Down-regulation of placental Cdc42 and Rac1 links mTORC2 inhibition to decreased trophoblast amino acid transport in human intrauterine growth restriction

Complex, coordinated and highly regulated changes in placental signaling and nutrient transport capacity in IUGR

(2019) Stephanie Chassen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Dual inhibition of mTORC1 and mTORC2 perturbs cytoskeletal organization and impairs endothelial cell elongation

(2018) Kiyomi Tsuji-Tamura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanistic Target of Rapamycin Is a Novel Molecular Mechanism Linking Folate Availability and Cell Function

(2017) Elena Silva et al.   JOURNAL OF NUTRITION

1,25-Dihydroxy vitamin D3 stimulates system A amino acid transport in primary human trophoblast cells

(2017) Yi-Yung Chen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Promoting Glucose Transporter-4 Vesicle Trafficking along Cytoskeletal Tracks: PAK-Ing Them Out

(2017) Ragadeepthi Tunduguru et al.   Frontiers in Endocrinology

Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons

(2016) P. Pantham et al.   BIOLOGY OF REPRODUCTION

Isolation of basal membrane proteins from BeWo cells and their expression in placentas from fetal growth-restricted pregnancies

(2016) Soo-young Oh et al.   PLACENTA

Reduced placental amino acid transport in response to maternal nutrient restriction in the baboon

(2015) Priyadarshini Pantham et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR

(2015) Y.-Y. Chen et al.   CLINICAL SCIENCE

Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2

(2015) F. J. Rosario et al.   CLINICAL SCIENCE

Nutrient-sensing mechanisms and pathways

(2015) Alejo Efeyan et al.   NATURE

Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth

(2015) Fredrick J. Rosario et al.   Obesity

Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth

(2015) Irving L. M. H. Aye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression and functional characterisation of System L amino acid transporters in the human term placenta

(2015) Francesca Gaccioli et al.   Reproductive Biology and Endocrinology

Role of Placental Nutrient Sensing in Developmental Programming

(2013) THOMAS JANSSON et al.   CLINICAL OBSTETRICS AND GYNECOLOGY

Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon

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Roles of Rho GTPases in Intracellular Transport and Cellular Transformation

(2013) Xiaojuan Chi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac/Cdc42 activity and the actin cytoskeleton

(2013) Yuan He et al.   MOLECULAR BIOLOGY OF THE CELL

mTORC2 controls actin polymerization required for consolidation of long-term memory

(2013) Wei Huang et al.   NATURE NEUROSCIENCE

SNAT2 expression and regulation in human growth-restricted placentas

(2013) Chiara Mandò et al.   PEDIATRIC RESEARCH

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Activation of Placental mTOR Signaling and Amino Acid Transporters in Obese Women Giving Birth to Large Babies

(2012) Nina Jansson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mammalian target of rapamycin signalling modulates amino acid uptake by regulating transporter cell surface abundance in primary human trophoblast cells

(2012) Fredrick J. Rosario et al.   JOURNAL OF PHYSIOLOGY-LONDON

Amino acids and mTORC1: from lysosomes to disease

(2012) Alejo Efeyan et al.   TRENDS IN MOLECULAR MEDICINE

Maternal Protein Restriction in the Rat Inhibits Placental Insulin, mTOR, and STAT3 Signaling and Down-Regulates Placental Amino Acid Transporters

(2011) Fredrick J. Rosario et al.   ENDOCRINOLOGY

Facilitated transporters mediate net efflux of amino acids to the fetus across the basal membrane of the placental syncytiotrophoblast

(2011) J. K. Cleal et al.   JOURNAL OF PHYSIOLOGY-LONDON

mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion

(2010) Lunhua Liu et al.   DEVELOPMENTAL CELL

New Insights into mTOR Signaling: mTORC2 and Beyond

(2009) D. R. Alessi et al.   Science Signaling

Evidence of Placental Translation Inhibition and Endoplasmic Reticulum Stress in the Etiology of Human Intrauterine Growth Restriction

(2008) Hong-wa Yung et al.   AMERICAN JOURNAL OF PATHOLOGY

BCH, an Inhibitor of System L Amino Acid Transporters, Induces Apoptosis in Cancer Cells

(2008) Chun Sung Kim et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Effect of In Utero and Early-Life Conditions on Adult Health and Disease

(2008) Peter D. Gluckman et al.   NEW ENGLAND JOURNAL OF MEDICINE