberg, Carl L. Bose, Marion Koso-Thomas, Nancy F. Krebs, Waldemar A. Carlo
Summary: This study compared the performance of the Ages and Stages Questionnaire (ASQ) and the Bayley Scales of Infant Development (BSID) second edition as screening tools for neurodevelopmental disorders in low-resource countries. The results showed that ASQ had high specificity but low sensitivity in 18-month-old infants. Therefore, when administered by trained healthcare workers, ASQ may be a useful screening tool.
Article
Immunology
Collins K. Boahen, Roy Oelen, Kieu Le, Mihai G. Netea, Lude Franke, Monique G. P. van der Wijst, Vinod Kumar
Summary: Both gene expression and protein concentrations are regulated by genetic variants. Exploring the regulation of eQTLs and pQTLs simultaneously in a context- and cell-type dependent manner may help unravel the mechanistic basis for genetic regulation of pQTLs. By conducting meta-analysis of Candida albicans-induced pQTLs from two population-based cohorts and intersecting the results with Candida-induced cell-type specific expression association data (eQTL), we found systematic differences between pQTLs and eQTLs, indicating the limitation of using eQTLs as a proxy for pQTLs. Additionally, our study identified SNPs affecting protein networks and implicated specific genomic loci through colocalization of pQTLs and eQTLs signals.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Jackie K. Patterson, Vanessa R. Thorsten, Barry Eggleston, Tracy Nolen, Adrien Lokangaka, Antoinette Tshefu, Shivaprasad S. Goudar, Richard J. Derman, Elwyn Chomba, Waldemar A. Carlo, Manolo Mazariegos, Nancy F. Krebs, Sarah Saleem, Robert L. Goldenberg, Archana Patel, Patricia L. Hibberd, Fabian Esamai, Edward A. Liechty, Rashidul Haque, Bill Petri, Marion Koso-Thomas, Elizabeth M. McClure, Carl L. Bose, Melissa Bauserman
Summary: Low birth weight (LBW) infants are at risk for death and disability, especially in low- and middle-income countries (LMICs) with limited access to advanced neonatal care. Predictive modeling can help identify high-risk mothers and facilitate referral to appropriate centers. Logistic regression performed best in predicting LBW using clinical variables available prior to delivery.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Jennifer Hemingway-Foday, Alan Tita, Elwyn Chomba, Musaku Mwenechanya, Trecious Mweemba, Tracy Nolen, Adrien Lokangaka, Antoinette Tshefu Kitoto, Gustave Lomendje, Patricia L. Hibberd, Archana Patel, Prabir Kumar Das, Kunal Kurhe, Shivaprasad S. Goudar, Avinash Kavi, Mrityunjay Metgud, Sarah Saleem, Shiyam S. Tikmani, Fabian Esamai, Paul Nyongesa, Amos Sagwe, Lester Figueroa, Manolo Mazariegos, Sk Masum Billah, Rashidul Haque, Md Shahjahan Siraj, Robert L. Goldenberg, Melissa Bauserman, Carl Bose, Edward A. Liechty, Osayame A. Ekhaguere, Nancy F. Krebs, Richard Derman, William A. Petri, Marion Koso-Thomas, Elizabeth Mcclure, Waldemar A. Carlo
Summary: Maternal and neonatal infections are a common cause of mortality. A clinical trial showed that oral azithromycin reduced certain infections in women during labor. This study aims to evaluate the impact of azithromycin given to women in labor on maternal and newborn outcomes.
