Genetic and epigenetic regulation of abdominal aortic aneurysms

Long noncoding RNAs in vascular smooth muscle cells regulate vascular calcification

(2019) Geon Jeong et al.   Scientific Reports

Epigenetic regulation of regulatory T cells in patients with abdominal aortic aneurysm

(2019) Qian Xia et al.   FEBS Open Bio

LncRNA H19 promotes vascular inflammation and abdominal aortic aneurysm formation by functioning as a competing endogenous RNA

(2019) Yili Sun et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Epigenetics and vascular diseases

(2019) Matthew S. Stratton et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sex differences in abdominal aortic aneurysms

(2018) Austin C. Boese et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

H19 Induces Abdominal Aortic Aneurysm Development and Progression

(2018) Daniel Y. Li et al.   CIRCULATION

A mutation update on the LDS-associated genes TGFB2/3 and SMAD2/3

(2018) Dorien Schepers et al.   HUMAN MUTATION

Intraluminal thrombus is associated with early rupture of abdominal aortic aneurysm

(2018) Stephen J. Haller et al.   JOURNAL OF VASCULAR SURGERY

On the influence of wall calcification and intraluminal thrombus on prediction of abdominal aortic aneurysm rupture

(2018) Hilary E. Barrett et al.   JOURNAL OF VASCULAR SURGERY

Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation

(2018) Michael J. Thomenius et al.   PLoS One

Should Abdominal Aortic Aneurysms in Women be Repaired at a Lower Diameter Threshold?

(2018) Sarah E. Deery et al.   Vascular and Endovascular Surgery

SMYD2 promoter DNA methylation is associated with abdominal aortic aneurysm (AAA) and SMYD2 expression in vascular smooth muscle cells

(2018) Bradley J. Toghill et al.   Clinical Epigenetics

Long noncoding RNA NEAT1 (nuclear paraspeckle assembly transcript 1) is critical for phenotypic switching of vascular smooth muscle cells

(2018) Abu Shufian Ishtiaq Ahmed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tobacco smoking and the risk of abdominal aortic aneurysm: a systematic review and meta-analysis of prospective studies

(2018) Dagfinn Aune et al.   Scientific Reports

Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

(2018) Tarik Hadi et al.   Nature Communications

Risk Factors for Abdominal Aortic Aneurysm in Population-Based Studies: A Systematic Review and Meta-Analysis

(2018) Emma Altobelli et al.   International Journal of Environmental Research and Public Health

Abdominal aortic aneurysms

(2018) Natzi Sakalihasan et al.   Nature Reviews Disease Primers

The lysine methyltransferase SMYD2 methylates the kinase domain of type II receptor BMPR2 and stimulates bone morphogenetic protein signaling

(2017) Shuman Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The long non-coding RNA GAS5 regulates transforming growth factor β (TGF-β)–induced smooth muscle cell differentiation via RNA Smad–binding elements

(2017) Rui Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A current view on contactin-4, -5, and -6: Implications in neurodevelopmental disorders

(2017) Asami Oguro-Ando et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Risk of abdominal aortic aneurysm (AAA) among male and female relatives of AAA patients

(2017) Koen M van de Luijtgaarden et al.   VASCULAR MEDICINE

Non-coding RNA Contribution to Thoracic and Abdominal Aortic Aneurysm Disease Development and Progression

(2017) Yuhuang Li et al.   Frontiers in Physiology

The role of IL-6 in pathogenesis of abdominal aortic aneurysm in mice

(2017) Michihide Nishihara et al.   PLoS One

MYOSLIDIs a Novel Serum Response Factor–Dependent Long Noncoding RNA That Amplifies the Vascular Smooth Muscle Differentiation ProgramHighlights

(2016) Jinjing Zhao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Smooth Muscle Enriched Long Noncoding RNA (SMILR) Regulates Cell ProliferationCLINICAL PERSPECTIVE

(2016) Margaret D. Ballantyne et al.   CIRCULATION

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk LociNovelty and Significance

(2016) Gregory T. Jones et al.   CIRCULATION RESEARCH

MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and ElastinNovelty and Significance

(2016) Karina Di Gregoli et al.   CIRCULATION RESEARCH

Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors

(2016) María Galán et al.   Disease Models & Mechanisms

Editor's Choice – High Heritability of Liability to Abdominal Aortic Aneurysms: A Population Based Twin Study

(2016) T.M.M. Joergensen et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Marfan Syndrome and Related Disorders: 25 Years of Gene Discovery

(2016) Aline Verstraeten et al.   HUMAN MUTATION

Thresholds for Abdominal Aortic Aneurysm Repair in England and the United States

(2016) Alan Karthikesalingam et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG

(2016) Aarti V. Shah et al.   VASCULAR PHARMACOLOGY

The Sp1-mediaded allelic regulation of MMP13 expression by an ESCC susceptibility SNP rs2252070

(2016) Meng Shi et al.   Scientific Reports

Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm

(2016) Yanshuo Han et al.   Clinical Epigenetics

The potential role of DNA methylation in the pathogenesis of abdominal aortic aneurysm

(2015) Bradley J. Toghill et al.   ATHEROSCLEROSIS

Mechanisms of regulation of mature miRNAs

(2015) B. P. Towler et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Architectural and Functional Commonalities between Enhancers and Promoters

(2015) Tae-Kyung Kim et al.   CELL

Association between polymorphisms in the interleukin-10 gene and risk of abdominal aortic aneurysm

(2015) F. Wang et al.   GENETICS AND MOLECULAR RESEARCH

Transcriptional (ChIP-Chip) Analysis of ELF1, ETS2, RUNX1 and STAT5 in Human Abdominal Aortic Aneurysm

(2015) Matthew Pahl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Histone Methyltransferase Smyd2 Is a Negative Regulator of Macrophage Activation by Suppressing Interleukin 6 (IL-6) and Tumor Necrosis Factor α (TNF-α) Production

(2015) Guiliang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Abnormal Epigenetic Modifications in Peripheral T Cells from Patients with Abdominal Aortic Aneurysm Are Correlated with Disease Development

(2015) Han Jiang et al.   JOURNAL OF VASCULAR RESEARCH

Association of rs1466535 LRP1 but not rs3019885 SLC30A8 and rs6674171 TDRD10 gene polymorphisms with abdominal aortic aneurysm in Italian patients

(2015) Silvia Galora et al.   JOURNAL OF VASCULAR SURGERY

Regulatory MicroRNA Networks: Complex Patterns of Target Pathways for Disease-related and Housekeeping MicroRNAs

(2015) Sachli Zafari et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

SMYD Proteins: Key Regulators in Skeletal and Cardiac Muscle Development and Function

(2014) Shao Jun Du et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Low-Density Lipoprotein Receptor–Related Protein-1

(2014) Dudley K. Strickland et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification and Initial Functional Characterization of a Human Vascular Cell–Enriched Long Noncoding RNA

(2014) Robert D. Bell et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Prevention of Abdominal Aortic Aneurysm by Anti-MicroRNA-712 or Anti-MicroRNA-205 in Angiotensin II-Infused Mice

(2014) C. W. Kim et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Aortopathy in Marfan syndrome: an update

(2014) Federico Romaniello et al.   CARDIOVASCULAR PATHOLOGY

Role of miR-195 in Aortic Aneurysmal Disease

(2014) Anna Zampetaki et al.   CIRCULATION RESEARCH

Relative importance of aneurysm diameter and body size for predicting abdominal aortic aneurysm rupture in men and women

(2014) Ruby C. Lo et al.   JOURNAL OF VASCULAR SURGERY

Epigenetics in the development, modification, and prevention of cardiovascular disease

(2014) Thomas F. Whayne   MOLECULAR BIOLOGY REPORTS

The revised role of TGF-β in aortic aneurysms in Marfan syndrome

(2014) R. Franken et al.   Netherlands Heart Journal

miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development

(2014) Lars Maegdefessel et al.   Nature Communications

LRP1 Protects the Vasculature by Regulating Levels of Connective Tissue Growth Factor and HtrA1

(2013) Selen C. Muratoglu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The potential role of homocysteine mediated DNA methylation and associated epigenetic changes in abdominal aortic aneurysm formation

(2013) Smriti Murali Krishna et al.   ATHEROSCLEROSIS

The role of transforming growth factor-beta in Marfan syndrome

(2013) Kálmán Benke et al.   Cardiology Journal

Novel Long Noncoding RNAs Are Regulated by Angiotensin II in Vascular Smooth Muscle Cells

(2013) Amy Leung et al.   CIRCULATION RESEARCH

A Variant in LDLR Is Associated With Abdominal Aortic Aneurysm

(2013) Declan T. Bradley et al.   Circulation-Cardiovascular Genetics

ETS Factors Regulate Vegf-Dependent Arterial Specification

(2013) Joshua D. Wythe et al.   DEVELOPMENTAL CELL

A Pilot Study on Low-density Lipoprotein Receptor-related Protein-1 in Chinese Patients with Abdominal Aortic Aneurysm

(2013) C.Y.T. Chan et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

SMYD2 is induced during cell differentiation and participates in early development

(2013) Borja Sesé et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Gender differences in abdominal aortic aneurysm presentation, repair, and mortality in the Vascular Study Group of New England

(2013) Ruby C. Lo et al.   JOURNAL OF VASCULAR SURGERY

MicroRNA-29b regulation of abdominal aortic aneurysm development

(2013) Lars Maegdefessel et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Hyperhomocysteinemia Exaggerates Adventitial Inflammation and Angiotensin II−Induced Abdominal Aortic Aneurysm in Mice

(2012) Ziyi Liu et al.   CIRCULATION RESEARCH

Interleukin-6 receptor pathways in abdominal aortic aneurysm

(2012) Seamus C. Harrison et al.   EUROPEAN HEART JOURNAL

Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization

(2012) L. T. Donlin et al.   GENES & DEVELOPMENT

Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells

(2012) A. Motterle et al.   HUMAN MOLECULAR GENETICS

Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development

(2012) Lars Maegdefessel et al.   JOURNAL OF CLINICAL INVESTIGATION

A meta-analysis of outcomes of endovascular abdominal aortic aneurysm repair in patients with hostile and friendly neck anatomy

(2012) George A. Antoniou et al.   JOURNAL OF VASCULAR SURGERY

Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1

(2011) Matthew J. Bown et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Role of vascular endothelial growth factor-A in development of abdominal aortic aneurysm

(2011) Hidehiro Kaneko et al.   CARDIOVASCULAR RESEARCH

MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation

(2011) Reinier A. Boon et al.   CIRCULATION RESEARCH

miR-143 and miR-145

(2011) Ashraf Yusuf Rangrez et al.   Circulation-Cardiovascular Genetics

OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases

(2011) Ku-Chung Chen et al.   FASEB JOURNAL

Polymorphisms of genes involved in extracellular matrix remodeling and abdominal aortic aneurysm

(2011) Claudia Saracini et al.   JOURNAL OF VASCULAR SURGERY

Fibroblast growth factor 9 delivery during angiogenesis produces durable, vasoresponsive microvessels wrapped by smooth muscle cells

(2011) Matthew J Frontini et al.   NATURE BIOTECHNOLOGY

Genes and Abdominal Aortic Aneurysm

(2010) Irene Hinterseher et al.   ANNALS OF VASCULAR SURGERY

Deficient CD4 + CD25 + T Regulatory Cell Function in Patients With Abdominal Aortic Aneurysms

(2010) Mingdi Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Atherosclerosis in Abdominal Aortic Aneurysms: A Causal Event or a Process Running in Parallel? The Tromsø Study

(2010) Stein Harald Johnsen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm

(2010) Solveig Gretarsdottir et al.   NATURE GENETICS

Pathophysiology and epidemiology of abdominal aortic aneurysms

(2010) Ian M. Nordon et al.   Nature Reviews Cardiology

Allele-Specific Regulation of Matrix Metalloproteinase-3 Gene by Transcription Factor NFκB

(2010) Veronika Souslova et al.   PLoS One

The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules

(2010) S. Bouyain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

A Necessary Role of miR-221 and miR-222 in Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia

(2009) Xiaojun Liu et al.   CIRCULATION RESEARCH

Inherited diseases and syndromes leading to aortic aneurysms and dissections

(2009) Ahmet Okay Caglayan et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Identification of a genetic variant associated with abdominal aortic aneurysms on chromosome 3p12.3 by genome wide association

(2009) James R. Elmore et al.   JOURNAL OF VASCULAR SURGERY

DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis

(2009) D. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A common variant on chromosome 9p21 affects the risk of early-onset coronary artery disease

(2008) Zhong Chen et al.   MOLECULAR BIOLOGY REPORTS

The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm

(2008) Anna Helgadottir et al.   NATURE GENETICS

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

(2008) Cristen J Willer et al.   NATURE GENETICS

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

(2008) Yurii S Aulchenko et al.   NATURE GENETICS

Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease

(2007) Joseph D. Raffetto et al.   BIOCHEMICAL PHARMACOLOGY