Article
Genetics & Heredity
Huixia Wu, Jianfang Che, Wei Zheng, Dehua Cheng, Fei Gong, Guangxiu Lu, Ge Lin, Can Dai
Summary: Fertilization of the egg by the sperm is a vital stage of embryogenesis, but polyspermy, which is the entry of multiple sperm into the egg, is generally lethal to the embryo. A recent study identified a gene variant in ASTL that is associated with female infertility characterized by polyspermy. This study further expands the understanding of ASTL mutations and can aid in the diagnosis of oocyte-borne polyspermy.
Article
Genetics & Heredity
Yanwei Sha, Wensheng Liu, Xiaoli Wei, Xingshen Zhu, Bowen Tang, Xiaoya Zhang, Xiaoyu Yang, Yifeng Wang, Xiong Wang
Summary: The study identified ATG4D as a novel candidate gene associated with non-obstructive azoospermia (NOA) and suggested that autophagy-related cysteine peptidase family genes may play crucial roles in human spermatogenesis.
Review
Oncology
Laila Belcaid, Birgitte Bertelsen, Karin Wadt, Ida Tuxen, Iben Spanggaard, Martin Hojgaard, Jens Benn Sorensen, Jesper Ravn, Ulrik Lassen, Finn Cilius Nielsen, Kristoffer Rohrberg, Christina Westmose Yde
Summary: This study identified a high frequency of germline pathogenic variants in patients with mesothelioma. These variants are associated with DNA repair pathways, suggesting the potential of targeting DNA repair pathways for mesothelioma treatment.
Article
Obstetrics & Gynecology
Eliza C. C. Curnow, Bianca Vannucci, Charles H. H. Muller, Christopher N. N. Herndon
Summary: We report a rare case of successful live birth after assisted oocyte activation of failed fertilized oocytes. A woman with multi-factor infertility underwent in vitro fertilization (IVF) using intracytoplasmic sperm injection (ICSI) of frozen/thawed testicular sperm aspiration (TESA) sample. The oocytes showed failed fertilization, but the cycle was rescued using an assisted oocyte activation (AOA) protocol. One genetically normal embryo resulting from the AOA was transferred and led to a normal pregnancy and live birth.
REPRODUCTIVE SCIENCES
(2023)
Article
Physiology
Zhenteng Liu, Jianxiang Cong, Xuemei Liu, Huishan Zhao, Shoucui Lai, Shunzhi He, Hongchu Bao
Summary: This study evaluates the impact of dyslipidemia on the cumulative live-birth rate in non-PCOS patients undergoing IVF cycles. Results indicate that patients with dyslipidemia require more gonadotrophins for ovarian stimulation, have fewer retrieved oocytes, and lower live-birth rates. Adjusted multivariate logistic regression analysis shows a negative association between dyslipidemia and cumulative live-birth rate.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Wei Liu, Tongye Sha, Yuzhen Huang, Zizhen Guo, Lei Yan, Jinlong Ma
Summary: This study aimed to predict the live birth rate in infertile women with a history of ovarian cystectomy for endometriomas after IVF/ICSI-ET cycles. The results showed that female age, BMI, AFC, and number of embryos transferred were important factors affecting the live birth rate.
FRONTIERS IN MEDICINE
(2021)
Article
Endocrinology & Metabolism
Xiaokun Hu, Yuliang Liu, Xiubing Zhang, Pingyin Lee, Yangxing Wen, Chenhui Ding, Canquan Zhou, Yanwen Xu
Summary: This study aimed to investigate the impact of oocyte degeneration after ICSI on cumulative live birth rate in young women; The results showed that oocyte degeneration is not an indicator for predicting the cumulative live birth rate.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Enqi Yan, Wenxuan Li, Huizi Jin, Mengya Zhao, Dan Chen, Xinyao Hu, Yifan Chu, Yaxin Guo, Lei Jin
Summary: The aim of this study was to describe the cumulative live birth rates (CLBRs) of young women with or without low prognosis according to the POSEIDON criteria after IVF/ICSI cycles and to investigate whether the diagnosis of low prognosis increases the risk of abnormal birth outcomes. The study found that the CLBRs in the POSEIDON group were lower than the non-POSEIDON group, but the risk of abnormal birth outcomes did not increase in the POSEIDON group.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
David J. McLernon, Edwin-Amalraj Raja, James P. Toner, Valerie L. Baker, Kevin J. Doody, David B. Seifer, Amy E. Sparks, Ethan Wantman, Paul C. Lin, Siladitya Bhattacharya, Bradley J. Van Voorhis
Summary: This study aims to develop in vitro fertilization (IVF) prediction models to estimate individualized chances of cumulative live birth, providing guidance for IVF treatment at different time points.
FERTILITY AND STERILITY
(2022)
Article
Genetics & Heredity
Phillip A. Romanski, Pietro Bortoletto, Brady Magaoay, Alice Chung, Zev Rosenwaks, Steven D. Spandorfer
Summary: The study evaluated the impact of class III and class IV obesity on clinical outcomes after the first oocyte retrieval and fresh embryo transfer cycle. It found that patients with a BMI > 40 had worse IVF treatment outcomes compared to normal-weight patients, with higher rates of cancelled fresh transfers, increased miscarriage rates, and higher c-section rates for singleton deliveries.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Obstetrics & Gynecology
M. Mignini Renzini, M. Dal Canto, M. C. Guglielmo, D. Garcia, E. De Ponti, A. La Marca, R. Vassena, J. Buratini
Summary: Sperm donation increases live birth rates in AMA patients undergoing ICSI cycles, with a significant difference observed in live birth and miscarriage rates compared to homologous cycles. This suggests that sperm donation may be a valuable strategy to improve ICSI outcomes in AMA patients.
HUMAN REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Diane De Neubourg, Kris Bogaerts, Elisabeth Anagnostou, Candice Autin, Christophe Blockeel, Tom Coetsier, Anne Delbaere, Nicolas Gillain, Frank Vandekerckhove, Christine Wyns
Summary: The study observed that over six complete IVF/ICSI cycles, cumulative live birth rates were significantly higher in women under 35 years old, while multiple live birth rates decreased when comparing the periods of 2014-2017 and 2009-2012. Additionally, dropout rates increased during the 2014-2017 period compared to 2009-2012.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Biochemistry & Molecular Biology
Yichuan Liu, Hui-Qi Qu, Xiao Chang, Frank D. Mentch, Haijun Qiu, Xiang Wang, Amir Hossein Saeidian, Deborah Watson, Joseph Glessner, Hakon Hakonarson
Summary: Children with birth defects often have distinct clinical features and are predisposed to developing cancer. We performed a whole genome sequencing study and identified recurrent genetic variants associated with cancer development in these children. These variants were found in protein-coding and non-coding regions of the genome, including exons, introns, and ncRNAs.
Article
Endocrinology & Metabolism
Xiaoyun Gong, Yunian Zhang, Yuejie Zhu, Peng Wang, Zhihui Wang, Chen Liu, Manli Zhang, Xiaolin La
Summary: This study developed a nomogram based on POSEIDON criteria to predict live birth in patients with poor ovarian response. Age, BMI, AMH, normal fertilized oocytes, and basal FSH were identified as independent factors predicting live birth in these patients. The nomogram model showed good predictive accuracy in both the training and validation sets.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Chenyi Zhong, Liusijie Gao, Li Shu, Zhen Hou, Lingbo Cai, Jie Huang, Jiayin Liu, Yundong Mao
Summary: Endometriosis activity has a negative impact on the outcomes of IVF/ICSI cycles in patients with recurrent implantation failure (RIF). Patients with controlled endometriosis activity showed higher cumulative live birth rates, emphasizing the importance of medical treatment for improved prognosis in these patients.
FRONTIERS IN ENDOCRINOLOGY
(2021)
