Journal
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
Volume 587, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.colsurfa.2019.124363
Keywords
Inverse miniemulsion; Responsive polymer/Fe3O4 nanocomposite nanogels; Drug nanocarrier; Magnetic; Multi-responsiveness
Categories
Funding
- National Natural Science Foundation of China (NNSFC) project [51573168, 21908200]
- Science Foundation of Zhejiang Sci-Tech University [14012208-Y]
- Excellent Young Researchers Foundation of Zhejiang Provincial Top Key Academic Discipline of Chemical Engineering and Technology [CETT2015001]
- National Undergraduate Training Programs for Innovation and Entrepreneurship of China [201910338041]
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This work reports the synthesis of novel degradable magnetic temperature- and redox-responsive polymer/Fe3O4 nanocomposite nanogels (NCGs) through inverse miniemulsion polymerization and their potential application as nanocarriers for controlled drug delivery. Surface of Fe3O4 magnetic nanoparticles (MNPs) were vinyl-modified with 2-isocyanatoethyl methacrylate. Poly(N-vinylcaprolactam) (PNVCL)/Fe3O4 NCGs were prepared via inverse miniemulsion polymerization by using a disulfide-containing cross-linker. The Fe3O4 MNPs were chemically attached to the polymer matrix of NCGs, offering a good structural integrity of NCGs in aqueous systems. The PNVCL/Fe3O4 NCGs not only inherited the good superparamagnetism of Fe3O4 MNPs, but also displayed a reversible temperature-responsiveness as well as marked redox-responsiveness. The release behavior of a model anticancer drug 5-fluorouracil from the PNVCL/Fe3O4 NCGs could be conveniently tuned by the external temperature, redox condition of media, or their combination. The prepared PNVCL/Fe3O4 NCGs displayed a low cytotoxicity, holding a great potential in functioning as magnetic guiding nanocarriers for controlled drug delivery.
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