Journal
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
Volume 47, Issue 7, Pages 1311-1319Publisher
WILEY
DOI: 10.1111/1440-1681.13294
Keywords
Akt; c-Myc signalling; cell invasion; lung cancer stem-like cells; Puerarin 6 ''-O-xyloside; self-renewal
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Funding
- Beijing Key Laboratory of Bio-characteristic Profiling for Evaluation of Rational Drug Use [2019-KF10]
- Youth Fund of Beijing Shijitan Hospital, Capital Medical University [2016-C11]
- Educational Commission of Liaoning Province, China [LQ2017044]
- Liaoning Natural Science Foundation, China [20180550642]
- National Natural Science Foundation of China [81773891]
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Cancer stem cells have been identified as the major cause of cancer initiation and progression. To investigate the effects of puerarin 6 ''-O-xyloside (PXY), derived from Pueraria lobata (Willd.) Ohwi, on lung cancer stem cells, we enriched and identified a subpopulation of lung cancer stem-like cells (LCSLCs) derived from lung adenocarcinoma A549 cells with traits including high self-renewal and invasive capability in vitro, elevated tumourigenicity in vivo, and high expression of stem cell markers CD44, CD133 and aldehyde dehydrogenase 1 (ALDH1). We found that PXY could impair cell viability, suppress self-renewal and invasive capability, and decrease CD133, CD44 and ALDH1 mRNA expression in LCSLCs in a dose-dependent manner. Furthermore, we showed that PXY suppressed the self-renewal and invasive capability of LCSLCs at least in part through suppressing the activation of Akt/c-Myc signalling. In conclusion, PXY can block the traits of LCSLCs, indicating that PXY may be a candidate compound for lung adenocarcinoma therapy via eliminating LCSLCs.
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