Review
Biochemistry & Molecular Biology
Zhenzhen Qi, Zheng Yan, Guohongfang Tan, Subhas C. Kundu, Shenzhou Lu
Summary: Research on smart responsive polymer microneedles aims to achieve local accurate drug release, which have advantages such as painless administration, good biocompatibility, and ease of self-administration, and hold significant research implications in transdermal drug administration.
Review
Pharmacology & Pharmacy
Merima Sirbubalo, Amina Tucak, Kenan Muhamedagic, Lamija Hindija, Ognjenka Rahic, Jasmina Hadziabdic, Ahmet Cekic, Derzija Begic-Hajdarevic, Maida Cohodar Husic, Almir Dervisevic, Edina Vranic
Summary: Microneedles are micropuncture devices that penetrate the skin painlessly and facilitate transdermal drug delivery. Traditional manufacturing methods for MNs are time-consuming and expensive, while 3D printing technology offers a revolutionary way to produce personalized dosage forms and patient-specific medical devices.
Article
Chemistry, Multidisciplinary
Adam C. Farsheed, Adam J. Thomas, Brett H. Pogostin, Jeffrey D. Hartgerink
Summary: 3D printing is extensively utilized in biomedical research, particularly for creating structures that mimic the mechanical properties of biological tissues. However, there is a challenge in 3D printing hydrogels due to the difficulty in patterning soft materials in three dimensions. To address this, novel hydrogels with desirable biological properties are needed as 3D printable inks.
ADVANCED MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Sophia N. Economidou, Dennis Douroumis
Summary: This review identified key progress points in using 3D printing to manufacture microneedles over the past 3 years, particularly focusing on advances in photopolymerization and extrusion-based 3D printing. The study highlighted that printing resolution and material properties are the two critical parameters that significantly influence the outcome of microneedle printing endeavors. Finally, the authors attempted to estimate the impact of 3D printing on the transdermal drug delivery market.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Medicine, Research & Experimental
Ziyan Chen, Huayi Wu, Shuang Zhao, Xiang Chen, Tianhong Wei, Hanmin Peng, Zeyu Chen
Summary: Microneedles are an innovative minimally invasive method for drug delivery, and researchers have proposed an integrated 3D-printed ultrasonic microneedle array device that enables fast and controllable drug delivery. The device significantly enhances drug delivery efficiency while reducing insertion force and tissue damage.
MOLECULAR PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Michael Olowe, Santosh Kumar Parupelli, Salil Desai
Summary: This article reviews different 3D printing technologies with the potential to revolutionize the manufacturing of microneedles, highlighting their applications in various fields and the challenges they face. It also discusses FDA regulatory guidelines and the implementation of futuristic technologies for 3D printed microneedles, such as artificial intelligence algorithms and 4D printing capabilities.
Article
Biochemistry & Molecular Biology
Nathaniel Wright, Tim Wu, Yadong Wang
Summary: In this study, a three-layer microneedle for controlled release of three different molecules is designed. The microneedles, efficiently generated through micromolding, have good mechanical integrity and effectively penetrate the skin. The three layers in the microneedles release the cargo in a three-phase manner.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Sangmin Choo, SungGiu Jin, JaeHwan Jung
Summary: Microneedles with high resolution and high dimensionality were successfully fabricated using SLA 3D printing by optimizing the printing conditions. This technology can be applied in the manufacturing of drug delivery tools and various microstructures.
Article
Pharmacology & Pharmacy
Vivek Yadav, Peeyush Kumar Sharma, Upadhyayula Suryanarayana Murty, Narayan H. Mohan, Rajendran Thomas, Santosha Kumar Dwivedy, Subham Banerjee
Summary: A 3D printed assembly of hollow microneedles, designed and manufactured using stereolithography technology, was used for transdermal delivery of high molecular weight antibiotics. The microneedles were designed with sub-apical holes for improved mechanical strength, and were characterized for quality and uniformity. Ex vivo and in vivo experiments confirmed the efficient penetration and desired bioavailability of the antibiotic.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Leonard Siebert, Eder Luna-Ceron, Luis Enrique Garcia-Rivera, Junsung Oh, JunHwee Jang, Diego A. Rosas-Gomez, Mitzi D. Perez-Gomez, Gregor Maschkowitz, Helmut Fickenscher, Daniela Oceguera-Cuevas, Carmen G. Holguin-Leon, Batzaya Byambaa, Mohammad A. Hussain, Eduardo Enciso-Martinez, Minsung Cho, Yuhan Lee, Nebras Sobahi, Anwarul Hasan, Dennis P. Orgill, Yogendra Kumar Mishra, Rainer Adelung, Eunjung Lee, Su Ryon Shin
Summary: Advanced wound scaffolds integrating active substances have recently gained attention for potential treatment of chronic wounds. The development of a 3D printed hydrogel patch encapsulating VEGF and decorated with t-ZnO microparticles allows for multiple functions to be combined and smart release achieved through chemical modification and photoactivation. This method also enhances the elastic modulus and degradation behavior of the composite hydrogels while maintaining antibacterial properties.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Polymer Science
Carlos B. P. Oliveira, Valeria Gomes, Paula M. T. Ferreira, Jose A. Martins, Peter J. Jervis
Summary: This review highlights the latest developments in supramolecular peptide-based hydrogels for drug delivery, focusing on peptide self-assembly, drug release, mechanical properties, functionalization, bioadhesive properties, and drug delivery enhancement strategies.
Article
Multidisciplinary Sciences
Cassie Caudill, Jillian L. Perry, Kimon Iliadis, Addis T. Tessema, Brian J. Lee, Beverly S. Mecham, Shaomin Tian, Joseph M. DeSimone
Summary: Faceted microneedles produced with CLIP 3D printing technology show improved surface coating of vaccine components, enhanced cargo retention in skin, immune cell activation, and humoral immune response, as well as eliciting T cell responses in animal models. This platform offers a promising approach for noninvasive, self-applicable vaccination.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Pharmacology & Pharmacy
Qingliang Yang, Weizhen Zhong, Lei Xu, Huijie Li, Qinying Yan, Yuanbin She, Gensheng Yang
Summary: Microneedles as a novel transdermal drug delivery system have gained extensive attention for their improved patient compliance and self-administration compared to traditional administration methods. Recent studies on utilizing 3D printing to fabricate transdermal drug delivery systems show promising potential for versatile printing methodologies and different formulation strategies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Biotechnology & Applied Microbiology
Yanghui Xing, Buhui Zeng, Wang Yang
Summary: Light responsive hydrogels are an important drug delivery system that can accurately control drug release by incorporating photosensitive moieties into their structures. Advances in photosensitizers have enabled the use of different light sources, and hydrogels with photosensitizers have improved therapeutic effects. Existing light responsive drug delivery systems have been applied in chemotherapy, immunotherapy, photodynamic therapy, gene therapy, and other fields.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Patricia Monks, Jacek K. Wychowaniec, Eoin McKiernan, Shane Clerkin, John Crean, Brian J. Rodriguez, Emmanuel G. Reynaud, Andreas Heise, Dermot F. Brougham
Summary: This study demonstrates the use of multifunctional nanocomposites based on magnetic hydrogels for heat generation under alternating magnetic field irradiation, as well as the manipulation of spatial heat distribution through 3D printing. The research discusses the dependence of heat induction on various factors, such as particle concentration, gel volume, exposed surface area, and environmental conditions, and explores the potential applications in responsive scaffold remodeling and cargo release for regenerative medicine.
