Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 62, Issue -, Pages 17-25Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2019.07.014
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- Marie Sklodowska-Curie Actions Innovative Training [Network675407]
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In the liver, the tight spatiotemporal regulation of Wnt/beta-catenin signaling is required to establish and maintain a metabolic form of tissue polarity termed zonation. In this review, we discuss the latest technologies applied in the study of liver zonation and provide a summary of the Wnt ligand and receptor expression patterns in the hepatic lobule. We further discuss the mechanisms, by which Wnt instructive cues might be spatially confined and propagated along the central vein-portal triad axis.
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