Journal
CLINICA CHIMICA ACTA
Volume 499, Issue -, Pages 75-80Publisher
ELSEVIER
DOI: 10.1016/j.cca.2019.08.031
Keywords
Long noncoding RNA; OIP5-AS1; Mechanism; Cancer
Categories
Funding
- National Natural Science Foundation of China [81201865]
- Natural Science Foundation of Shandong Province [ZR2017QH004]
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Long noncoding RNAs (lncRNAs) can be over two hundred nucleotides in length and lack an obvious open reading frame (ORF). Interestingly, these RNAs form a group of nucleic acids involved in a variety of diverse cellular mechanisms involving proliferation, differentiation, apoptosis,and senescence. Given these characteristics, it is not unexpected that the aberrant expression of certain lncRNAs is strongly linked to oncogenesis and tumor advancement. OIP5-AS1, a prominent tumor-associated lncRNA, contributes to intricate cellular mechanisms during the evolution of malignant tumors. For example, it not only represses cyclin G-associated kinase (GAK) expression thus impacting mitosis, but also regulates cell proliferation and apoptosis in many cancers, including lung adenocarcinoma, breast, glioma and hepatoblastoma. In this paper, we review our current understanding of OIP5-AS1 in carcinogenesis and its potential application as a clinical biomarker or therapeutic target in malignancy.
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