Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 62, Issue -, Pages 150-158Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2019.11.001
Keywords
Fungi; Polarized growth; Membrane traffic; Acidic phospholipids; GTPases; Cell shape
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Funding
- Centre national de la recherche scientifique (CNRS)
- Institut national de la santeet de la recherche medicale (INSERM)
- Universite Cote d'Azur (UCA)
- European Union Horizon 2020 Marie Sklodowska-Curie Research and Innovation Programme [MSCA-ITN-2015-675407]
- ANR [ANR-15-IDEX-01, ANR-11-LABX-002801, ANR-16-CE13-0010-01]
- Agence Nationale de la Recherche (ANR) [ANR-16-CE13-0010] Funding Source: Agence Nationale de la Recherche (ANR)
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As the majority of fungi are nonmotile, polarized growth in response to an external signal enables them to search for nutrients and mating partners, and hence is crucial for survival and proliferation. Although the mechanisms underlying polarization in response to external signals has commonalities with polarization during mitotic division, during budding, and fission growth, the importance of diverse feedback loops regulating external signal-mediated polarized growth is likely to be distinct and uniquely adapted to a dynamic environment. Here, we highlight recent advances in our understanding of the mechanisms that are crucial for polarity in response to external signals in fungi, with particular focus on the roles of membrane traffic, small GTPases, and lipids, as well as the interplay between cell shape and cell growth.
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