Journal
CLINICS IN CHEST MEDICINE
Volume 41, Issue 1, Pages 25-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccm.2019.10.003
Keywords
Biology of lung cancer; NSCLC and SCLC; Genomic alterations; Tumor microenvironment; Lung cancer prevention; Lung cancer early detection; Targeted therapy; Immunotherapy
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Lung cancer is a heterogeneous disease with abundant genomic alterations. Chronic dysregulated airway inflammation facilitates lung tumorigenesis. In contrast, antitumor host immune responses apply continuous selective pressure on the tumor cells during the evolutionary course of the disease. Unprecedented advances in integrative genomic, epigenomic, and cellular profiling of lung cancer and the tumor microenvironment are enhancing the understanding of pulmonary tumorigenesis. This understanding in turn has led to advancements in lung cancer prevention and early detection strategies, and the development of effective targeted therapies and immunotherapies with survival benefit in selected patients.
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