Review
Medicine, Research & Experimental
Chyke A. Doubeni, Kevin Selby, Samir Gupta
Summary: Preventable differences in colorectal cancer mortality can be eliminated by assuring equitable access and quality across different groups. Multicomponent strategies, designed with a health equity framework, may be effective in addressing disparities. Effective strategies for increasing screening uptake include patient navigation, reminders, data tracking, and community engagement.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Article
Oncology
Desiree Schliemann, Kogila Ramanathan, Nor Saleha Binti Ibrahim Tamin, Ciaran O'Neill, Christopher R. Cardwell, Roshidi Ismail, Zaid Kassim, Frank Kee, Tin Tin Su, Michael Donnelly
Summary: The Colorectal Cancer Screening Intervention for Malaysia (CRC-SIM) was a study conducted to improve low screening uptake of colorectal cancer in Malaysia through home-based testing. The results showed that the home-based testing was acceptable and feasible in Malaysia, and it should be considered by public health planners.
Article
Oncology
Xuan Quy Luu, Kyeongmin Lee, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Kui Son Choi
Summary: This study investigated the long-term survival effects of colorectal cancer screening based on screening history and interval time since screening. The results showed that colorectal cancer screening was positively associated with favorable prognosis, especially among individuals screened within 1 year before diagnosis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Medicine, General & Internal
Zainab Aziz, Sophie Wagner, Alice Agyekum, Yoanna S. Pumpalova, Matthew Prest, Francesca Lim, Sheila Rustgi, Fay Kastrinos, William M. Grady, Chin Hur
Summary: Despite recommendations for universal screening, adherence to colorectal cancer screening in the US is low. This study evaluated the cost-effectiveness of liquid biopsy for colorectal cancer screening and found that colonoscopy was the most cost-effective strategy, while liquid biopsy was not cost-effective at its current cost and screening performance.
Article
Public, Environmental & Occupational Health
Silvia Portero de la Cruz, Jesus Cebrino
Summary: This study estimated the prevalence and evolution of uptake patterns to fecal immunochemical test (FIT) as a screening test for colorectal cancer (CRC) in Spain. The study found that 38.01% of participants had undergone FIT in the previous 2 years, and there was a significant increase in the uptake rate from 2017 to 2020. Factors such as age, education level, chronic illness, healthcare contact, alcohol consumption, and physical activity were positive predictors for FIT uptake pattern.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Oncology
Navkiran K. Shokar, Jennifer Salinas, Alok Dwivedi
Summary: This study utilized structural equation modeling to identify factors influencing participation in colorectal cancer screening among uninsured Hispanic individuals. The findings indicate that self-efficacy, perceived benefits, and fatalism significantly affect the effectiveness of screening interventions.
Article
Gastroenterology & Hepatology
Caitlin C. Murphy, Ethan A. Halm, Timothy Zaki, Carmen Johnson, Sruthi Yekkaluri, Lisa Quirk, Amit G. Singal
Summary: Background screening for colorectal cancer using fecal immunochemical testing (FIT) can reduce mortality, but rates remain low in underserved populations. Mailed outreach, including invitation letters and FIT testing, is an effective strategy to improve screening completion. In a safety-net healthcare system, about half of patients completed screening after receiving mailed invitations, with the majority completing FIT testing. However, many patients did not follow up with diagnostic colonoscopy after a positive FIT result.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Oncology
Gemma Ibanez-Sanz, Rebeca Sanz-Pamplona, Montse Garcia
Summary: Interval colorectal cancer serves as a measure of screening programme effectiveness, with further study into its epidemiological, clinical, and molecular characteristics providing insights for disease prevention.
Article
Public, Environmental & Occupational Health
Arlinda Ruco, Nancy N. Baxter, Jenna Jacobson, Jill Tinmouth, Diego Llovet
Summary: This study aimed to develop social media messages to promote colorectal cancer screening uptake. The findings suggest that Facebook users prefer messages with a positive or reassuring tone, educational content, and from credible sponsors. However, messages that use humor or a fearful tone may undermine campaign objectives.
Article
Pharmacology & Pharmacy
Gang Lv, Xiaoxia Wang, Xiangxiang Jiang, Minghui Li, Kevin Lu
Summary: This study examined the utilization, knowledge, and associated health disparities of colorectal cancer screening in older adults with Alzheimer's disease and related dementias. The results showed that ADRD was significantly associated with lower utilization of colorectal cancer screening and reduced knowledge about screening methods and Medicare coverage. Furthermore, the study identified health disparities in race/ethnicity, gender, and urban/rural residence in colorectal cancer screening use and knowledge.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Jennifer J. Brown, Charles K. Asumeng, David Greenwald, Matthew Weissman, Ann Zauber, Jared Striplin, Olivia Weng, Justin M. List, Shannon M. Farley, Sidney J. Winawer
Summary: A citywide campaign to increase screening colonoscopy was associated with decreased incidence and mortality rates among all ethnic/racial groups, but disparities still exist. Further interventions are needed to improve equity, especially for the Black population with higher CRC burden.
Article
Oncology
Ana R. Acuna-Villaorduna, Juan Lin, Mimi Kim, Sanjay Goel
Summary: Early-onset colorectal cancer is more common in Non-Hispanic Black and Hispanic populations, with differences in clinical/pathological features and cancer-specific survival compared to Non-Hispanic White populations.
Article
Public, Environmental & Occupational Health
Nuria Vives, Nuria Mila, Gemma Binefa, Noemie Travier, Albert Farre, Carmen Vidal, Maryam Sattari, Guillermo Bagaria, Montse Garcia
Summary: The study assessed the adherence of community pharmacies to the CRC screening program and analyzed data on FIT kit distribution and collection in the Metropolitan area of Barcelona (Catalonia, Spain). The findings highlight the large involvement of community pharmacists with CRC screening program as well as a high quality in the process of FIT distribution and collection.
PREVENTIVE MEDICINE
(2021)
Article
Oncology
Hyo Jung Tak, I-Wen Pan, Michael T. Halpern, Ya-Chen Tina Shih
Summary: The study found that the race-specific recommendation by the 2017 MSTF has a positive impact on colorectal cancer screening rates among young AAs, leading to a significant increase in screening rates for AAs which helps reduce cancer disparities among racial/ethnic minorities.
Article
Public, Environmental & Occupational Health
Benedicte Kirkoen, Paula Berstad, Geir Hoff, Tomm Bernklev, Kristin R. Randel, Oyvind Holme, Thomas de Lange, Kathryn A. Robb, Edoardo Botteri
Summary: This study examined the association between mental illness and colorectal cancer screening participation. The results showed that the use of psychotropic medications was associated with nonparticipation in screening, and the type and severity of mental illness also affected the participation rate. Targeted interventions are necessary to ensure that individuals with mental illness can access the benefits of colorectal cancer screening.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Robert J. Huang, Meira Epplein, Chisato Hamashima, Il Ju Choi, Eunjung Lee, Dennis Deapen, Yanghee Woo, Thuy Tran, Shailja C. Shah, John M. Inadomi, David A. Greenwald, Joo Ha Hwang
Summary: This study shows that the burden of GC is unequally distributed in the US, predominantly affecting Asian, African American, Hispanic, and American Indian/Alaskan Native populations. International studies have provided substantial evidence supporting the effectiveness of strategies such as H. pylori testing and treatment, as well as endoscopic screening in reducing GC-specific mortality. However, there is a lack of data from US sources. Therefore, there is an urgent need for cancer prevention trials targeting high-risk immigrant and minority populations in the US, and for the development of national strategies for GC prevention.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Amnon Sonnenberg, John M. Inadomi
Editorial Material
Gastroenterology & Hepatology
Sachin Wani, Rena Yadlapati, Siddharth Singh, Tarek Sawas, David A. Katzka, Matthew Hall, Jacques Bergman, Marcia I. Canto, Amitabh Chak, Douglas A. Corley, Gary W. Falk, Rebecca C. Fitzgerald, Rehan Haidry, John M. Inadomi, Prasad G. Iyer, Jennifer Kolb, Srinadh Komanduri, Vani Konda, Elizabeth A. Montgomery, V. Raman Muthusamy, Joel H. Rubenstein, Felice Schnoll-Sussman, Nicholas J. Shaheen, Michael Smith, Stuart Spechler, Ravy Vajravelu
Article
Public, Environmental & Occupational Health
Carolyn M. Rutter, John M. Inadomi, Christopher E. Maerzluft
Summary: Systematic delays in the screening process can significantly reduce the effectiveness of colorectal cancer screening, especially with longer delays. Screening delays may result in variations in colorectal cancer incidence among different patient groups.
JOURNAL OF MEDICAL SCREENING
(2022)
Article
Gastroenterology & Hepatology
Joel H. Rubenstein, Amir-Houshang Omidvari, Brianna N. Lauren, William D. Hazelton, Francesca Lim, Sarah Xinhui Tan, Chung Yin Kong, Minyi Lee, Ayman Ali, Chin Hur, John M. Inadomi, Georg Luebeck, Iris Lansdorp-Vogelaar
Summary: The optimal strategy for screening esophageal adenocarcinoma varies by race and sex. White men with GERD symptoms can potentially be screened more intensely than is currently recommended, while screening women may not be cost-effective and could even cause net harm for black women.
Editorial Material
Gastroenterology & Hepatology
John M. Inadomi
Article
Environmental Sciences
Charles R. Rogers, David G. Perdue, Kenneth Boucher, Kevin M. Korous, Ellen Brooks, Ethan Petersen, John M. Inadomi, Fa Tuuhetaufa, Ronald F. Levant, Electra D. Paskett
Summary: There is an association between masculinity barriers and lower rates of CRC screening completion, with negative attitudes towards medical professionals and exams as well as a strong masculine identity being significant factors. This association is more pronounced among Black men.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Meeting Abstract
Oncology
S. Hardikar, B. Krick, R. Benson, M. Winn, C. Winterton, P. A. Newcomb, J. M. Inadomi, C. M. Ulrich
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Ming Yu, Helen R. Moinova, Amber Willbanks, Victoria K. Cannon, Ting Wang, Kelly Carter, Andrew Kaz, Deepti Reddi, John Inadomi, Georg Luebeck, Prasad G. Iyer, Marcia Canto, Jean S. Wang, Nicholas J. Shaheen, Prashanti N. Thota, Joseph E. Willis, Thomas LaFramboise, Amitabh Chak, Sanford D. Markowitz, William M. Grady
Summary: This study identifies methylation markers that can distinguish esophageal adenocarcinoma (EAC) and high-grade dysplasia (HGD) from normal squamous epithelium (SQ) or nondysplastic Barrett's esophagus (NDBE). The results demonstrate the potential of DNA methylation-based molecular assays for the early detection of EAC using esophageal brushing samples.
CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Joan M. Griffin, Lila J. Finney Rutten, Xuan Zhu, Ziding Feng, Charles R. Rogers, Tracey L. Marsh, John M. Inadomi
Summary: This study aims to test the effectiveness of an evidence-based video intervention in improving colorectal cancer screening. The study is divided into three groups, with participants watching different types of videos, and the adherence to screening guidelines will be assessed using medical record data and surveys. This will provide evidence for integrating informational and motivational videos into clinical practice to encourage colorectal cancer screening.
CONTEMPORARY CLINICAL TRIALS
(2022)
Editorial Material
Gastroenterology & Hepatology
Beth A. Mccormick, John M. Inadomi
Article
Public, Environmental & Occupational Health
Rachel B. Issaka, Ari Bell-Brown, Jason Kao, Cyndy Snyder, Dana L. Atkins, Lisa D. Chew, Bryan J. Weiner, Lisa Strate, John M. Inadomi, Scott D. Ramsey
Summary: In safety-net healthcare systems, completion of colonoscopy within one year after an abnormal FIT result is often below 50%. This study found a discordance between documented reasons in electronic health records (EHR) and patient-reported reasons for lack of colonoscopy. Patient-related factors were the most common reasons for lack of follow-up.
PREVENTIVE MEDICINE REPORTS
(2022)
Article
Medicine, General & Internal
Aruna Kamineni, V. Paul Doria-Rose, Jessica Chubak, John M. Inadomi, Douglas A. Corley, Jennifer S. Haas, Sarah C. Kobrin, Rachel L. Winer, Jennifer Elston Lafata, Elisabeth F. Beaber, Joshua S. Yudkin, Yingye Zheng, Celette Sugg Skinner, Joanne E. Schottinger, Debra P. Ritzwoller, Jennifer M. Croswell, Andrea N. Burnett-Hartman
Summary: This review evaluates the reporting of harms in U.S. cancer screening guidelines and identifies inconsistencies and opportunities for improvement. The guidelines do not fully report harms for any specific organ type or category across organ types. Reporting of harms is most complete for prostate cancer screening and least complete for colorectal cancer screening. Future work should consider nuances of each organ-specific screening process and explore optimal ways to determine net screening benefit. Improved harms reporting can aid decision making and improve cancer screening outcomes.
ANNALS OF INTERNAL MEDICINE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Ji Yoon Yoon, Julian A. Abrams, Joel H. Rubenstein, Shailja Shah, Jake Kim, John M. Inadomi, David A. Katzka, Michelle K. Kim, Chin Hur
Meeting Abstract
Gastroenterology & Hepatology
Joel H. Rubenstein, Amir-Houshang Omidvari, Brianna Lauren, William D. Hazelton, Francesca Lim, Sarah Xinhui Tan, Chung Yin Kong, Minyi Lee, Ayman Ali, Chin Hur, John M. Inadomi, Georg Luebeck, Iris Lansdorp-Vogelaar