Morphology and size controlled synthesis of Co-doped MIL-96 by different alkaline modulators for sensitively detecting alpha-fetoprotein

This work introduces a simple and facile approach for the morphology and size controlled synthesis of Co-doped MIL-96. By using different bases as modulators, Co-doped MIL-96 was obtained with sizes that varied from 5 mu m to 300 nm, and four different morphologies, including hexagonal prism, icosahedron, hexagonal spindle and ellipsoid. Among these, nano-sized Co-doped MIL-96 with an ellipsoid morphology exhibited the highest electroactive surface area and good conductivity as well as the best electrochemical sensing performance towards alpha-fetoprotein. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.