Article
Oncology
Ye Shen, Jason S. Eng, Flordeliza Fajardo, Lingming Liang, Cong Li, Patrick Collins, Donato Tedesco, Olivier Nolan-Stevaux
Summary: This study reveals that genetic alterations in cancer cells have a significant impact on the antitumor activity of bispecific T-cell engagers (BiTEs). The T-cell costimulation pathway and the apoptosis pathway are identified as key modifiers of BiTE activity. Loss of genes such as CD58, CD80/CD86, CFLAR, BCL2L1, and BID can alter the responsiveness to BiTE therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Natalia Nosalova, Alexandra Keselakova, Martin Kello, Miroslava Martinkova, Dominika Fabianova, Martina Bago Pilatova
Summary: Despite the decreasing trend in mortality from colorectal cancer, this study focused on the antiproliferative and pro-apoptotic effects of a compound on colon cancer cells. The compound was found to have concentration-dependent cytotoxic and antiproliferative effects, inducing both intrinsic and extrinsic apoptotic pathways and inhibiting cell migration. These findings suggest the potential of this compound as a future treatment for colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Anna-Christina Rambow, Insa Aschenbach, Sofie Hagelund, Doaa Tawfik, Jan-Paul Gundlach, Sebastian Weisse, Nicolai Maass, Anna Trauzold
Summary: Binding of TRAIL to its death domain-containing receptors TRAIL-R1 and TRAIL-R2 can induce cell death and/or pro-inflammatory signaling. The importance of TRAIL and TRAIL-R1/R2 in tumor immune surveillance and cancer biology has meanwhile been well documented. TRAIL also binds to TRAIL-R3 and TRAIL-R4, which have regulatory functions in apoptotic and non-apoptotic signaling pathways. Knockdown of TRAIL-R4 affects the activation of apoptotic and non-apoptotic pathways in cancer cells, showing opposing effects on cell death and clonogenic survival. TRAIL-R4 also regulates the expression of anti-apoptotic proteins and affects the activity of AKT, ERK, p38 and NF-kappa B. This study provides evidence for the important role of endogenous TRAIL-R4 in cancer cells and improves the understanding of the complex TRAIL/TRAIL-R system in humans.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Ryan R. Kowash, Esra A. Akbay
Summary: The adenosine pathway, particularly CD73, is a promising target for cancer immunotherapy, especially in non-small cell lung cancer (NSCLC) where CD73 expression is high. Combining immune checkpoint blockade (ICB) therapies with adenosine pathway inhibitors shows potential for the treatment of lung cancer. Clinical trials exploring the activation of both T and NK cells are in early stages. Understanding the role of CD73 in immune modulation and its intrinsic properties in tumor cells is important for future therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Zhou Fang, Haekyung Lee, Junying Liu, Karen A. Wong, Lewis M. Brown, Xiang Li, Alus M. Xiaoli, Fajun Yang, Ming Zhang
Summary: This study found that C3 can reduce myocardial apoptosis by interacting with the intrinsic apoptotic pathway in cardiomyocytes.
Article
Astronomy & Astrophysics
Eileen Sophie Giesel, Basundhara Ghosh, Bjoern Malte Schaefer
Summary: This paper generalizes the linear model of galaxy intrinsic alignments to include intrinsic flexions. The model links the third moments of brightness distribution with distortions of elliptical galaxies caused by third derivatives of the gravitational potential or gradients of the tidal gravitational fields. The study finds that the spectra of intrinsic flexions are typically an order of magnitude smaller than lensing flexions and shows a negative cross-correlation between intrinsic and extrinsic gravitational flexions. The observability of intrinsic and extrinsic flexions is also quantified using the Fisher formalism, with the findings suggesting that intrinsic flexions are challenging to measure and may only be detectable under highly optimistic conditions.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Fernanda Rodrigues Nascimento, Jefferson Viktor de Paula Barros Baeta, Andressa Antunes Prado de Franca, Maria Aparecida Braga Rocha E Oliveira, Virginia Ramos Pizziolo, Anesia Aparecida dos Santos, Tiago Antonio de Oliveira Mendes, Gaspar Diaz-Munoz, Marisa Alves Nogueira Diaz
Summary: DPBP has been found to have high in vitro antineoplastic activity against melanoma cells, inducing tumor cell death through apoptosis pathways with high selectivity. Treatment with DPBP reduced tumor volume and did not cause hepatomegaly or nephrotoxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Oncology
Regis Brion, Malika Gantier, Kevin Biteau, Julien Taurelle, Benedicte Brounais-Le Royer, Franck Verrecchia, Francoise Redini, Romain Guiho
Summary: Osteosarcoma and Ewing sarcoma are the most common malignant primary bone tumors in children. Triggering the TRAIL pro-apoptotic pathway shows promise in treating these tumors, but resistance mechanisms have limited its effectiveness. This study used human cell lines and xenograft models to investigate the differences in signaling pathways between TRAIL-sensitive and TRAIL-resistant cells, and proposed two strategies to overcome resistance.
Article
Neurosciences
Bryony L. Winters, Benjamin K. Lau, Christopher W. Vaughan
Summary: The midbrain periaqueductal gray (PAG) plays a central role in pain modulation. Opioids and cannabinoids activate descending pathways by relieving GABAergic inhibition of PAG neurons and suppressing GABAergic inputs from the amygdala. Opioids inhibit both intrinsic and extrinsic GABAergic inputs onto all PAG neurons, while cannabinoids selectively inhibit the direct GABAergic input from the amygdala onto PAG projection neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Zhengmeng Xu, Kai Zhang, J. Li
Summary: The study reveals that both intrinsic damping and two-magnon scattering make significant contributions to the total Gilbert damping in epitaxial Fe thin films, leading to an enhanced total damping at low temperature. The results suggest a correlation between interfacial magnetic anisotropy and two-magnon scattering.
Article
Cell Biology
Rosario Yerbes, Rocio Mora-Molina, F. Javier Fernandez-Farran, Laura Hiraldo, Abelardo Lopez-Rivas, Carmen Palacios
Summary: This study reveals a previously unknown cell death mechanism triggered in glutamine-addicted tumor cells in response to glutamine metabolism limitation. The mechanism is regulated by GCN2 activation induced by glutamine starvation and involves the activation of the extrinsic apoptotic pathway mediated by TRAIL-R2.
CELL DEATH & DISEASE
(2022)
Article
Environmental Sciences
Wenna Liu, Yujin Gan, Yun Ding, Lina Zhang, Xiaojing Jiao, Lu Liu, Huixia Cao, Yue Gu, Lei Yan, Yanliang Wang, Limeng Wang, Song Chen, Fengmin Shao
Summary: This study reveals the involvement of GSDME-mediated pyroptosis in cobalt-induced acute kidney injury (AKI), furthering the understanding of the regulatory mechanism of GSDME cleavage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Engineering, Biomedical
Xianzhou Huang, Chunqing Ou, Yaqian Shu, Yan Wang, Songlin Gong, Rui Luo, Shouchun Chen, Qinjie Wu, Changyang Gong
Summary: A novel multifunctional R6ST protein was designed to prepare a self-sustained nanoplatform (SSN) in order to reverse TRAIL-resistance of pancreatic cancer and improve circulation time. SSN exhibited synergistic antitumor effect by simultaneously promoting extrinsic and intrinsic apoptotic pathways, providing a new strategy for TRAIL-resistant pancreatic cancer therapy.
Article
Oncology
Ahmed A. Abd-Rabou, Hanaa H. Ahmed, Mohamed S. Kishta
Summary: In this study, aptamer nanoparticles loaded with viramidine (VRM) were used to interfere with hepatocellular carcinoma (HCC) cells through NO-mediated extrinsic and intrinsic apoptosis.
Article
Biochemistry & Molecular Biology
Hiroaki Ochiiwa, Guzhanuer Ailiken, Masataka Yokoyama, Kazuyuki Yamagata, Hidekazu Nagano, Chihoko Yoshimura, Hiromi Muraoka, Keiji Ishida, Tomonori Haruma, Akitoshi Nakayama, Naoko Hashimoto, Kazutaka Murata, Motoi Nishimura, Yusuke Kawashima, Osamu Ohara, Shuichi Ohkubo, Tomoaki Tanaka
Summary: TAS4464 induces apoptotic cell death in AML cell lines by activating both intrinsic and extrinsic apoptotic pathways, increasing NOXA expression and decreasing c-FLIP expression. This novel mechanism involves c-Myc-mediated apoptosis induction and leads to complete tumor remission in a human AML xenograft model.
Article
Biotechnology & Applied Microbiology
Siew Ching Ngai, Rozita Rosli, Akram Al Abbar, Syahril Abdullah
BIOMED RESEARCH INTERNATIONAL
(2015)
Review
Pharmacology & Pharmacy
Yuan-Seng Wu, Siew-Ching Ngai, Bey-Hing Goh, Kok-Gan Chan, Learn-Han Lee, Lay-Hong Chuah
FRONTIERS IN PHARMACOLOGY
(2017)
Review
Oncology
Sonia How Ming Wong, Chee Mun Fang, Lay-Hong Chuah, Chee Onn Leong, Siew Ching Ngai
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2018)
Review
Oncology
Yuan Seng Wu, Zhong Yang Lee, Lay-Hong Chuah, Chun Wai Mai, Siew Ching Ngai
CURRENT CANCER DRUG TARGETS
(2019)
Article
Genetics & Heredity
Siew Ching Ngai, Rozita Rosli, Norshariza Nordin, Abhi Veerakumarasivam, Syahril Abdullah
Article
Genetics & Heredity
Poh Tee Low, Mei I. Lai, Siew Ching Ngai, Syahril Abdullah
Review
Biotechnology & Applied Microbiology
Suleiman Yusuf Alhaji, Siew Ching Ngai, Syahril Abdullah
BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 35
(2019)
Review
Pharmacology & Pharmacy
Kar En Wong, Siew Ching Ngai, Kok-Gan Chan, Learn-Han Lee, Bey-Hing Goh, Lay-Hong Chuah
FRONTIERS IN PHARMACOLOGY
(2019)
Review
Oncology
Sonia How Ming Wong, Wei Yang Kong, Chee-Mun Fang, Hwei-San Loh, Lay-Hong Chuah, Syahril Abdullah, Siew Ching Ngai
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2019)
Article
Oncology
Zhi Hung Yap, Wei Yang Kong, Abdur Rahmaan Azeez, Chee-Mun Fang, Siew Ching Ngai
Summary: This study investigated the anti-cancer effects of epigenetic drugs scriptaid and zebularine in human breast adenocarcinoma cells. The results showed that these drugs inhibited cell migration and induced apoptotic features, suggesting their potential as anti-cancer drugs for breast cancer therapy.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Wei Yang Kong, Zong Yang Yee, Chun Wai Mai, Chee-Mun Fang, Syahril Abdullah, Siew Ching Ngai
Article
Multidisciplinary Sciences
Akram Al Abbar, Norshariza Nordinu, Siew Ching Ngai, Syahril Abdullah
PERTANIKA JOURNAL OF SCIENCE AND TECHNOLOGY
(2018)
Article
Multidisciplinary Sciences
Siew Ching Ngai, Rajesh Ramasamy, Syahril Abdullah
PERTANIKA JOURNAL OF SCIENCE AND TECHNOLOGY
(2012)