Article
Psychiatry
Leonardo F. Fontenelle, Lucy Albertella, Mary-Ellen Brierley, Emma M. Thompson, Louise Destree, Sam R. Chamberlain, Murat Yucel
Summary: This study investigated the deterioration of symptoms of obsessive-compulsive and related disorders (OCRDs) during the COVID-19 pandemic, finding that factors such as being female, experiencing more COVID-19 related stressful events, and having higher compulsivity traits predicted worsened symptoms during the pandemic. Identifying a pre-pandemic profile of individuals most at risk of symptom deterioration may be valuable for future preventative initiatives related to COVID-19 or other communicable diseases. Future studies should follow up on these findings longitudinally.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Behrang Mahjani, Christina Gustavsson Mahjani, Abraham Reichenberg, Sven Sandin, Christina M. Hultman, Joseph D. Buxbaum, Dorothy E. Grice
Summary: This study evaluated the psychometric properties of the Swedish translation of the Obsessive-Compulsive Inventory-Revised (OCI-R) and explored the frequency, severity, and symptom dimensions of OCD comorbid with other psychiatric disorders. The results showed that the Swedish translation of OCI-R had good internal consistency and clear agreement with the six-factor model. Females had significantly higher total scores on the OCI-R compared to males. The most common psychiatric comorbidities with OCD were anxiety disorders and major depression.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Biology
Karina Wahl, Philipp Marcel Scholl, Silvan Wirth, Marcel Miche, Jeannine Haeni, Pia Schuelin, Roselind Lieb
Summary: Automatically detecting compulsive hand washing using wearable devices is an important step toward developing sensor-based assessments and interventions for obsessive-compulsive disorder (OCD). This study demonstrates that enacted compulsive hand washing can be distinguished from routine hand washing based on sensor data analysis, although specificity is low.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Psychiatry
Amanda R. Mahnke, Omer Linkovski, Kiara Timpano, Peter van Roessel, Catherine Sanchez, Andrea D. Varias, Pavithra Mukunda, Maria Filippou-Frye, Anthony Lombardi, Hannah Raila, Kelley Anderson, Thasveen Sandhu, Brianna Wright, Elizabeth A. McCarthy, Geronimo E. Garcia, Sepehr Asgari, Tori Qiu, Rebecca Bernert, Carolyn Rodriguez
Summary: Hoarding disorder (HD) is a mental disorder characterized by difficulty parting with possessions and impairing life functioning. Research shows that individuals with HD have poor sleep quality, higher levels of insomnia symptoms, and comorbid sleep disorders. Sleep may be a new target for treatment in improving outcomes for individuals with HD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Neurosciences
Benjamin Klugah-Brown, Chenyang Jiang, Elijah Agoalikum, Xinqi Zhou, Liye Zou, Qian Yu, Benjamin Becker, Bharat Biswal
Summary: This study aimed to identify robust brain structural markers for compulsivity across substance use disorders and obsessive-compulsive disorder. The findings indicate widespread GMV reductions in the left inferior frontal gyrus (IFG) in both disorders, suggesting a transdiagnostic brain structural marker. The IFG plays a key role in the cognitive control network and exhibits bidirectional interactions with the striatum.
HUMAN BRAIN MAPPING
(2021)
Article
Psychology, Clinical
Oskar Flygare, John Wallert, Long-Long Chen, Lorena Fernandez de la Cruz, Lina Lundstroem, David Mataix-Cols, Christian Rack, Erik Andersson
Summary: This study evaluated cutoffs for treatment response and remission in OCD using the self-rated Obsessive-Compulsive Inventory-Revised (OCI-R). The results showed that OCI-R is a simple and time-efficient way to determine treatment response and remission in OCD.
Article
Clinical Neurology
Zibin Yang, Shu Xiao, Ting Su, Jiayin Gong, Zhangzhang Qi, Guanmao Chen, Pan Chen, Guixian Tang, SiYing Fu, Hong Yan, Li Huang, Ying Wang
Summary: This meta-analysis study found abnormalities in both function and structure in the bilateral mPFC/ACC, insula, and IFG in patients with OCD. These findings contribute to a better understanding of the underlying pathophysiology of OCD and the development of more targeted and efficacious treatment and intervention strategies.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Psychology, Developmental
Omer Linkovski, Tyler M. Moore, Stirling T. Argabright, Monica E. Calkins, Ruben C. Gur, Raquel E. Gur, Ran Barzilay
Summary: Hoarding behavior is common in youth and is associated with poorer mental health and functioning, independent of obsessive-compulsive symptoms. Brief hoarding-behavior assessments in clinical settings may prove useful.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychiatry
Ana Beatriz Ravagnani Salto, Marcos L. Santoro, Marcelo Q. Hoexter, Andrea Parolin Jackowski, Pedro M. Pan, Maria Conceicao Rosario, Sintia Belangero, Pedro Gomes Alvarenga, Victoria Fogaca Doretto, Afonso Mazine Tiago Fumo, Marcelo C. Batistuzzo, Pedro Macul Ferreira de Barros, Kiara R. Timpano, Vanessa K. Ota, Luis Augusto Rohde, Euripedes Constantino Miguel, James F. Leckman, Andre Zugman
Summary: The study found a significant relationship between OCS and the symmetrized percent change (SPC) of the right thalamus volume in children, but there was no significant relationship between changes in thalamic volume SPC and OCD-PRS. These findings suggest the need for further research to confirm the results and further characterize the specific nature of OCS symptoms associated with thalamic volumes.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
Lizzie A. Wilson, Jessica Scarfo, Emra Suleyman, Imogen C. Rehm, Peter A. Baldwin
Summary: The current study confirmed the three-factor structure of the Saving Inventory - Revised (SI-R) and evaluated its construct and content validity using congeneric modelling. The results indicated that the SI-R is a valid, reliable, and well-fitting measure, although the difficulty discarding and clutter subscales needed to be covaried. The study concluded that the SI-R is an appropriate screening tool for hoarding severity, and suggested revising the item wording to improve content validity. Future research could explore the relationships between various hoarding-related constructs and the differential endorsement of SI-R subscales.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Jiaxiang Chen, Chong Tian, Qun Zhang, Hui Xiang, Rongpin Wang, Xiaofei Hu, Xianchun Zeng
Summary: This study used the Atlas-based method to detect volume changes in subregions of the basal ganglia in OCD patients, and compared the effects of different software on volumetric analysis. The results showed a significantly increased volume of bilateral lenticular nucleus in OCD patients compared to healthy controls. In addition, the Atlas-based method using Freesurfer software revealed a significantly increased volume of left globus pallidus, with the largest effect size of volumetric variation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Lin Song, Xiaodong Han, Yuanjing Li, Xiaolei Han, Mingqing Zhao, Chunyan Li, Pin Wang, Jiafeng Wang, Yi Dong, Lin Cong, Xiaojuan Han, Tingting Hou, Keke Liu, Yongxiang Wang, Chengxuan Qiu, Yifeng Du
Summary: The KIBRA rs17070145 C-allele is associated with a reduced likelihood of olfactory impairment among older adults, partly mediated through left thalamic gray matter volume.
Review
Clinical Neurology
Maral Melkonian, Sarah McDonald, Amelia Scott, Eyal Karin, Blake F. Dear, Bethany M. Wootton
Summary: Obsessive-compulsive disorder (OCD) is a chronic and unremitting condition with low rates of symptom improvement and spontaneous remission in the absence of treatment.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Basak Sahin, Yasir Safak, Kadir Ozdel
Summary: This study aimed to identify cognitive differences specific to symptom dimensions of OCD and investigate the relationship between these dimensions and cognitive features. The results showed that certain cognitive features were closely associated with specific symptom dimensions and could even predict these dimensions.
CURRENT PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Esengul Ekici, Mustafa Ugurlu, Fatih Yigman, Yasir Safak, Kadir Ozdel
Summary: Obsessive-Compulsive Disorder (OCD) is a heterogeneous disorder, and the dimensions of contamination, harm, unwanted thoughts, and symmetry may vary in each patient. This study found that cognitive and emotional factors and their relations varied depending on the OCD dimensions. Identifying cognitive and emotional factors related to these differences is of significance for therapeutic interventions.
CURRENT PSYCHOLOGY
(2023)
Article
Clinical Neurology
Junya Matsumoto, Kenichiro Miura, Masaki Fukunaga, Kiyotaka Nemoto, Daisuke Koshiyama, Naohiro Okada, Kentaro Morita, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Satsuki Ito, Naomi Hasegawa, Yoshiyuki Watanabe, Kiyoto Kasai, Ryota Hashimoto
Summary: Patients with schizophrenia may experience intelligence decline, and previous studies have suggested that gray matter structures and functional connectivity are more relevant to this decline than white matter microstructures.
CLINICAL EEG AND NEUROSCIENCE
(2023)
Article
Psychology, Multidisciplinary
Keisuke Kokubun, Yoshinori Yamakawa, Kiyotaka Nemoto
Summary: Motivation and empathy are fundamental elements of human interaction and are associated with organizational performance, academic achievements, and the human brain. This study used GM-BHQ to evaluate the association of motivation and empathy with the whole brain and found that GM-BHQ is most sensitive to motivation levels and moderately sensitive to self-monitoring and certain subscales of empathic concern.
CURRENT PSYCHOLOGY
(2023)
Article
Geriatrics & Gerontology
Haruhiko Midorikawa, Saori Ekoyama, Hirokazu Tachikawa, Miho Ota, Masashi Tamura, Takumi Takahashi, Aya Sekine, Masayuki Ide, Asaki Matsuzaki, Miyuki Nemoto, Kiyotaka Nemoto, Tetsuaki Arai
Summary: This study examined the differences in behavioral and psychological symptoms of dementia (BPSD) between individuals living at home and those in institutional settings. The results showed that sleep disturbances were more common in patients with AD living in institutions.
Article
Neurosciences
Ryotaro Ide, Miho Ota, Yasushi Hada, Takumi Takahashi, Masashi Tamura, Kiyotaka Nemoto, Tetsuaki Arai
Summary: This study investigated the relationship between balance function and the volume of the hippocampus and its subfields. The findings suggest a positive correlation between balance function and the volume of the whole hippocampus and specific subfields in healthy elderly individuals. Therefore, balance function may be associated with hippocampal volume.
Article
Clinical Neurology
Daisuke Fujikane, Kazutaka Ohi, Kiyotaka Nemoto, Yuma Horibe, Yunako Ogawa, Runa Taguchi, Riko Toba, Toshiki Shioiri
Summary: This study investigates the genetic factors associated with anxiety disorders and their impact on cortical alterations. The findings suggest a shared genetic etiology between anxiety disorders and structural features of the anterior cingulate gyrus, which may contribute to the pathogenesis of anxiety disorders. The study also highlights the potential usefulness of polygenic risk scores in reducing pathological heterogeneity among anxiety disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Hitoshi Iida, Tsuyoshi Okada, Kiyotaka Nemoto, Naomi Hasegawa, Shusuke Numata, Kazuyoshi Ogasawara, Kenichiro Miura, Junya Matsumoto, Hikaru Hori, Jun-ichi Iga, Kayo Ichihashi, Naoki Hashimoto, Hisashi Yamada, Kazutaka Ohi, Norio Yasui-Furukori, Kentaro Fukumoto, Takashi Tsuboi, Masahide Usami, Ryuji Furihata, Yoshikazu Takaesu, Akitoyo Hishimoto, Hiroyuki Muraoka, Eiichi Katsumoto, Tatsuya Nagasawa, Shinichiro Ochi, Hiroshi Komatsu, Saya Kikuchi, Masahiro Takeshima, Toshiaki Onitsuka, Shinichiro Tamai, Chika Kubota, Ken Inada, Koichiro Watanabe, Hiroaki Kawasaki, Ryota Hashimoto
Summary: The EGUIDE project was launched in 2016 to disseminate, educate, and validate psychiatric clinical practice guidelines. This study compared the effectiveness of web-based courses and face-to-face courses offered by the project. The results showed that web-based courses were rated as more satisfying than expected and there were no significant differences in satisfaction and clinical knowledge between the two formats. This suggests that web-based courses could be widely adopted alongside face-to-face courses after the COVID-19 pandemic.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2023)
Article
Health Care Sciences & Services
Kenta Yoshii, Daiki Kimura, Akihiro Kosugi, Kaoru Shinkawa, Toshiro Takase, Masatomo Kobayashi, Yasunori Yamada, Miyuki Nemoto, Ryohei Watanabe, Miho Ota, Shinji Higashi, Kiyotaka Nemoto, Tetsuaki Arai, Masafumi Nishimura
Summary: This study found that prosodic and acoustic features from conversations with a humanoid robot can be used to detect mild cognitive impairment (MCI) at an early stage with the same level of accuracy as the Mini-Mental State Examination (MMSE). This is significant for reducing the workload of elderly care.
JMIR FORMATIVE RESEARCH
(2023)
Article
Computer Science, Artificial Intelligence
Yasunori Yamada, Kaoru Shinkawa, Miyuki Nemoto, Kiyotaka Nemoto, Tetsuaki Arai
Summary: Speech analysis can be used as a screening tool for early detection of Alzheimer's disease (AD) and mild cognitive impairment (MCI). Automatic speech analysis, including speech recognition, can accurately classify AD, MCI, and cognitively normal (CN) groups with an accuracy of 78.6%.
COMPUTER SPEECH AND LANGUAGE
(2023)
Article
Medicine, General & Internal
Masatoshi Yamashita, Kuriko Kagitani-Shimono, Yoshiyuki Hirano, Sayo Hamatani, Shota Nishitani, Akiko Yao, Sawa Kurata, Hirotaka Kosaka, Minyoung Jung, Tokiko Yoshida, Tsuyoshi Sasaki, Koji Matsumoto, Yoko Kato, Mariko Nakanishi, Masaya Tachibana, Ikuko Mohri, Kenji J. Tsuchiya, Tetsuya Tsujikawa, Hidehiko Okazawa, Eiji Shimizu, Masako Taniike, Akemi Tomoda, Yoshifumi Mizuno
Summary: This study aims to correct site differences in MRI scanners and clarify brain structure and network characteristics of children with ADHD and ASD using large samples collected in a multi-centre collaboration. Additionally, the relationship between these characteristics and genetic, epigenetic, biochemical markers, and behavioral and psychological measures will be investigated.
Article
Psychiatry
Haruhiko Midorikawa, Hirokazu Tachikawa, Natsuho Kushibiki, Keiko Wataya, Sho Takahashi, Yuki Shiratori, Kiyotaka Nemoto, Shinichiro Sasahara, Shotaro Doki, Daisuke Hori, Ichiyo Matsuzaki, Testuaki Arai, Kunihiro Yamagata
Summary: This study aimed to investigate the relationship between fear of COVID-19, resilience, and psychological distress among healthcare workers treating COVID-19 patients. The findings revealed that occupation, fear of COVID-19, and resilience were important factors influencing psychological distress. Therefore, creating consultation services for healthcare workers to discuss their concerns and strengthening their resilience are crucial for providing mental healthcare during a pandemic.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Fumiyo Oshima, William Mandy, Mikuko Seto, Minako Hongo, Aki Tsuchiyagaito, Yoshiyuki Hirano, Chihiro Sutoh, Siqing Guan, Yusuke Nitta, Yoshihito Ozawa, Yohei Kawasaki, Toshiyuki Ohtani, Jiro Masuya, Noriko Takahashi, Noriyuki Sato, Shizuka Nakamura, Akiko Nakagawa, Eiji Shimizu
Summary: The study found that the ACAT program has a positive impact on increasing understanding of autistic attributes among autistic adolescents and their parents/guardians, reducing treatment stigma, and improving mental health for autistic adolescents. However, it does not significantly affect the mental health and adaptive skills of parents/guardians.
Article
Biochemistry & Molecular Biology
Junya Matsumoto, Masaki Fukunaga, Kenichiro Miura, Kiyotaka Nemoto, Naohiro Okada, Naoki Hashimoto, Kentaro Morita, Daisuke Koshiyama, Kazutaka Ohi, Tsutomu Takahashi, Michihiko Koeda, Hidenaga Yamamori, Michiko Fujimoto, Yuka Yasuda, Satsuki Ito, Ryuichi Yamazaki, Naomi Hasegawa, Hisashi Narita, Satoshi Yokoyama, Ryo Mishima, Jun Miyata, Yuko Kobayashi, Daiki Sasabayashi, Kenichiro Harada, Maeri Yamamoto, Yoji Hirano, Takashi Itahashi, Masahito Nakataki, Ryu-ichiro Hashimoto, Khin K. Tha, Shinsuke Koike, Toshio Matsubara, Go Okada, Reiji Yoshimura, Osamu Abe, Theo G. M. van Erp, Jessica A. Turner, Neda Jahanshad, Paul M. Thompson, Toshiaki Onitsuka, Yoshiyuki Watanabe, Koji Matsuo, Hidenori Yamasue, Yasumasa Okamoto, Michio Suzuki, Norio Ozaki, Kiyoto Kasai, Ryota Hashimoto
Summary: According to operational diagnostic criteria, psychiatric disorders such as schizophrenia, bipolar disorder, major depressive disorder, and autism spectrum disorder are classified based on symptoms. This study explored the similarities and differences in cortical structural neuroimaging features among these disorders. The findings revealed common patterns of cortical thickness and surface area alterations among schizophrenia, bipolar disorder, and major depressive disorder.
MOLECULAR PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Naohiro Okada, Masaki Fukunaga, Kenichiro Miura, Kiyotaka Nemoto, Junya Matsumoto, Naoki Hashimoto, Masahiro Kiyota, Kentaro Morita, Daisuke Koshiyama, Kazutaka Ohi, Tsutomu Takahashi, Michihiko Koeda, Hidenaga Yamamori, Michiko Fujimoto, Yuka Yasuda, Naomi Hasegawa, Hisashi Narita, Satoshi Yokoyama, Ryo Mishima, Takahiko Kawashima, Yuko Kobayashi, Daiki Sasabayashi, Kenichiro Harada, Maeri Yamamoto, Yoji Hirano, Takashi Itahashi, Masahito Nakataki, Ryu-ichiro Hashimoto, Khin K. Tha, Shinsuke Koike, Toshio Matsubara, Go Okada, Theo G. M. van Erp, Neda Jahanshad, Reiji Yoshimura, Osamu Abe, Toshiaki Onitsuka, Yoshiyuki Watanabe, Koji Matsuo, Hidenori Yamasue, Yasumasa Okamoto, Michio Suzuki, Jessica A. Turner, Paul M. Thompson, Norio Ozaki, Kiyoto Kasai, Ryota Hashimoto
Summary: This article discusses the difficulties in differential diagnosis in practical psychiatric settings and the prospect of creating a novel diagnostic system using objective biomarkers. Neuroimaging studies have shown that subcortical brain structures are associated with various psycho-behavioral functions, but there are currently no neuroimaging data-driven clinical criteria that can overcome the limitations of the current diagnostic system in reflecting cognitive/social functioning. The authors conducted a large-scale study and found volumetric and lateralization alterations in several psychiatric disorders, which were associated with cognitive/social functioning.
MOLECULAR PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Tadashi Shiohama, Norihide Maikusa, Masahiro Kawaguchi, Jun Natsume, Yoshiyuki Hirano, Keito Saito, Jun-ichi Takanashi, Jacob Levman, Emi Takahashi, Koji Matsumoto, Hajime Yokota, Shinya Hattori, Keita Tsujimura, Daisuke Sawada, Tomoko Uchida, Tomozumi Takatani, Katsunori Fujii, Shinji Naganawa, Noriko Sato, Hiromichi Hamada, Andor W. J. M. Glaudemans
Summary: This study aims to provide normal reference values of global and regional brain volumes for children and adolescents of different sexes and age groups across multiple institutions. MRI examinations of 846 neurotypical participants were collected, and regional brain volumes were measured and analyzed using the CIVET 2.1.0. pipeline and ComBat-GAM harmonization. The results of this study can be used to evaluate the brain morphology of individuals in a clinical setting and investigate brain morphology in ultra-rare diseases.
Article
Geriatrics & Gerontology
Miho Ota, Kiyotaka Nemoto, Miyuki Nemoto, Yuriko Numata, Ayako Kitabatake, Yasunori Yamada, Kaoru Shinkawa, Masatomo Kobayashi, Tetsuaki Arai
Summary: This study uses magnetic resonance imaging to investigate the alterations in cerebral networks in the early stages of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). The results suggest that changes in the degree of connectivity in specific brain regions may serve as potential biomarkers for the early detection of AD and DLB.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2023)
