Article
Chemistry, Physical
Mengwei Sun, Ositomiwa O. Osipitan, Ewa K. Sulicz, Anthony J. Di Pasqua
Summary: Many patients have reported that lidocaine injections prior to facial plastic surgeries cause severe pain, and the lidocaine gels and creams currently available cannot provide an equal or better local anesthetic effect. To address this issue, researchers have developed a lidocaine gel formulated with ultraflexible liposomes, which has shown improved skin permeation ability and local analgesic effect.
Article
Biotechnology & Applied Microbiology
Cho Rim Kim, Eun Bi Jang, Seong Hwi Hong, Young Eun Yoon, Beom Kang Huh, Se Na Kim, Min Ji Kim, Hong Sang Moon, Young Bin Choy
Summary: The study proposed a urinary catheter with a drug-loaded polymer strand to relieve bladder discomfort caused by catheter insertion. The drug-delivery IUC showed sustained pain relief effects for up to 7 days and reduced the expression of pain-related inflammatory markers in biopsied bladder tissues.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Alireza Salabat, Elham Parsi
Summary: This study aimed to introduce new ionic liquid-based microemulsions and microemulgels as topical delivery systems for celecoxib. Ex-vivo diffusion results showed that the permeability of celecoxib in ILs/W formulations was higher and the release rate was faster compared to the O/W formulation, suggesting a more efficient drug delivery system.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Physical
Azar Kajbafvala, Alireza Salabat
Summary: This research investigated the development of a new microemulsion formulation for transdermal application of rutin. Through experimental design and physicochemical studies, it was found that the microemulsion formulation can effectively prolong the transdermal delivery of rutin.
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
(2022)
Article
Veterinary Sciences
Victoria Phillips, Stijn Schauvliege, Annelies Decloedt, Glenn Van Steenkiste, Gunther van Loon
Summary: This case report describes an appropriate anaesthetic protocol for cardiac three-dimensional electro-anatomical mapping and radiofrequency ablation in horses. The protocol included various drugs for premedication and anaesthetic induction, along with constant-rate infusions of lidocaine and medetomidine for maintaining hemodynamic stability. The anesthesia procedure was successful and the horse had a smooth recovery postoperatively.
VETERINARY RECORD CASE REPORTS
(2022)
Article
Pharmacology & Pharmacy
Pintu B. Prajapati, Khushbu Radadiya, Shailesh A. Shah
Summary: The study developed a chromatography method for simultaneous estimation of multiple fixed-dose combination products of metformin hydrochloride. The method was developed based on principles of quality risk management and design of experiments. It was found to be specific, accurate, and precise. Additionally, the method is versatile and eco-friendly, and can save solvent consumption.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2022)
Article
Pharmacology & Pharmacy
Pintu Prajapati, Hilomi Shah, Shailesh A. Shah
Summary: A chromatography method was developed using QRM and DoE-based approach for simultaneous analysis of multiple combined dosage forms of paracetamol. The optimized method showed consistent results with the labeled claims.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2022)
Article
Biochemical Research Methods
Gajanan G. Kalyankar, Prakruti N. Desai, Pintu B. Prajapati, Sandesh R. Lodha, Shrikant Joshi, Kunjan B. Bodiwala, Ashish A. Mishra, Shailesh A. Shah
Summary: A stability-indicating RP-HPLC method for pranlukast hydrate has been developed and validated, showing accuracy and precision for analysis of the drug in laboratory mixtures. The method includes stress testing under various conditions and meets the criteria set by the International Conference for Harmonization guidelines.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2022)
Article
Chemistry, Analytical
Pintu B. Prajapati, Ankita S. Patel, Shailesh A. Shah
Summary: An economical and eco-friendly RP-HPLC method has been developed for the analysis of fixed-dose combinations of anti-hypertensive drugs. The method was developed using an enhanced analytical quality by design approach and successfully fulfilled the requirements of published methods.
JOURNAL OF AOAC INTERNATIONAL
(2022)
Article
Biochemical Research Methods
Pintu Prajapati, Ankita Patel, Shailesh Shah
Summary: A multipurpose RP-HPLC method has been developed for synchronous estimation of telmisartan fixed-dose combination (FDC) products, providing an economical and eco-friendly alternative to other chromatography methods. The method parameters were assessed for risk and optimized using a full-factorial design, ensuring control of critical parameters throughout the method's lifecycle. The RP-HPLC method was successfully validated and used for simultaneous estimation of telmisartan FDC products, meeting the labeled claim. This method fulfills the requirements of various RP-HPLC and high-performance thin layer chromatography methods.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2022)
Article
Chemistry, Physical
Sachin Rathod, Rajesh Patidar, Debes Ray, Vinod K. Aswal, Shailesh A. Shah, Nihar Ranjan, Pratap Bahadur, Sanjay Tiwari
Summary: This study demonstrates that D-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) spherical micelles can transform into ellipsoid and cylindrical structures upon the addition of monosaccharides such as glucose, mannose, and galactose. Structural transitions are driven by sugar-induced dehydration in the head group region, with different sugars showing varying abilities to trigger these transitions. NMR experiments reveal structural reorganizations in TPGS molecule in the presence of sugars.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Pharmacology & Pharmacy
Furqan A. Maulvi, Prince A. Kanani, Harshani J. Jadav, Bhargavi Desai, Ditixa T. Desai, Hetal P. Patel, Kiran H. Shetty, Dinesh O. Shah, Mark D. P. Willcox
Summary: This study successfully improved the swelling and transmittance properties of contact lenses by incorporating graphene oxide (GO) during the fabrication process. Additionally, it achieved controlled release of timolol, a hydrophobic drug, through the use of GO-laden contact lenses.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kailas K. Moravkar, Devanshi S. Shah, Anuja G. Magar, Bhushan A. Bhairav, Sudarshan D. Korde, Ketan M. Ranch, Shailesh S. Chalikwar
Summary: This study evaluated and compared the flow properties of different lubricants during dosage form preparation. Traditional and advanced techniques were used to evaluate the flow properties of raw materials and granules. The addition of lubricants improved the flow behavior.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Microbiology
Christiane Lourenco Nogueira, Scott Joseph Boegel, Manish Shukla, William Ngo, Lyndon Jones, Marc G. Aucoin
Summary: This study investigated the impact of different contact lens care products on the infectiousness of two seasonal human coronaviruses. The results showed that oxidative disinfection systems exhibited significant virucidal activity, while non-oxidative systems showed minimal ability to inactivate the viruses.
Article
Pharmacology & Pharmacy
Sachin Rathod, Shristi Arya, Shirisha Kanike, Shailesh A. Shah, Pratap Bahadur, Sanjay Tiwari
Summary: This review discusses the approaches of improving solubilization and bioavailability of quercetin (QCT) using nanoformulations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Chandrasekhar Garapati, Sai HS. Boddu, Shery Jacob, Ketan M. Ranch, Chirag Patel, R. Jayachandra Babu, Amit K. Tiwari, Haya Yasin
Summary: Resistance to antimicrobial drugs is a growing healthcare problem. Photodynamic therapy, using photosensitizers activated by light, shows effectiveness against microbial cells. Nanocarrier systems can enhance the internalization of photosensitizers into microbial cells, improving therapeutic efficiency. This review highlights the principles of photodynamic therapy and emphasizes the use of nanosystems for antimicrobial photodynamic therapy.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Chirag Patel, Sonal Pande, Vrunda Sagathia, Ketan Ranch, Jayesh Beladiya, Sai H. S. Boddu, Shery Jacob, Moawia M. Al-Tabakha, Nageeb Hassan, Moyad Shahwan
Summary: Retinal neurodegeneration is an early event in the pathogenesis of ocular diseases, and there is currently no definitive treatment to prevent vision loss caused by photoreceptor degeneration. Neuroprotective approaches are being developed to maintain neuronal shape/function and prevent vision loss. Recent advancements in nanotechnology-based drug delivery systems show promise in treating ocular neurodegenerative diseases.
Article
Biochemical Research Methods
Pintu Prajapati, Abhinandan Shahi, Aneri Acharya, Veera Shakar Pulusu, Shailesh Shah
Summary: According to the principles of WAC, it is important to avoid using teratogenic and carcinogenic organic solvents in order to protect the environment and analysts. Therefore, a green RP-HPLC method based on WAC was developed and validated for the simultaneous analysis of anti-hypertensive drugs in human plasma. The development of the method was guided by the analytical quality by design approach and involved the optimization of critical method variables using design of experiments and chemometrics concepts.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Palak K. Parikh, Nisha H. Parikh, B. Mahalakshmi, Ketan M. Ranch, Sai H. S. Boddu, R. Jayachandra Babu, Amit K. Tiwari
Summary: Given the continuous emergence of hepatitis and the associated consequences, developing effective antiviral strategies has become a major public health concern. Current antiviral strategies for hepatitis, especially for HBV and HCV, include small molecule modulators, peptides, nucleic acid polymers, siRNA, antisense oligonucleotides, monoclonal antibodies, and vaccines. Small molecule antiviral agents targeting HBV and HCV have advanced into different phases of clinical investigation, mainly targeting complex molecular interactions between virus and host cells involved in viral replication.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Sai H. S. Boddu, Devarshi Acharya, Vivek Hala, Harshil Jani, Sonal Pande, Chirag Patel, Moyad Shahwan, Renukuntla Jwala, Ketan M. Ranch
Summary: Advancements in protein engineering, biotechnology, and structural biochemistry have increased the utilization of proteins and peptides in the treatment of ocular diseases. However, the delivery of large molecules to the eye is challenging due to their properties. Various strategies such as glycoengineering, PEGylation, Fc-fusion, chitosan nanoparticles, and liposomes have improved the efficacy, safety, and stability of protein and peptide delivery.
Article
Biophysics
Cristina Potrich, Anna Pedrotti, Cecilia Pederzolli, Lorenzo Lunelli
Summary: This study developed different functional surfaces for capturing exosomes and verified their effectiveness through experiments. Among them, the negatively-charged surface performed the best, capturing a large number of exosomes and successfully analyzing their biomarkers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Brojendra Nath Saren, Srushti Mahajan, Mayur Aalhate, Rahul Kumar, Essha Chatterjee, Indrani Maji, Ujala Gupta, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: This study developed P-selectin-targeted dasatinib nanoparticles coated with chitosan and fucoidan (DST-CH-FUC-NPs), which showed sustained release, reduced hemolytic potential, increased cytotoxicity and cellular uptake compared to free dasatinib. These nanoparticles also demonstrated enhanced ROS production, mitochondrial membrane potential damage, apoptosis induction, cell migration inhibition, and disruption of lysosomal membrane integrity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Weiping Deng, Xiaohui Li, Ya Li, Zhongbing Huang, Yulin Wang, Ning Mu, Juan Wang, Tunan Chen, Ximing Pu, Guangfu Yin, Hua Feng
Summary: This study demonstrates the importance of chirality in nerve repair by constructing a GO-phenylalanine derivative hydrogel system. In vivo experiments show that the dextro group significantly improves functional recovery and histological restoration in rat sciatic nerve repair models. The doped GO promotes angiogenesis and myelination. These results suggest that chirality plays a crucial role in promoting nerve regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xiaoyan Wang, Jin Gao, Yu Gao, Linlin Zhang, Congchao Xu, Qintong Li, Lin Li, Jianliang Xue
Summary: In this study, a highly effective surfactant producer strain, Bacillus Cereus GX7, was isolated from the oil tank bottom sludge of Shengli Oil Field in China. The biosurfactant produced by GX7 was identified as surfactin, a lipopeptide surfactant, through TLC, FT-IR, and LC-MS/MS analysis. The fermentation process of GX7 was optimized using single-factor experiments, focusing on the composition of fermentation medium and fermentation conditions. Glucose and peptone were found to be the best carbon and nitrogen sources, and the optimum temperature, inoculum amount, pH, rotation speed, and fermentation time for the strain were determined to be 30°C, 1%, 7.5, 150 rpm, and 48 h, respectively. After optimization, the surface tension and emulsification index of the fermentation broth were 26.84 mN/m and 57.84%, respectively. Furthermore, the biosurfactant produced by GX7 demonstrated good stability over a wide range of temperature, pH, and salt concentration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Rodney Marcelo do Nascimento, Christine Grauby-Heywang, Houssem Kahli, Nesrine Debez, Laure Beven, Ivan Helmuth Bechtold, Touria Cohen Bouhacina
Summary: This article presents a theoretical model based on thermodynamic rules to assess the early stages of bacterial biofilm formation on different material surfaces. By utilizing morphological characteristics of bacteria and Atomic Force Microscopy images, the model generates a dataset of energetically minimized states, which can be correlated with bacterial adhesion states.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Filipa A. L. S. Silva, Licinia Timochenco, Raquel Costa-Almeida, Jose Ramiro Fernandes, Susana G. Santos, Fernao D. Magalhaes, Artur M. Pinto
Summary: The study demonstrates that by photoreducing nanosized graphene oxide using ultraviolet radiation, nanometric particles with high light-to-heat conversion efficiency and water stability can be obtained. These nanomaterials exhibit high absorption in the near-infrared region and show no cytotoxicity towards human cells, indicating their potential for safe therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
D. Costa, V. De Matteis, F. Treso, G. Montani, M. Martino, R. Rinaldi, M. Corrado, M. Cascione
Summary: This review primarily discusses the relationship between contact lens discomfort (CLD) and the surface properties of contact lenses (CLs), specifically the coefficient of friction (CoF). The review emphasizes the importance of introducing a standardized protocol for measuring CoF and calls for a more precise evaluation of the relationship between surface properties and comfort in CLs users.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Debdip Brahma, Tamal Sarkar, Rupal Kaushik, Akshay Narayan Sarangi, Amar Nath Gupta
Summary: This in-vitro study evaluates the effect of reactive oxygen species (ROS) on the structural rearrangement of elastin. The results show that oxidative stress leads to a decrease in protein size and changes in secondary structure, potentially promoting protein aggregation. This study is important for therapeutics aiming to prevent elastin degradation and aging.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Xin Yang, Qiang Wang, Chaoxi Yan, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Pingbo Chen, Tingjun Ye, Dan Hu, Lei Wang
Summary: This study presents a practical and effective strategy to improve osseointegration in patients with osteoporosis. By coating titanium implants with polydopamine followed by strontium modification, the bi-functional implants promote bone regeneration and immune regulation. The results show good biocompatibility, sustained release of strontium ions, and stable osseointegration between bone tissues and implants.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Sengwang Fu, Jianping Zhu, Zhijun Jiang, Yue Cao, Yufei Chen, Lihao Zhang, Sunlong Li, Weipeng Lu, Chengbin Miao, Qing He, Qi Li, Weixing Zhang, Lehao Ren, Yachun Li, Hongchao Shi, Cihui Liu
Summary: Effective management of biofluids is crucial for in vivo surgical interventions. Recent advances include self-sealing needles, drug-eluting stents, and shear-thinning hydrogels. However, complications associated with intestinal mucosal injury and secondary damage still persist. In this study, researchers developed an interpenetrating Janus wettability stent coating that enables unidirectional draining of excessive biofluid. They also demonstrated directional biofluid movement using a self-pumping dressing with potential applications in biofluid collection and disease diagnosis through metal ion detection. This integrated system presents an opportunity for designing wound dressings with effective biofluid management and metal ion detection capabilities.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Maryam Hassani, Mojtaba Kamankesh, Mazda Rad-Malekshahi, Kobra Rostamizadeh, Farhad Rezaee, Ismaeil Haririan, Seyed Mojtaba Daghighi
Summary: Bacterial adhesion and biofilm formation on the surface of biomaterial implants is a critical problem, and a polymer brush coating with antiadhesive and antimicrobial properties has proven to be highly effective in resolving this issue.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Huaihong Zhang, Na Liu, Yuting Zhang, Hui Cang, Zhaosheng Cai, Ziqun Huang, Jun Li
Summary: A functionalized cationic polymer, CR-PQAC, was designed and synthesized for photothermal enhanced antimicrobial therapy. The CR-PQAC nanoparticles exhibited significant antibacterial activity and low cytotoxicity against mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Ipsita Sahu, Priyadarshi Chakraborty
Summary: Peptide nanotechnology bridges the gap between materials and biological worlds by utilizing self-assembly of short-peptide building blocks. Hydrogels engineered from these short peptides show great potential in biomedical applications, but their weak mechanical properties and limited functional diversity need to be addressed. Nanoengineering the networks of these hydrogels by incorporating small molecules, polymers, and inorganic/carbon nanomaterials can enhance their mechanical properties and expand their functional diversity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Hao Wei, Yajun Gu, Ao Li, Panpan Song, Dingding Liu, Feihu Sun, Xiaofeng Ma, Xiaoyun Qian
Summary: In this study, a stable three-dimensional conductive hydrogel was prepared by cross-linking MXenes to Matrigel hydrogel. The conductive hydrogel promotes the proliferation and differentiation of NSCs, providing new strategies for neural tissue engineering.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)
Article
Biophysics
Yue Zhong, Xiaoli Ge, Juan Zhang, Qun Wei, Feng Wang, Yongke Zhong
Summary: The effect of oxygenic groups on the hemocompatibility of activated carbon was studied through liquid-phase oxidation and subsequent heat treatment. Results showed that the presence of oxygenic groups improved hemocompatibility, while their removal decreased it.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2024)