Article
Orthopedics
Devon R. Ackerman, Anna M. Ptasinski, Travis Edmond, Mark L. Dunleavy, Robert A. Gallo
Summary: A study found that NFL offensive linemen who wear prophylactic knee braces have a lower risk of major knee injury without a significant difference in performance compared to those who do not wear the braces. However, the prevalence of brace usage has declined over the study period.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2023)
Review
Clinical Neurology
Lauren P. Giesler, Richelle Mychasiuk, Sandy R. Shultz, Stuart J. McDonald
Summary: Traumatic brain injury is a common health problem that affects millions of people every year. The Val66Met single-nucleotide polymorphism in BDNF has been studied for its impact on traumatic brain injury outcomes and its role in brain homeostasis. This review examines animal models and clinical studies investigating the effects of Val66Met on cognitive function, motor function, neuropsychiatric symptoms, and nociception in traumatic brain injury. It also reviews studies on the pathophysiology of traumatic brain injury and the use of circulating BDNF as a biomarker.
Article
Critical Care Medicine
Prajwal Ciryam, Volodymyr Gerzanich, J. Marc Simard
Summary: Traumatic brain injury (TBI) is a common and devastating illness with significant public health implications. Current treatments do not effectively target the immune response associated with injury, which is mediated in part by disruptions in the blood-brain barrier. Interleukin-6 (IL-6) is a key player in this immune response and understanding its role in TBI could help in developing targeted therapies.
JOURNAL OF NEUROTRAUMA
(2023)
Review
Cell Biology
Qing-Sheng Li, Yan-Jie Jia
Summary: Ferroptosis is a new form of programmed cell death that is not necrotic and is caused by iron-dependent phospholipid peroxidation. It plays a key role in secondary traumatic brain injury and secondary spinal cord injury and is closely related to inflammation, immunity, and chronic injuries. Inhibitors against ferroptosis effectively improve iron homeostasis, lipid metabolism, redox stabilization, neuronal remodeling, and functional recovery after trauma. This review elaborates on the latest molecular mechanisms of ferroptosis, emphasizes its role in secondary central nervous trauma, and updates the medicines used to suppress ferroptosis following injuries.
NEURAL REGENERATION RESEARCH
(2023)
Article
Critical Care Medicine
Timothy M. Guenther, Marguerite W. Spruce, Lindsey M. Bach, Connor M. Caples, Carl A. Beyer, John K. Grayson, Frederick J. Meyers, Tina L. Palmieri, Ian E. Brown
Summary: The study found that both restrictive and aggressive resuscitation strategies showed adequate resuscitation results at 8 hours post-injury in treating combined burn and traumatic brain injury. An increase in serum blood urea nitrogen (BUN) in the restrictive resuscitation group may indicate early acute kidney injury, despite adequate urine output. Resuscitation strategy did not appear to have an impact on intracranial pressure or the size of brain injury.
Review
Neurosciences
Omid Mohamadzadeh, Mahsasadat Hajinouri, Farzaneh Moammer, Seyed Saeed Tamehri Zadeh, Ghoncheh Omid Shafiei, Ameneh Jafari, Amirreza Ostadian, Sayyed Alireza Talaei Zavareh, Michael R. Hamblin, Arezoo Jafarian Yazdi, Amirhossein Sheida, Hamed Mirzaei
Summary: Nowadays, traumatic brain injury (TBI) is a global concern due to its significant morbidity and long-term consequences that are not fully understood. Cellular pathways such as free radical production, excitotoxicity, apoptosis, and neuroinflammatory responses have been identified in TBI. Non-coding RNAs (ncRNAs) have been found to play a crucial role in post-transcriptional regulation in the brain, and altered levels of ncRNA expression have been observed in both traumatic and non-traumatic brain injuries. This review provides an overview of the primary molecular mechanisms involved in TBI and discusses the latest findings on changes and the role of ncRNAs in TBI from both clinical and experimental research.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Cyrus Ayubcha, Mona-Elisabeth Revheim, Andrew Newberg, Mateen Moghbel, Chaitanya Rojulpote, Thomas J. Werner, Abass Alavi
Summary: PET has been widely used in the study of traumatic brain injury (TBI) for decades, with recent focus on imaging biomarkers related to TBI and chronic traumatic encephalopathy (CTE). This review critically assesses the use of glycolysis, beta-amyloid, and tau protein radiotracers in the context of TBI, weighing their strengths and weaknesses. Despite the ongoing debate, PET remains a powerful modality in diagnosing TBI-related conditions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Biotechnology & Applied Microbiology
Jared A. Rifkin, Taotao Wu, Adam C. Rayfield, Erin D. Anderson, Matthew B. Panzer, David F. Meaney
Summary: Research on data from the Human Connectome Project (HCP) reveals similar brain architecture groups in both men and women, with some architectures being more vulnerable to traumatic brain injuries (TBI).
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Neurosciences
Mecca B. A. R. Islam, Booker T. Davis IV, Mary J. Kando, Qinwen Mao, Daniele Procissi, Craig Weiss, Steven J. Schwulst
Summary: The study found that young adult mice showed more severe neuropathology and greater loss of white matter connectivity after TBI compared to aged mice. Differential functional outcomes were also observed in anxiety response, learning, and memory between young adult and aged mice after TBI.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chiara Mele, Valeria Pingue, Marina Caputo, Marco Zavattaro, Loredana Pagano, Flavia Prodam, Antonio Nardone, Gianluca Aimaretti, Paolo Marzullo
Summary: The incidence of traumatic brain injury (TBI) has been increasing, impacting public health. Research indicates that post-TBI neuroinflammation may lead to long-term clinical consequences, such as hypopituitarism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Clinical Neurology
William P. Flavin, Helia Hosseini, Jeffrey W. Ruberti, H. Pirouz Kavehpour, Christopher C. Giza, Mayumi L. Prins
Summary: This review summarizes the structure and functions of Tau protein, highlighting its associations with various diseases and conditions including diabetes, stroke, Alzheimer's disease, brain injury, aging, and drug use. It explores the role of Tau phosphorylation in disease progression and discusses the potential for therapeutic interventions to prevent or reverse tau-mediated neurodegeneration.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Michael C. Scott, Karthik S. Prabhakara, Andrew J. Walters, Scott D. Olson, Charles S. Cox
Summary: In a rodent model of traumatic brain injury, sex-based differences in pathology and neuroinflammation are limited, and only noted in one specific analysis of BBB permeability.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Peter J. Hutchinson, Hadie Adams, Midhun Mohan, Bhagavatula I. Devi, Christopher Uff, Shumaila Hasan, Harry Mee, Mark H. Wilson, Deepak K. Gupta, Diederik Bulters, Ardalan Zolnourian, Catherine J. McMahon, Matthew G. Stovell, Yahia Z. Al-Tamimi, Manoj K. Tewari, Manjul Tripathi, Simon Thomson, Edoardo Viaroli, Antonio Belli, Andrew T. King, Adel E. Helmy, Ivan S. Timofeev, Sarah Pyne, Dhaval P. Shukla, Dhananjaya I. Bhat, Andrew R. Maas, Franco Servadei, Geoffrey T. Manley, Garry Barton, Carole Turner, David K. Menon, Barbara Gregson, Angelos G. Kolias
Summary: Patients with traumatic acute subdural hematomas often require either craniotomy or decompressive craniectomy for surgical evacuation. The study shows that the disability and quality-of-life outcomes are similar with both approaches. However, additional surgery was more common in the craniotomy group and more wound complications occurred in the craniectomy group.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Neurosciences
Sarah E. Svirsky, Youming Li, Jeremy Henchir, Anna Rodina, Shaun W. Carlson, Gabriela Chiosis, C. Edward Dixon
Summary: This study investigates the formation of the epichaperome in traumatic brain injury (TBI) and suggests that this mechanism may contribute to protein misfolding, degradation, aggregation, and transport. Further understanding of this pathological mechanism can provide insights into the connection between TBI and increased risk of neurodegenerative diseases, as well as potential therapeutic targets.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Neurosciences
Hazem S. Ghaith, Asmaa Ahmed Nawar, Mohamed Diaa Gabra, Mohamed Essam Abdelrahman, Mohamed H. Nafady, Eshak Bahbah, Mahmoud Ahmed Ebada, Ghulam Md Ashraf, Ahmed Negida, George E. Barreto
Summary: Research into TBI biomarkers has accelerated in the past decade, but there is still a need to develop novel biomarkers entirely correlating with TBI pathologies; extracellular vesicles and miRNA are considered as promising candidates to overcome the limitations of traditional blood and CSF assays.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Orthopedics
Farzana Ansari, Taylor Lee, Louis Malito, Audrey Martin, Stephen B. Gunther, Samuel Harmsen, Tom R. Norris, Mike Ries, Douglas Van Citters, Lisa Pruitt
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2016)
Article
Neuroimaging
Sumra Bari, Diana O. Svaldi, Ikbeom Jang, Trey E. Shenk, Victoria N. Poole, Taylor Lee, Ulrike Dydak, Joseph V. Rispoli, Eric A. Nauman, Thomas M. Talavage
BRAIN IMAGING AND BEHAVIOR
(2019)
Article
Neuroimaging
Ikbeom Jang, Il Yong Chun, Jared R. Brosch, Sumra Bari, Yukai Zou, Brian R. Cummiskey, Taylor A. Lee, Roy J. Lycke, Victoria N. Poole, Trey E. Shenk, Diana O. Svaldi, Gregory G. Tamer, Ulrike Dydak, Larry J. Leverenz, Eric A. Nauman, Thomas M. Talavage
NEUROIMAGE-CLINICAL
(2019)
Article
Biophysics
Nicolas Leiva-Molano, Robert J. Rolley, Taylor Lee, Kevin G. McIver, Goutham Sankaran, Janette J. Meyer, Douglas E. Adams, Evan Breedlove, Thomas M. Talavage, Eric A. Nauman
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME
(2020)
Article
Biochemical Research Methods
Ho-Ching (Shawn) Yang, Zhenhu Liang, Nicole L. Vike, Taylor Lee, Joseph Rispoli, Eric A. Nauman, Thomas M. Talavage, Yunjie Tong
JOURNAL OF BIOPHOTONICS
(2020)
Article
Engineering, Biomedical
Taylor Lee, Roy Lycke, Joshua Auger, Jacob Music, Michael Dziekan, Sharlene Newman, Thomas Talavage, Larry Leverenz, Eric Nauman
Summary: The study aimed to evaluate the impact of repetitive head traumas on athletes in contact sports, finding that the type of sport has a greater influence on head acceleration event characteristics than the level of play.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE
(2021)