Article
Dentistry, Oral Surgery & Medicine
R. A. T. Noschang, D. Seebold, R. Walter, A. Rivera-Concepcion, I. A. Alraheam, M. Cardoso, P. A. Miguez
Summary: The study showed that SLRP proteins have positive effects on dentrin bonding and remineralization, with full proteoglycans containing GAGs significantly improving bonding over time.
Article
Engineering, Biomedical
Umer Daood, Amr Fawzy
Summary: The aim of this study is to evaluate the development of an experimental multi-mode/Universal resin-based dentin adhesive modified with synthetic Mg2+ doped hydroxyapatite crystals (HAp) that have self-remineralization and antibiofilm properties. The experimental adhesive was tested for degree of conversion, X-ray diffraction, bond strength, electron microscopy imaging, nanoleakage, nanoindentation, confocal analysis, and Raman analysis. The effects of the modified adhesive on S. mutans, nucleating abilities, alkaline phosphatase, Runx2, Ocn transcripts, and level of mineralization were investigated. The experimental dentin adhesive with 0.5% Hap/Mg2+ demonstrated improved interaction with dentin and showed preservation of a uniform intact hybrid layer with the absence of nanoleakage, indicating dentin bond integrity.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Anton Schestakow, Christina Bauer, Matthias Hannig
Summary: This study investigated the ultrastructure and erosion protective properties of the dentin pellicle. The results showed that the dentin pellicle is not acid-resistant and cannot effectively protect dentin from erosion.
Article
Dentistry, Oral Surgery & Medicine
Manuel Toledano, Fatima S. Aguilera, Estrella Osorio, Manuel Toledano-Osorio, Germaine Escames, Antonio L. Medina-Castillo, Raquel Toledano, Christopher D. Lynch, Raquel Osorio
Summary: The study investigated the effectiveness of novel polymeric nanoparticles doped with melatonin in reducing dentin permeability and facilitating dentin remineralization after endodontic treatment. Results showed that melatonin-doped nanoparticles effectively sealed dentinal tubules, strengthened the structure of radicular dentin, and promoted durable remineralization. This may provide a new approach for improving root canal treatment outcomes.
Article
Dentistry, Oral Surgery & Medicine
Tainah Oliveira Rifane, Karen Evellin Moura Cordeiro, Francisbenia Alves Silvestre, Marina Trevelin Souza, Edgar Dutra Zanotto, Vitaliano Gomes Araujo-Neto, Marcelo Giannini, Salvatore Sauro, Diego Martins de Paula, Victor Pinheiro Feitosa
Summary: The objective of this study is to analyze the effects of simplified adhesives containing pure or silanized bioglass 45S5 or Sr-45S5 fillers on dentin. The results showed that the incorporation of silanized 45S5 bioglass into the adhesive improved dentin remineralization, bonding performance, and adhesive polymerization. However, the silanized Sr-45S5 compromised the bond strength, interface nanoleakage, and had a negative impact on HYP outcomes.
Article
Dentistry, Oral Surgery & Medicine
Manuel Toledano-Osorio, Fatima S. Aguilera, Esther Munoz-Soto, Estrella Osorio, Manuel Toledano, Germaine Escames, Antonio L. Medina-Castillo, Maria T. Osorio, Modesto T. Lopez-Lopez, Marta Vallecillo-Rivas, Raquel Osorio
Summary: The study showed that new polycrystalline formations encountered in dentin treated with ML-doped polymeric nanoparticles can lead to improved structural dentin stability and mechanical performance at the root.
Article
Engineering, Biomedical
Mustafa Gungormus, Fatih Tulumbaci
Summary: Bonding with dentin involves a complex process of physical and chemical adhesion, requiring the adhesive to penetrate and envelop collagen fibers. Acid etching clears debris from dentin but also exposes susceptible mineral-free collagen fibers. Researchers have developed a rapid remineralization approach to restore the mineral content of etched dentin, improving mechanical properties and stability. Future studies will further validate the benefits of this method for clinical applications.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Materials Science, Ceramics
Ahmed Samir Bakry, Nuha Al-Harbi, Yas Al-Hadeethi, Mona A. Abbassy, N. K. Katturi, B. Xin, I. S. Roqan, Hiba Mohammed, Robert Hill
Summary: The study aimed to evaluate the effectiveness of BioMin C and BioMin F in treating dentin hypersensitivity. Dentin surfaces were treated, and then covered with BioMin C and BioMin F pastes, followed by an acid challenge. The coverage percentages of bioactive materials before and after the erosion challenge were compared. Chemical analyses were performed using Raman spectroscopy, X-ray diffraction, and scanning electron microscopy. The specimens treated with the bioactive pastes showed complete coverage with a crystalline layer. The erosive acid challenge did not significantly affect the dentin coverage percentage. The crystalline layer formed by BioMin C contained hydroxyapatite crystals, while that formed by BioMin F paste contained brushite crystals. These tested pastes may be beneficial in treating dentin hypersensitivity.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2023)
Article
Nanoscience & Nanotechnology
Beibei Wang, Fei Han, Ran You, Chen Chen, Haifeng Xie
Summary: The objective of this study was to investigate the effects of proanthocyanidins (PA), myricetin, resveratrol, and kaempferol on dentin collagen modification and MMP activity inhibition, as well as their contributions to biomimetic remineralization and resin-dentin bonding performance. The results showed that these four polyphenols can modify dentin collagen, inhibit MMP activity, promote biomimetic remineralization, and improve resin-dentin bond durability.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Y. Li, L. Wu, Q. Wang, Q. Zhou, C. Y. Cao, S. Zheng, Z. Zhou, H. M. Wong, Q. L. Li
Summary: This study introduces a novel biomimetic-mineralizing strategy, PDA@PAA, to induce self-healing of dentin defects, showing promising potential in repairing demineralized dentin with similar tooth structure.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Engineering, Biomedical
Manuel Toledano, Raquel Osorio, Marta Vallecillo-Rivas, Estrella Osorio, Christopher D. Lynch, Fatima S. Aguilera, Raquel Toledano, Salvatore Sauro
Summary: This study aimed to explore the role of zinc-doped cements in promoting dentin remineralization through a literature review, finding that zinc enhances the bioactivity and mineralization of dentin, leading to increased hardness and resistance to deformation. Oxipatite-based cements mechanically reinforce dentin structure, promoting remineralization, but also result in high solubility and instability due to the formation of immature crystallites.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Physical
Qi Zhang, Jiaxin Guo, Zihua Huang, Sui Mai
Summary: This study found that carboxymethyl chitosan (CMC) can promote mineralization and remineralization of carious dentin, improving bond performance and durability. These findings have important potential implications for treating deep caries.
Article
Chemistry, Applied
Haiyan Wu, Changyu Shao, Jue Shi, Zihe Hu, Yanyan Zhou, Zhuo Chen, Ruikang Tang, Zhijian Xie, Wenjing Jin
Summary: Non-collagenous proteins (NCPs) embedded in hyaluronic acid (HA) play a crucial role in regulating collagen fibril mineralization in bone and dentin extracellular matrix (ECM). Through reducing the electronegativity of collagen surface and providing additional nucleation sites, HA promotes intrafibrillar collagen mineralization and accelerates the crystallization process. The effects of HA on collagen mineralization are observed in collagen hydrogel and in vitro dentin remineralization, demonstrating its potential as a biomaterial for repairing collagen mineralized tissues.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Physical
Hyun-Jung Kim, Ji-Hyun Jang, Sang Uk Woo, Kyoung-Kyu Choi, Sun-Young Kim, Jack L. Ferracane, Jung-Hwan Lee, Dongseok Choi, Samjin Choi, Soogeun Kim, Ayoung Bang, Duck-Su Kim
Summary: The study found that the novel BAG-containing dentin adhesive has the potential to reduce the permeability of demineralized dentin and promote dentin remineralization.
Article
Dentistry, Oral Surgery & Medicine
Manuel Toledano, Estrella Osorio, Maria T. Osorio, Fatima S. Aguilera, Raquel Toledano, Enrique Fernandez-Romero, Raquel Osorio
Summary: This study evaluated the bonding ability and mechanical and chemical behavior of demineralized dentin infiltrated with polymeric nanoparticles doped with dexamethasone. The results showed that dexamethasone nanoparticles improved the nanohardness and Young's modulus of dentin, and promoted remineralization and improved the structure of collagen.
JOURNAL OF DENTISTRY
(2023)
Review
Polymer Science
Manuel Toledano-Osorio, Manuel Toledano, Francisco Javier Manzano-Moreno, Cristina Vallecillo, Marta Vallecillo-Rivas, Alberto Rodriguez-Archilla, Raquel Osorio
Summary: The study concludes that using polymeric membranes for guided bone regeneration (GBR) is an effective technique for achieving horizontal bone augmentation, facilitating proper implant placement.
Review
Polymer Science
Manuel Toledano, Marta Vallecillo-Rivas, Maria T. Osorio, Esther Munoz-Soto, Manuel Toledano-Osorio, Cristina Vallecillo, Raquel Toledano, Christopher D. Lynch, Maria-Angeles Serrera-Figallo, Raquel Osorio
Summary: The study highlights the significant role of zinc-doped membranes in guided bone regeneration, showing their ability to inhibit bacterial colonization, promote bioactivity and bone regeneration, as well as demonstrating good biocompatibility and mechanical properties.
Article
Chemistry, Inorganic & Nuclear
Mari C. Manas-Torres, Gloria B. Ramirez-Rodriguez, Jose Garcia-Peiro, Belen Parra-Torrejon, Juan M. Cuerva, Modesto T. Lopez-Lopez, Luis Alvarez de Cienfuegos, Jose M. Delgado-Lopez
Summary: Self-assembled peptides and proteins are excellent templates for the growth of inorganic minerals, mimicking natural biomineralization processes. By utilizing specific peptides, simultaneous peptide self-assembly and mineralization processes can be achieved, leading to the development of complex materials with properties similar to those found in nature.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Acoustics
Mariia Savchenko, Manuel Hurtado, Modesto T. Lopez-Lopez, Guillermo Rus, Luis Alvarez de Cienfuegos, Juan Melchor, Jose A. Gavira
Summary: Sonocrystallization involves using ultrasound radiation to control nucleation and crystal growth, showing significant and reproducible effects on crystal size populations in gel media in protein crystallization research.
ULTRASONICS SONOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Md Wazedur Rahman, Mari C. Manas-Torres, Seyedamin Firouzeh, Sara Illescas-Lopez, Juan Manuel Cuerva, Modesto T. Lopez-Lopez, Luis Alvarez de Cienfuegos, Sandipan Pramanik
Summary: Supramolecular short-peptide assemblies are important biomaterials used in biomedical applications. These materials can self-assemble into chiral hierarchical structures triggered by various stimuli. The resulting supramolecular chirality can modulate protein and cell interactions. Recently, research has focused on developing chiral materials with potential spintronic applications. By combining different chiral sources, such as homochiral peptides and glucono-delta-lactone, researchers have shown that the supramolecular chirality and spin signal can be modulated. This study opens up new possibilities for developing CISS-based spintronic devices and circuits.
Review
Chemistry, Physical
Cristina Gila-Vilchez, Laura Rodriguez-Arco, Mari C. Manas-Torres, Luis Alvarez de Cienfuegos, Modesto T. Lopez-Lopez
Summary: Recent advances in the synthesis of supramolecular hydrogels focus on developing novel hybrid hydrogels by combining low molecular weight gelators (LMWGs) with different additives. These hybrid hydrogels exhibit interesting features, such as stimuli-responsiveness, gel-sol reversibility, self-healing, and thixotropy, making them attractive for biomedical and biotechnological applications. Magnetic nanoparticles can be incorporated into hydrogel matrices to create magnetic hydrogels, which have unique stimuli-responsive properties.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Manuel Toledano, Estrella Osorio, Fatima S. Aguilera, Marfa T. Osorio, Raquel Toledano, Modesto T. Lopez-Lopez, Christopher D. Lynch, Raquel Osorio
Summary: The study aims to investigate the effect of novel polymeric nanoparticles (NPs) doped with dexamethasone (Dex) on the viscoelasticity, crystallinity, and ultra-nanostructure of the formed hydroxyapatite after NPs dentin infiltration. The results showed that Dex-doped NPs exhibited higher complex, storage, and loss moduli at 21 days of storage time. Furthermore, Dex-NPs increased the fibril diameters of dentin collagen over time, while Zn-doped-Dex-NPs had the lowest nano-roughness values and highest crystallinity.
Article
Chemistry, Multidisciplinary
Mariia Savchenko, Victor Sebastian, Modesto Torcuato Lopez-Lopez, Alejandro Rodriguez-Navarro, Luis Alvarez De Cienfuegos, Concepcion Jimenez-Lopez, Jose Antonio Gavira
Summary: This article discusses the importance of crystallization in confined spaces for both natural processes and man-made materials. Studying nucleation in confined spaces can help us understand similar natural events, design new methods to control crystallization, and expand our knowledge in the field of crystallography.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Dentistry, Oral Surgery & Medicine
Manuel Toledano, Estrella Osorio, Maria T. Osorio, Fatima S. Aguilera, Raquel Toledano, Enrique Fernandez-Romero, Raquel Osorio
Summary: This study evaluated the bonding ability and mechanical and chemical behavior of demineralized dentin infiltrated with polymeric nanoparticles doped with dexamethasone. The results showed that dexamethasone nanoparticles improved the nanohardness and Young's modulus of dentin, and promoted remineralization and improved the structure of collagen.
JOURNAL OF DENTISTRY
(2023)
Article
Materials Science, Multidisciplinary
Cristina Gila-Vilchez, Mari Carmen Manas-Torres, Oscar Dario Garcia-Garcia, Alfredo Escribano-Huesca, Laura Rodriguez-Arco, Victor Carriel, Ismael Rodriguez, Miguel Alaminos, Modesto Torcuato Lopez-Lopez, Luis Alvarez de Cienfuegos
Summary: Fibrin hydrogels made from human plasma fibrinogen have excellent biocompatibility and biodegradability and are widely used in regenerative medicine. By combining fibrinogen with Fmoc-FF and Fmoc-RGD, we have developed composite hydrogels that have improved mechanical properties compared to pure fibrin gels. These composite gels show excellent biocompatibility in vitro and do not cause any inflammatory response or tissue damage in vivo, making them potential vehicles for drug or growth factor release.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Francisco J. Vazquez-Perez, Cristina Gila-Vilchez, Alberto Leon-Cecilla, Luis Alvarez de Cienfuegos, Dmitry Borin, Stefan Odenbach, James E. Martin, Modesto T. Lopez-Lopez
Summary: This paper demonstrates the fabrication and actuation of magnetic shape-memory materials based on hydrogels containing magnetic particles. The materials can change their shape and dimensions in response to external magnetic fields, allowing for bending or twisting.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Sara Illescas-Lopez, Javier D. Martin-Romera, Mari C. Manas-Torres, Modesto T. Lopez-Lopez, Juan M. Cuerva, Jose A. Gavira, Francisco J. Carmona, Luis Alvarez de Cienfuegos
Summary: The development of bio-MOFs or MOF biocomposites combines MOFs with biopolymers, expanding the potential applications of MOFs and creating greener and more bio-oriented composite materials. Short-peptide supramolecular hydrogels have been used as a medium to promote the growth of MOF particles, resulting in a new family of bio-MOFs. These bio-MOFs have great potential for biomedical uses such as tissue engineering and drug delivery.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Antonio L. Medina-Castillo, Modesto T. Lopez-Lopez, Maria Dolores Fernandez-Ramos
Summary: This paper presents, for the first time, the theoretical formulation of the distribution function of critical nuclei under Pre-Poly conditions. It also develops a simple empirical method to calculate the concentration of critical nuclei, which shows good agreement with theoretical calculations.
Article
Materials Science, Multidisciplinary
Cristina Gila-Vilchez, Mari Carmen Manas-Torres, Oscar Dario Garcia-Garcia, Alfredo Escribano-Huesca, Laura Rodriguez-Arco, Victor Carriel, Ismael Rodriguez, Miguel Alaminos, Modesto Torcuato Lopez-Lopez, Luis Alvarez de Cienfuegos
Summary: Fibrin hydrogels made by self-assembly of fibrinogen from human plasma are highly biocompatible and biodegradable. However, they have limited mechanical properties and are expensive to obtain. To address these issues, composite hydrogels made of fibrinogen, Fmoc-FF, and Fmoc-RGD were prepared. These composite gels exhibited improved mechanical properties compared to pure fibrin gels and showed excellent biocompatibility ex vivo. In vivo experiments showed that these gels do not cause inflammation or tissue damage and are completely resorbed, making them suitable for cell, drug, or growth factor release vehicles.
ACS APPLIED POLYMER MATERIALS
(2023)
Meeting Abstract
Cell & Tissue Engineering
Fernando Campos, Ismael A. Rodriguez, Modesto T. Lopez-Lopez, Carmen Gonzalez-Gallardo, Ricardo Fernandez-Valades, M. Carmen Sanchez-Quevedo, Ingrid Garzon, Miguel Alaminos, Antonio Campos, Victor Carriel
TISSUE ENGINEERING PART A
(2022)