Article
Endocrinology & Metabolism
Hui Huang, Jie Liu, Xiaolei Wang, Shaoyan Liu
Summary: This study examines the outcomes of active surveillance for nonsuspicious contralateral nodules in patients with papillary thyroid carcinoma. The study found that active surveillance is safe for low-risk and selected intermediate-risk patients, and that multifocality and ATA intermediate-risk are predictors for recurrence.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Rosie Sutherland, Venessa Tsang, Roderick J. Clifton-Bligh, Matti L. Gild
Summary: The incidence of papillary thyroid carcinoma is increasing, with a focus on overdiagnosis and disease progression. While most cases follow a chronic disease course, some show more aggressive features. Current guidelines recommend against routine biopsy for nodules <= 10 mm, and active surveillance is recommended for low-risk PTMC.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Wu Ding, Guodong Ruan, Yingli Lin, Jianming Zhu, Zhian Li, Dengfeng Ye
Summary: This study aims to establish appropriate management strategies for low-risk papillary thyroid carcinoma (PTC) patients by comparing outcomes of active surveillance (AS) in different tumor sizes and lymph node metastasis status. The study provides valuable insights for the effective management of such patients, addressing the issues and challenges associated with AS in practical clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Wen Liu, Xuejing Yan, Ruochuan Cheng
Summary: Low risk papillary thyroid microcarcinoma (PTMC) has become a clinical and social issue due to exponential increases in incidences, leading to the increasing popularity of an active surveillance (AS) approach worldwide. However, Chinese thyroid surgeons lag behind in knowledge of AS practices, and a management approach based on the Chinese population should be developed to reduce disease progression risk. It is important for surgeons to understand patient willingness, impact on the medical billing system, and doctor enthusiasm for AS implementation in China.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Endocrinology & Metabolism
Meihua Jin, Hye In Kim, Jeonghoon Ha, Min Ji Jeon, Won Gu Kim, Dong-Jun Lim, Tae Yong Kim, Jae Hoon Chung, Young Kee Shong, Tae Hyuk Kim, Won Bae Kim
Summary: The study found that TVDT <5 years is a crucial predictor of disease progression in PTMC during active surveillance, indicating new LN metastasis development and tumor enlargement. This early determination of TVDT could assist in tailoring follow-up intensity and determining the need for early surgical intervention.
Article
Endocrinology & Metabolism
Samuel M. M. Cohen, Julia E. E. Noel, Michael Baroody, Lisa A. A. Orloff
Summary: According to a retrospective chart review, preoperative ultrasound can predict regional metastases in papillary thyroid microcarcinoma to some extent. The size of the tumor, distance to the thyroid capsule or trachea, tumor contour, and presence of autoimmune thyroiditis are not correlated with regional metastasis. Nodules in the superior or midpole are associated with central or lateral neck metastases, while nodules in the isthmus or inferior pole are only associated with central neck metastases. Therefore, active surveillance can be considered for patients with papillary thyroid microcarcinoma adjacent to the thyroid capsule.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Eleanor White, Bridget Abbott, Geoffrey Schembri, Anthony Glover, Roderick Clifton-Bligh, Matti L. Gild
Summary: This study developed an evidence-based web delivered decision support tool to assist clinicians in identifying patients appropriate for active surveillance in papillary thyroid cancer. Analysis of a retrospective database showed that approximately 48% of patients who met the criteria could be suitable for active surveillance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jing He, Mingxia Zhou, Jie Yin, Junhu Wan, Jie Chu, Jinlin Jia, Jinxiu Sheng, Chang Wang, Huiqing Yin, Fucheng He
Summary: The RNA modification N6-methyladenosine (m6A) plays a crucial role in papillary thyroid carcinoma (PTC) by regulating the tumor-suppressive effects of METTL3 on c-Rel and RelA. Additionally, METTL3 disruption leads to IL-8 secretion and altered recruitment of tumor-associated neutrophils (TANs), affecting tumor growth and metastasis.
Article
Endocrinology & Metabolism
Iwao Sugitani
Summary: The incidence of thyroid carcinoma has been increasing rapidly worldwide, mainly due to the incidental detection of small papillary thyroid carcinomas through high-resolution imaging techniques. However, the mortality rates of thyroid carcinoma have not changed, suggesting overdiagnosis and overtreatment. Active surveillance has been introduced as an alternative to immediate surgery, with strict eligibility criteria and close monitoring for cancer progression. Adequate shared decision-making is crucial, and surgery is recommended for clinically apparent metastasis or invasion.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Oncology
Jinzhe Bi, Peng-fei Lyu, Yu Wang, Hao Zhang
Summary: This study aimed to investigate whether surgery can achieve significant survival benefits in patients with larger tumor diameter of papillary thyroid carcinoma (PTC), in order to evaluate the feasibility of expanding the threshold for active surveillance. The results showed that as the tumor diameter increases, the risk of death without surgical treatment gradually increases, but there may be a threshold. Within this range, a non-surgical approach may be a potentially viable management strategy. However, beyond this range, surgery may be more beneficial for patient survival.
FRONTIERS IN ONCOLOGY
(2023)
Review
Otorhinolaryngology
Alvaro Sanabria, Pilar Pinillos, Renan B. Lira, Jatin P. Shah, Ralph P. Tufano, Mark E. Zafereo, Iain J. Nixon, Gregory W. Randolph, Ricard Simo, Vincent Vander Poorten, Alessandra Rinaldo, Jesus E. Medina, Avi Khafif, Peter Angelos, Antti A. Makitie, Ashok R. Shaha, Juan P. Rodrigo, Dana M. Hartl, Luiz P. Kowalski, Alfio Ferlito
Summary: The study reviewed literature on the indications for management selection for low-risk thyroid carcinomas, finding significant heterogeneity in inclusion and exclusion criteria. The most commonly reported inclusion criteria were nodule diameter and histopathological confirmation of tumor type, while lymph node metastasis and extra-thyroidal extension were common exclusions. Alternative therapeutic approaches in low-risk carcinomas can be considered cautiously, with open thyroidectomy remaining the standard treatment.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Bulin Du, Shu Wang, Yi Liu, Yaming Li, Xuena Li
Summary: A 58-year-old man with a history of papillary thyroid cancer (PTC) presented with blood in the sputum. FDG PET/CT imaging revealed lesions in the posterior hypopharyngeal wall and left parapharyngeal space. Surgical pathology confirmed metastasis of PTC. Hypopharyngeal metastasis of PTC is rare and must be differentiated from metastatic hypopharyngeal carcinoma.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Endocrinology & Metabolism
Ivona Loncar, Sam P. J. van Dijk, Madelon J. H. Metman, Jia Feng Lin, Schelto Kruijff, Robin P. Peeters, Anton F. Engelsman, Tessa M. van Ginhoven
Summary: Based on data from the Netherlands between 2005 and 2015, the study found that restrictive diagnostic workup of thyroid nodules leads to limited candidates for active surveillance (AS) and a higher incidence of lymph node metastases.
Article
Surgery
Anna C. Beck, Anand Rajan, Shannon Landers, Sarah Kelley, Andrew M. Bellizzi, Geeta Lal, Sonia L. Sugg, James R. Howe, Carlos H. Chan, Ronald J. Weigel
Summary: The study showed that the tall cell variant of papillary thyroid carcinoma has increased expression of cancer stem cell markers compared to classic papillary thyroid carcinoma. A gene signature similar to the tall cell variant identified a subtype of classic papillary thyroid carcinoma with worse recurrence-free survival.
Article
Endocrinology & Metabolism
Eun Kyung Lee, Jae Hoon Moon, Yul Hwangbo, Chang Hwan Ryu, Sun Wook Cho, June Young Choi, Eun-Jae Chung, Woo-Jin Jeong, Yuh-Seog Jung, Junsun Ryu, Su-jin Kim, Min Joo Kim, Yeo Koon Kim, Chang Yoon Lee, Ji Ye Lee, Hyeong Won Yu, Jeong Hun Hah, Kyu Eun Lee, You Jin Lee, Sue K. Park, Do Joon Park, Ji-hoon Kim, Young Joo Park
Summary: This multicenter prospective cohort study conducted in Korea suggests that the risk of progression during active surveillance (AS) for low-risk papillary thyroid microcarcinoma (PTMC) is low in the Korean population, but slightly higher than in other populations. Younger age, male sex, and larger tumor size were identified as independent significant factors for disease progression during AS.
Article
Otorhinolaryngology
Catherine F. Sinclair, Erin Buczek, Elizabeth Cottril, Peter Angelos, Marcin Barczynski, Allen Ho, Viktor Makarin, Thomas Musholt, Joseph Scharpf, Rick Schneider, Brendan C. Stack, Maria J. Tellez, Neil Tolley, Gayle Woodson, Che Wei Wu, Greg Randolph
Summary: This paper aims to define categories of benefit for I-IONM/C-IONM and to clarify and standardize their reporting outcomes. I-IONM can assist in diagnosis, classification, and prevention of nerve injury, while C-IONM provides real-time information on nerve functional integrity.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Biochemical Research Methods
Allen S. Ho, Aaron Robinson, Wonwoo Shon, Anna Laury, Koen Raedschelders, Vidya Venkatraman, Ronald Holewinski, Yi Zhang, Stephen L. Shiao, Michelle M. Chen, Jon Mallen-St. Clair, De-Chen Lin, Zachary S. Zumsteg, Jennifer E. Van Eyk
Summary: This study investigated protein differential expression in HPV(+) OPSCC samples and found that functional pathways involved in cell death, apoptosis, WNT signaling, and Rho GTPase signaling play important roles in disease recurrence. Downregulation of certain molecular targets is associated with recurrence and may serve as markers for high-risk disease. Immunohistochemistry staining validated some of the mass spectrometry findings.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Endocrinology & Metabolism
Gregory W. Randolph, Julie Ann Sosa, Yangyang Hao, Trevor E. Angell, David C. Shonka, Virginia A. LiVolsi, Paul W. Ladenson, Thomas C. Blevins, Quan-Yang Duh, Ronald Ghossein, Mack Harrell, Kepal Narendra Patel, Michael H. Shanik, S. Thomas Traweek, P. Sean Walsh, Michael W. Yeh, Amr H. Abdelhamid Ahmed, Allen S. Ho, Richard J. Wong, Joshua P. Klopper, Jing Huang, Giulia C. Kennedy, Richard T. Kloos, Peter M. Sadow
Summary: In this study, a RNA-sequencing MTC classifier was developed that accurately identified MTC from preoperative thyroid nodule FNAB specimens. This identification may facilitate an MTC-specific preoperative evaluation and resulting treatment.
Review
Endocrinology & Metabolism
Catherine F. Sinclair, Amanda J. Bastien, Allen S. Ho
Summary: Radiofrequency ablation (RFA) is safe and effective for addressing compressive or cosmetic issues caused by benign thyroid nodules. Multiple staged RFA procedures may be necessary in some cases. Consensus guidelines have emerged to define appropriate patient candidates.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2022)
Article
Medicine, Research & Experimental
Eric M. Anderson, Michael Luu, Diana J. Lu, Eric M. Chung, Christopher Gay, Kevin S. Scher, Alain C. Mita, Jon Mallen-St Clair, Allen S. Ho, Zachary S. Zumsteg
Summary: The study confirms that lymphovascular invasion and histologic grade are the strongest predictors of neck lymph node metastasis in cN0 patients with pharynx and larynx cancer. Neck dissection is still necessary for cN0 patients to identify the risk of lymph node metastasis even in the modern era.
Editorial Material
Endocrinology & Metabolism
Allen S. Ho, Amanda J. Bastien, Wendy L. Sacks
Article
Oncology
Allen S. Ho, Sungjin Kim, Cynthia Zalt, Michelle L. Melany, Irene E. Chen, Joan Vasquez, Jon Mallen-St Clair, Michelle M. Chen, Missael Vasquez, Xuemo Fan, Welmoed K. van Deen, Robert W. Haile, Timothy J. Daskivich, Zachary S. Zumsteg, Glenn D. Braunstein, Wendy L. Sacks
Summary: Unlike prostate cancer, active surveillance for thyroid cancer has not been widely adopted. This study suggests that expanded size/growth parameters may be feasible for low-risk thyroid cancer patients, and patient anxiety has an impact on the approach.
Letter
Medicine, Research & Experimental
Eric Anderson, Michael Luu, Allen S. Ho, Zachary S. Zumsteg
Article
Otorhinolaryngology
Allen S. Ho, Michael Luu, Bonnie L. Balzer, Katri Aro, Julie K. Jang, Alain C. Mita, Kevin S. Scher, Jon Mallen-St. Clair, Missael Vasquez, Amanda J. Bastien, Joel B. Epstein, De-Chen Lin, Michelle M. Chen, Zachary S. Zumsteg
Summary: This study investigated the impact of histologic variants and grade on the prognosis of salivary cancer. The results showed that histologic variants had different mortality risks, but these differences were diminished in multivariable analysis. In contrast, worsening grade was strongly associated with deteriorating survival. Integrating grade into stage can improve the predictive ability of the current staging system.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Letter
Oncology
Allen S. S. Ho, Wendy L. Sacks, Zachary S. Zumsteg
Letter
Otorhinolaryngology
Allen S. Ho, Michael Luu, Bonnie L. Balzer, Zachary S. Zumsteg
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2023)
Article
Oncology
Eric M. Anderson, Michael Luu, Eric M. Chung, Christopher Gay, Jon Mallen-St Clair, Allen S. Ho, Zachary S. Zumsteg
Summary: Elective lymph node dissection (ELND) is commonly performed for early-stage oral cavity squamous cell carcinomas (OCSCC) with clinically negative necks. However, the validity of depth of invasion (DOI) as a predictor of lymph node positivity (pN+) varies in different OC sites. This study found that lymphovascular invasion and histologic grade were strong independent predictors of pN+ in cN0 OCSCC, while DOI was not associated with pN+ in the overall OCSCC population, but showed some predictive value in the oral tongue subset.
Article
Otorhinolaryngology
Amanda J. Bastien, Allen S. Ho
OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA
(2024)
Article
Biotechnology & Applied Microbiology
Yueyuan Zheng, Benjamin Ziman, Allen S. Ho, Uttam K. Sinha, Li-Yan Xu, En-Min Li, H. Phillip Koeffler, Benjamin P. Berman, De-Chen Lin
Summary: Researchers analyzed whole-genome bisulfite sequencing data on 45 esophageal tumor and nonmalignant samples from both subtypes, revealing distinct DNA methylation features and partially methylated domains (PMDs) associated with transcription repression, chromatin compartments, and somatic mutation rate. They also found that these features co-occur in other cancers originating from the same cell types.
Letter
Oncology
Allen S. Ho, Wendy L. Sacks, Zachary S. Zumsteg
