Article
Immunology
Jeremy Anderson, Cao Minh Thang, Le Quang Thanh, Vo Thi Trang Dai, Van Thanh Phan, Bui Thi Hong Nhu, Do Ngoc Xuan Trang, Phan Thi Phuong Trinh, Thuong Vu Nguyen, Nguyen Trong Toan, Christopher M. Harpur, Kim Mulholland, Daniel G. Pellicci, Lien Anh Ha Do, Paul Licciardi
Summary: Immature immune system of preterm infants leads to distinct differences in immune profiles compared to full-term infants, particularly in pro-inflammatory cytokines and chemokines. These differences may contribute to the increased susceptibility of preterm infants to infectious diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Li-Fang Chou, Chih-Wei Huang, Huang-Yu Yang, Ya-Chung Tian, Ming-Yang Chang, Cheng-Chieh Hung, Kuan-Hsing Chen, Shen-Hsing Hsu, Chung-Ying Tsai, Yi-Ching Ko, Ting-Wen Chen, Chih-Wei Yang
Summary: This study analyzed the transcriptome profiles of mice kidneys with adenine-induced and chronically Leptospira-infected kidneys to understand the combined effect. The findings showed that chronic inflammation and T-helper 17 immune responses were activated, and there was high expression of Indoleamine 2,3-dioxygenase 1 protein. These results suggest that the combination may lead to chronic inflammation, kidney function disruption, and symptoms of chronic kidney disease. Additionally, immunometabolic regulation may contribute to renal injury caused by chronic leptospirosis with secondary nephrotoxic injury. The study identified disrupted genes that could be potential targets for CKD diagnosis or treatment, providing insight into the molecular basis for rapid progression of CKD.
Article
Orthopedics
Thomas Bitterli, David Schmid, Ladina Ettinger, Olga Krupkova, Frances C. Bach, Marianna A. Tryfonidou, Bjorn P. Meij, Antonio Pozzi, Frank Steffen, Karin Wuertz-Kozak, Lucas A. Smolders
Summary: This study investigated the expression of inflammatory mediators in degenerated ligamentum flavum (LF) and intervertebral disc (IVD) and identified potential treatment targets. Various TNFSF members were significantly regulated in the degenerated IVD, while TNFSF genes were not significantly affected in the degenerated LF. The study also found changes in the expression of NGF and RANKL proteins.
Article
Gastroenterology & Hepatology
Asami Izu, Masahiko Sugitani, Noriko Kinukawa, Hiroshi Matsumura, Masahiro Ogawa, Mitsuhiko Moriyama, Shintaro Yamazaki, Tadatoshi Takayama, Hiroshi Hano, Takashi Yao, Hiroaki Kanda, Koyu Suzuki, Seisyu Hayashi, Syunichi Ariizumi, Masakazu Yamamoto, Yukio Morishita, Koshi Matsumoto, Naoya Nakamura, Masayuki Nakano
Summary: In Japanese HCA cases, the proportions of U-HCA, male and elder cases were slightly higher than in Western countries, and most of elder patients were male. However, IHCA was common regardless of race, and was assumed to be the predominant subtype of HCA.
HEPATOLOGY RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
Zhong-mian Zhang, Zi-li Lin, Bai-xiang He, Wei-tian Yan, Xi-yan Zhang, Zhong-han Zhang, Lan Wang, Jia-qi Wang, Da-ming Liu, Wen Zhang, Zhi-hong Li
Summary: The prevalence and incidence rate of inflammatory bowel disease (IBD) among children and adolescents have been increasing globally in the past 30 years, while the DALYs and mortality have been decreasing. The rising prevalence and incidence in areas with historically low rates will have significant health and economic implications.
JOURNAL OF GLOBAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Nery E. Linarez Ochoa, Gaspar Rodriguez, Irma Dolores Reyes, Karla M. Rico Rivas, Celeo Ramirez, Reyna M. Duron
Summary: This study compared inflammatory markers between patients with COVID-19 and those with bacterial sepsis. The results showed that ferritin was the main inflammatory marker for COVID-19, while leukocytes, procalcitonin, and D-dimer were the main markers for sepsis. The therapeutic implications of these differences require further study.
CLINICAL EPIDEMIOLOGY AND GLOBAL HEALTH
(2022)
Review
Health Care Sciences & Services
Jose Alberto Israel Romero Rangel, Fiacro Jimenez Ponce, Rosa Maria Wong Chew, Juan Osvaldo Talavera Pina, Adolfo Martinez Tovar
Summary: This study aims to determine the behavior profile of inflammatory biomarkers in patients undergoing elective degenerative spine surgery and compare it with those experiencing postoperative spinal infections (PSIs). The study will include biomarker-related research in adult patients with degenerative spinal diseases and those developing PSIs. The research findings are expected to be published in mid-2023, providing reliable reference values for PSI diagnosis.
JMIR RESEARCH PROTOCOLS
(2023)
Letter
Rheumatology
Alessandro Giollo, Riccardo Bixio, Davide Gatti, Ombretta Viapiana, Luca Idolazzi, Christian Dejaco, Maurizio Rossini
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Dermatology
Francesco Bellinato, Giovanni Adami, Silvia Vaienti, Camilla Benini, Davide Gatti, Luca Idolazzi, Angelo Fassio, Maurizio Rossini, Giampiero Girolomoni, Paolo Gisondi
Summary: The findings of this study suggest that air pollution may be a trigger factor for psoriasis flare.
Letter
Rheumatology
D. Bertelle, E. Bertoldo, R. Bixio, M. Rossini
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Giovanni Adami, Pietro Olivi, Marco Pontalti, Camilla Benini, Leandro Ramazzini, Bruno Magnan, Eugenia Bertoldo, Davide Gatti, Angelo Fassio, Maurizio Rossini, Stefano Negri
Summary: This study found that exposure to PM10 pollution is associated with an increased risk of fragility hip fractures. The risk was found to increase by 7.7% for every 10 μg/m3 increase in PM10 concentration. Further research is needed to determine the exact role of air pollution in fracture risk.
Letter
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Angelo Fassio, Ombretta Viapiana, Maurizio Rossini
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Rheumatology
Giovanni Adami, Angelo Fassio, Maurizio Rossini, Davide Bertelle, Francesca Pistillo, Camilla Benini, Ombretta Viapiana, Davide Gatti
Summary: Reducing glucocorticoid doses in rheumatoid arthritis patients can effectively decrease the risk of disease flare-ups. However, choosing the right tapering strategy remains challenging. The study found that tapering glucocorticoids to doses of 2.5 mg/day or below was associated with a higher risk of flare, suggesting the need for better tapering strategies to reduce the risk of recurrence in rheumatoid arthritis patients on biological disease-modifying antirheumatic drugs.
Article
Rheumatology
Giovanni Orsolini, Francesca Mastropaolo, Eleonora Favaro, Anna Piccinelli, Davide Bertelle, Ombretta Viapiana, Maurizio Rossini, Riccardo Bixio
Summary: The aim of this study was to characterize lupus-related arthritis and assess the efficacy of belimumab in treating articular manifestations of SLE. The results showed that belimumab treatment significantly improved disease activity in patients without erosions, but had no effect on patients with erosions. Additionally, the presence of ultrasound-detected erosions was associated with a decreased efficacy of belimumab. However, further research is needed to confirm these findings due to the small sample size.
CLINICAL RHEUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Margherita Zen, Mariele Gatto, Roberto Depascale, Francesca Regola, Micaela Fredi, Laura Andreoli, Franco Franceschini, Maria Letizia Urban, Giacomo Emmi, Fulvia Ceccarelli, Fabrizio Conti, Alessandra Bortoluzzi, Marcello Govoni, Chiara Tani, Marta Mosca, Tania Ubiali, Maria Gerosa, Enrica P. Bozzolo, Valentina Canti, Paolo Cardinaletti, Armando Gabrielli, Giacomo Tanti, Elisa Gremese, Ginevra De Marchi, Salvatore De Vita, Serena Fasano, Francesco Ciccia, Giulia Pazzola, Carlo Salvarani, Simone Negrini, Andrea Di Matteo, Rossella De Angelis, Giovanni Orsolini, Maurizio Rossini, Paola Faggioli, Antonella Laria, Matteo Piga, Alberto Cauli, Salvatore Scarpato, Francesca Wanda Rossi, Amato De Paulis, Enrico Brunetta, Angela Ceribelli, Carlo Selmi, Marcella Prete, Vito Racanelli, Angelo Vacca, Elena Bartoloni, Roberto Gerli, Elisabetta Zanatta, Maddalena Larosa, Francesca Saccon, Andrea Doria, Luca Iaccarino
Summary: This study assessed the efficacy of belimumab in treating joint and skin manifestations in a nationwide cohort of SLE patients. The results showed that belimumab significantly improved joint and skin symptoms and reduced the use of glucocorticoids. A significant proportion of patients who did not achieve complete remission initially achieved remission during follow-up.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Rheumatology
G. Adami, L. Idolazzi, C. Benini, E. Fracassi, A. Carletto, O. Viapiana, D. Gatti, M. Rossini, A. Fassio
Summary: Psoriatic arthritis (PsA) is effectively treated with biological disease-modifying antirheumatic drugs (bDMARDs). A real-life observational study was conducted to compare the retention rates of IL-17 inhibitors and TNF inhibitors in PsA patients. The study found that secukinumab had a trend towards better retention rate compared to TNF inhibitors, especially in patients with axial involvement.
Letter
Rheumatology
Giovanni Adami, Camilla Benini, Elisabetta Vantaggiato, Denise Rotta, Ombretta Viapiana, Davide Gatti, Maurizio Rossini, Annamaria Iagnocco
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Giovanni Adami, Angelo Fassio, Francesca Pistillo, Camilla Benini, Ombretta Viapiana, Maurizio Rossini, Davide Gatti
Summary: This study aimed to investigate the factors associated with radiological progression in rheumatoid arthritis (RA) patients treated with biological DMARDs (bDMARDs). The results showed that baseline erosive disease, higher disease activity during treatment, younger age, and monotherapy were independently associated with the development of bone erosions. Additionally, the study team developed a predictive model that accurately forecasted the occurrence of new erosions in patients receiving bDMARDs.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Correction
Dermatology
Francesco Bellinato, Paolo Gisondi, Emilio Filippucci, Francesca Tozzi, Angelo Fassio, Giovanni Adami, Luca Idolazzi
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
