Article
Medicine, General & Internal
Seong Hoon Bae, Seo Jin Moon, Jeong Gum Lee, Yun Kyung Yim, Hee So Oh, Dong Hee Han, In Seok Moon
Summary: The study compared the effects of rTMS and tDCS treatments for chronic tinnitus, showing comparable results in reducing tinnitus symptoms, with tDCS possibly being more cost-effective.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychiatry
Ronald E. See, Branon Eusebio, David Agnew, Mark Heatwole
Summary: The study found that steroid hormones may not be reliable biomarkers of treatment response in patients with major depressive disorder undergoing repetitive transcranial magnetic stimulation (rTMS). While rTMS significantly improved symptoms, salivary biomarker levels did not show significant changes during the treatment sessions.
PSYCHIATRY RESEARCH
(2021)
Review
Clinical Neurology
Danielle Hett, Jack Rogers, Clara Humpston, Steven Marwaha
Summary: The existing literature suggests that rTMS could be effective in reducing depressive symptoms in adolescents, yet caution is needed due to the lack of sham controlled randomized trials. The studies suffered from multiple biases, limiting the interpretation and generalization of the results.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Daphne Voineskos, Daniel M. Blumberger, Nigel C. Rogasch, Reza Zomorrodi, Faranak Farzan, George Foussias, Tarek K. Rajji, Zafiris J. Daskalakis
Summary: The study found that repetitive transcranial magnetic stimulation (rTMS) can reduce neurophysiological markers of inhibition and excitability in treating treatment resistant depression (TRD), revealing potential important neurophysiological mechanisms of action for rTMS.
CLINICAL NEUROPHYSIOLOGY
(2021)
Review
Clinical Neurology
Gerasimos Konstantinou, Jeanette Hui, Abigail Ortiz, Tyler S. Kaster, Jonathan Downar, Daniel M. Blumberger, Zafiris J. Daskalakis
Summary: There is limited evidence on the use of rTMS in bipolar disorder, with mixed findings and no consensus on the most effective protocol. More adequately powered studies are needed to verify its efficacy and explore its effects on manic and mixed episodes.
Review
Neurosciences
Ferran Cuenca-Martinez, Nuria Sempere-Rubio, Sara Molla-Casanova, Elena Munoz-Gomez, Josue Fernandez-Carnero, Alberto Sanchez-Sabater, Luis Suso-Marti
Summary: This study aimed to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) in patients with fibromyalgia (FMS). Eleven systematic reviews were included in the analysis. The results showed that high-frequency rTMS significantly reduced pain intensity at a 1-month follow-up, while the effects of low-frequency rTMS were uncertain. There was a significant effect on pain intensity up to 1-week post-intervention for the combination of high and low-frequency rTMS, but the results were controversial in the follow-up. rTMS was effective in improving general health but not in managing depressive symptoms and anxiety.
Article
Psychiatry
Ferron F. Ocampo, Alexandria E. Matic, Monina G. Cruz, Ludwig F. Damian
Summary: rTMS is an effective treatment option for catatonic patients who do not respond to pharmacotherapy or are unable to undergo ECT.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Review
Medicine, General & Internal
Minoo Sharbafshaaer, Ilaria Gigi, Luigi Lavorgna, Sabrina Esposito, Simona Bonavita, Gioacchino Tedeschi, Fabrizio Esposito, Francesca Trojsi
Summary: This review summarizes the effectiveness of repetitive transcranial magnetic stimulation (rTMS) in patients with mild cognitive impairment (MCI) and explores potential neuromodulation approaches using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI). The results suggest that rTMS is safe and effective for enhancing cognitive functions in MCI patients, with changes in functional connectivity as a potential indicator of treatment response. High-frequency rTMS over the dorsolateral prefrontal cortex (DLPFC) has shown significant improvement in executive performance and functional connectivity within frontoparietal networks. Neuroimaging techniques combined with rTMS offer promising network-based, fMRI-guided therapeutic approaches.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Microbiology
Blaine A. Mathison, Richard S. Bradbury, Bobbi S. Pritt
Summary: The taxonomy of parasites of medical and public health importance is rapidly evolving, with established human parasites being reassigned to different genera and novel parasites of humans being identified in the past two years.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Neurosciences
Olivia Verisezan Rosu, Nicoleta Jemna, Elian Hapca, Irina Benedek, Iulia Vadan, Ioana Muresanu, Diana Chira, Constantin Radu, Razvan Chereches, Stefan Strilciuc, Dafin Muresanu
Summary: This randomized controlled trial investigated the safety and efficacy of combining repetitive transcranial magnetic stimulation (rTMS) and Cerebrolysin in improving cognitive and functional outcomes in TBI patients. The study results demonstrated that the combined intervention of rTMS and Cerebrolysin was safe and well-tolerated by patients with TBI. Although no statistically significant differences were observed in the primary outcome measures, the descriptive trends in the study support existing literature on the efficacy and safety of rTMS and Cerebrolysin.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Jessica A. Michael, Manreena Kaur
Summary: This passage discusses the growing interest in the frontal-vagal network theory of major depressive disorder and the potential role of a frontal-vagal network in rTMS treatment for MDD. It highlights the established concept of ANS dysfunction in MDD and the effect of different antidepressants on ANS function. Additionally, it mentions the potential of using ANS measures to inform response to antidepressant medication treatment and the preliminary evidence supporting rTMS in alleviating ANS dysfunction in MDD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Rehabilitation
Jun Zhang, Dongling Zhong, Xili Xiao, Li Yuan, Yuxi Li, Yaling Zheng, Juan Li, Tianyu Liu, Rongjiang Jin
Summary: The study evaluated the effects and safety of rTMS on aphasia in stroke patients, finding that rTMS was more effective in language recovery compared to sham and conventional rehabilitation, especially low-frequency and bilateral rTMS. However, the quality of evidence for all outcomes was low, with potential publication bias.
CLINICAL REHABILITATION
(2021)
Article
Clinical Neurology
Luca L. Silva, Mehmet S. Tuncer, Peter Vajkoczy, Thomas Picht, Tizian Rosenstock
Summary: This study evaluates the clinical utility of different methods for DTI-FT of subcortical language pathways. Anatomical landmark-based approaches achieve the highest success and accuracy rates, while rTMS-based approaches frequently fail to reveal streamlines and provide less complete tractograms.
JOURNAL OF NEUROSURGERY
(2022)
Review
Medicine, General & Internal
Aurelia Gay, Julien Cabe, Ingrid De Chazeron, Celine Lambert, Maxime Defour, Vikesh Bhoowabul, Thomas Charpeaud, Aurore Tremey, Pierre-Michel Llorca, Bruno Pereira, Georges Brousse
Summary: This meta-analysis examines the therapeutic potential of repetitive transcranial magnetic stimulation (rTMS) on addiction by targeting craving. The results suggest that active rTMS has a small effect in reducing craving, particularly in stimulant and behavioral addiction. No significant differences were found in the different combinations of target and frequency of stimulation, but a correlation between number of sessions and craving reduction was observed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Xuemei Zong, Jie Gu, Deqin Geng, Dianshuai Gao
Summary: rTMS has shown promising therapeutic value in rodent models of stroke, Alzheimer's disease, vascular dementia, and Parkinson's disease. However, the optimal protocols and exact target of action for this therapy remain to be determined. Therefore, further research is needed to bridge the translation gap between rodent experiments and clinical application, which might lead to new directions in the treatment of multiple neurological disorders.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Review
Neurosciences
Maximilian J. Wessel, Laurijn R. Draaisma, Friedhelm C. Hummel
Summary: This narrative review summarizes current studies employing the cerebellar transcranial alternating current stimulation technique (CB-tACS) and discusses open research questions. CB-tACS may contribute to the understanding of cerebellar oscillatory signatures and their role in motor, cognitive, or affective functions. In the long term, CB-tACS could develop into a therapeutic tool for retuning disturbed oscillatory activity in cerebellar networks underlying brain disorders.
Article
Engineering, Biomedical
Claudia Bigoni, Andeol Cadic-Melchior, Takuya Morishita, Friedhelm C. Hummel
Summary: This study investigated the effects of different signal processing pipelines on brain-state forecasting approaches. The grid-search method was used to identify the most optimal preprocessing parameters and phase-forecasting algorithms. The results showed that different processing pipelines led to different results, and the chosen pipelines significantly increased the accuracy of forecasting methods. The successful results in stroke patients indicate the potential of state-dependent interventional treatment approaches.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Clinical Neurology
Simone Rossi, Gionathan Mazza, Massimiliano Del Testa, Alessandro Giannotta, Sabina Bartalini, Elisa Testani, Laura Savelli, Mario Gabbrielli, Giampaolo Vatti, Sabino Scolletta
Summary: This study aimed to verify the usefulness of electroencephalographic (EEG) activity recording in addition to clinical evaluations in determining brain death. The study analyzed data from all brain death determination cases in the past 10 years and found that repeating a 30-minute EEG twice over a 6-hour period did not provide additional useful information beyond the initial clinical evaluations.
NEUROLOGICAL SCIENCES
(2023)
Article
Psychology, Clinical
Jerome Brunelin, Filipe Galvao, Marine Mondino
Summary: This retrospective study investigated the therapeutic effect of repetitive transcranial magnetic stimulation (rTMS) in patients with treatment-resistant auditory verbal hallucinations. The results showed that low frequency rTMS could significantly decrease these symptoms.
INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
(2023)
Review
Rehabilitation
Ishtiaq Ahmed, Rustem Mustafaoglu, Simone Rossi, Fatih A. Cavdar, Seth Kwame Agyenkwa, Marco Y. C. Pang, Sofia Straudi
Summary: This study compared the efficacy of non-invasive brain stimulation techniques in upper limb stroke rehabilitation. The results indicated that excitatory stimulation protocols showed the most promising effects on improving motor function and activities of daily living in stroke patients. Transcutaneous vagus nerve stimulation appeared to be a potentially effective intervention, but further research is needed to confirm its relative superiority.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Clinical Neurology
Philippe Vignaud, Ondine Adam, Ulrich Palm, Chris Baeken, Nathalie Prieto, Emmanuel Poulet, Jerome Brunelin
Summary: This article systematically reviews previous studies on the effect of non-invasive brain stimulation (NIBS) on stress-induced cortisol release. Results suggest that stimulating the left dorsolateral prefrontal cortex may be the most efficient method for reducing cortisol release in acute stress situations.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Giorgia G. Evangelista, Philip Egger, Julia Bruegger, Elena Beanato, Philipp J. Koch, Martino Ceroni, Lisa Fleury, Andeol Cadic-Melchior, Nathalie H. Meyer, Diego de Leon Rodriguez, Gabriel Girard, Bertrand Leger, Jean-Luc Turlan, Andreas Muehl, Philippe Vuadens, Jan Adolphsen, Caroline E. Jagella, Christophe Constantin, Vincent Alvarez, Diego San Millan, Christophe Bonvin, Takuya Morishita, Maximilian J. Wessel, Dimitri Van De Ville, Friedhelm C. Hummel
Summary: This study investigates the correlation between brain network connectivity and deficits in different domains in stroke patients. It finds that attentional deficits are more sensitive to disruption of coordinated networks, while motor deficits are more sensitive to disruption of localized networks. This study is of great importance for understanding stroke mechanisms.
Article
Multidisciplinary Sciences
Diego Milardovich, Victor H. Souza, Ivan Zubarev, Sergei Tugin, Jaakko O. Nieminen, Claudia Bigoni, Friedhelm C. Hummel, Juuso T. Korhonen, Dogu B. Aydogan, Pantelis Lioumis, Nima Taherinejad, Tibor Grasser, Risto J. Ilmoniemi
Summary: The study developed a deep learning-based algorithm, DELMEP, to automate the estimation of motor evoked potentials (MEPs) latency. The algorithm has low computational cost, allowing real-time MEP characterization, and shows high accuracy. This makes it a promising option for artificial intelligence-based personalized clinical applications.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Theresa Paul, Valerie M. Wiemer, Lukas Hensel, Matthew Cieslak, Caroline Tscherpel, Christian Grefkes, Scott T. Grafton, Gereon R. Fink, Lukas J. Volz
Summary: This study used diffusion spectrum imaging (DSI) and a novel compartment-wise analysis approach to investigate the structural connectivity between bilateral cortical core motor regions in chronic stroke patients. The results showed that the structural connectivity between these regions is associated with both basal and complex motor control. Specifically, the recovery of basal motor control may be supported by an alternative pathway through the contralesional primary motor cortex (M1) and non-crossing fibers of the contralesional corticospinal tract (CST). These findings help explain conflicting interpretations of the functional role of the contralesional M1 and suggest the potential of cortico-cortical structural connectivity as a biomarker for motor recovery post-stroke.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Fabienne Windel, Remy Marc M. Gardier, Gaspard Fourchard, Roser Vinals, Daphne Bavelier, Frank Johannes Padberg, Elmars Rancans, Omer Bonne, Mor Nahum, Jean-Philippe Thiran, Takuya Morishita, Friedhelm Christoph Hummel
Summary: This study introduces an easy-to-use digital tool to support patients for self-application of non-invasive brain stimulation (NIBS) at home. The results demonstrate that the tool improves accuracy of electrode placement and provides positive user experience. This research supports the feasibility of correct NIBS self-application in home-based settings.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
Maximilian J. Wessel, Elena Beanato, Traian Popa, Fabienne Windel, Pierre Vassiliadis, Pauline Menoud, Valeriia Beliaeva, Ines R. Violante, Hedjoudje Abderrahmane, Patrycja Dzialecka, Chang-Hyun Park, Pablo Maceira-Elvira, Takuya Morishita, Antonino M. Cassara, Melanie Steiner, Nir Grossman, Esra Neufeld, Friedhelm C. Hummel
Summary: This study demonstrates the successful noninvasive neuromodulation of the striatum using tTIS, which enhances motor performance by increasing activity in the striatum and associated motor network. This has important implications for understanding the functional role of deep brain structures and developing noninvasive treatment strategies for brain disorders related to these structures.
NATURE NEUROSCIENCE
(2023)
Article
Medicine, Research & Experimental
Claudia Bigoni, Elena Beanato, Sylvain Harquel, Julie Herve, Meltem Oflar, Andrea Crema, Arnau Espinosa, Giorgia G. Evangelista, Philipp Koch, Christophe Bonvin, Jean-Luc Turlan, Adrian Guggisberg, Takuya Morishita, Maximilian J. Wessel, Sarah B. Zandvliet, Friedhelm C. Hummel
Summary: This study aims to improve upper-limb impairment in stroke patients through a personalized-dosage cumulative intervention that combines various non-invasive neurotechnologies. The first patient in the study showed significant improvement in upper-limb movements and changes in brain structure and function. These promising results suggest the feasibility, safety, and potential efficacy of this personalized approach, and integrating multi-modal data may provide predictive information regarding treatment response and outcomes.
Article
Clinical Neurology
Simone Rossi, Alessandra Cinti, Francesca Viberti, Alberto Benelli, Francesco Neri, David De Monte, Alessandro Giannotta, Sara Romanella, Carmelo Smeralda, Aniello Donniacuo, Domenico Prattichizzo, Patrizio Pasqualetti, Emiliano Santarnecchi, Marco Mandala
Summary: This study investigated the effects of biophysically modeled transcranial oscillatory current stimulation (tACS) on the vestibular cortex. Results showed that 1Hz and 2Hz tACS induced motion sickness, oscillopsia, and postural instability, while 10Hz tACS had no effect on vestibular function. These findings suggest that weak electrical oscillations in the frequency range corresponding to the physiological cortical activity of the vestibular system can generate motion sickness and postural sways. This new side effect of tACS should be considered in future studies on cognitive functions.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neuroimaging
Janusz L. Koob, Shivakumar Viswanathan, Maike Mustin, Imon Mallick, Sebastian Krick, Gereon R. Fink, Christian Grefkes, Anne K. Rehme
Summary: This study aims to investigate the factors in the early post-acute stage that may increase the risk of depression symptoms in stroke patients. The results show that more severe motor impairment promotes reward-dependent motor engagement, while depression and corticostriatal lesions may disrupt incentive motivational behavior, thereby increasing the risk of chronic depressive symptoms.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
M. J. Wessel, L. R. Draaisma, M. Durand-Ruel, P. Maceira-Elvira, M. Moyne, J. -l. Turlan, A. Muhl, L. Chauvigne, P. J. Koch, T. Morishita, A. G. Guggisberg, F. C. Hummel
Summary: Impairment of hand motor function is common after a stroke and affects the ability to regain independent living. Combining behavioral training and non-invasive brain stimulation of the motor cortex can improve motor deficits. This study tested a novel approach by targeting the cortico-cerebellar system during learning. The application of this targeted stimulation strategy enhanced motor behavior during the early training phase in stroke survivors.
Article
Clinical Neurology
Jaakko Vallinoja, Timo Nurmi, Julia Jaatela, Vincent Wens, Mathieu Bourguignon, Helena Maenpaa, Harri Piitulainen
Summary: The study aimed to assess the effects of lesions related to spastic diplegic cerebral palsy on functional connectivity. Using multiple imaging modalities, the researchers found enhanced functional connectivity in the sensorimotor network of individuals with spastic diplegic cerebral palsy, which was not correlated with hand coordination performance.
CLINICAL NEUROPHYSIOLOGY
(2024)
Article
Clinical Neurology
Francesca Ginatempo, Nicola Loi, John C. Rothwell, Franca Deriu
Summary: This study comprehensively investigated sensorimotor integration in the cranial-cervical muscles of healthy adults and found that the integration of sensory inputs with motor output is profoundly influenced by the type of sensory afferent involved and the functional role played by the target muscle.
CLINICAL NEUROPHYSIOLOGY
(2024)
