4.7 Editorial Material

Favipiravir and Zanamivir Cleared Infection with Influenza B in a Severely Immunocompromised Child

Journal

CLINICAL INFECTIOUS DISEASES
Volume 71, Issue 7, Pages E191-E194

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/cid/ciaa023

Keywords

influenza; favipiravir; zanamivir; genome sequencing

Funding

  1. Sir Henry Dale Fellowship - Wellcome Trust [101239/Z/13/Z, 101239/Z/13/A]
  2. Sir Henry Dale Fellowship - Royal Society [101239/Z/13/Z, 101239/Z/13/A]
  3. Wellcome Trust Studentship [105365/Z/14/Z]
  4. UCL/UCLH NIHR Biomedical Research Centre
  5. Isaac Newton Trust
  6. Wellcome Trust [101239/Z/13/A, 105365/Z/14/Z] Funding Source: Wellcome Trust

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A combination of favipiravir and zanamivir successfully cleared influenza B infection in a child who had undergone bone marrow transplant for X-linked severe combined immunodeficiency, with no recovery of T lymphocytes. Deep sequencing of viral samples illuminated the within-host dynamics of infection, demonstrating the effectiveness of favipiravir in this case.

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