Journal
CYTOKINE
Volume 127, Issue -, Pages -Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2019.154917
Keywords
Ganoderma lucidum; Triterpenes; Inflammation; NF-kappa B; MAPK
Funding
- Science and Technology Major Project of Inner Mongolia Autonomous Region of China
- State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock [zdzx2018065]
- Natural Science Foundation of Inner Mongolia [2017MSLH0310]
- Inner Mongolia University Startup Foundation for Advanced Talents [30500-5185139]
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Ganoderma lucidum is a popular medicinal mushroom, which has been used as therapeutic for centuries in traditional Chinese medicine. Although G. lucidum showed strong protective effects in prevention or treatment of a variety of inflammatory diseases, the mechanisms underlying the anti-inflammatory properties of triterpenes of G. lucidum remain undefined. In the current study, we demonstrated that ethanol extract and triterpenes of G. lucidum specifically suppressed LPS-mediated inflammatory responses. Notably, ganodermanontriol inhibited the expressions and interactions of TLR4 and MyD88, NE-kappa B translocation to nucleus and its DNA binding activity, phosphorylation of p38, ErK1/2 and JNK. In vivo, we showed that ganodermanontriol effectively prevented LPS/D-Galactosamine-induced liver injury by reducing TNF-alpha and IL-6 production, and decrease of ALT/AST release. Collectively, our results revealed a novel role in inhibition of inflammatory diseases for triterpenes that may act through potential inhibition of TLR4-MyD88-mediated NF-kappa B and MAPK signaling pathways.
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