Article
Marine & Freshwater Biology
Feng Zhao, Mengna Zhang, Mengyu Guo, Manman Duan, Junyue Zheng, Xiangguang Chen, Yinchi Liu, Lihong Qiu
Summary: The study demonstrated that exposure to sublethal concentrations of MET induced liver injury, inflammation, and lipid metabolism disorders in adult zebrafish.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Feng Yang, Ziyu Zhao, Haiji Zhang, Liping Zhou, Liang Tao, Qin Wang
Summary: The study used zebrafish as a model to investigate the toxicity of BPS and found that excess ROS production may trigger multiple toxic effects. Pathway enrichment analysis and protein-protein network analysis identified key pathways and interaction proteins associated with BPS exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Yingyu Hou, Xinyue Zhang, Xixia Liu, Qin Wu, Jianjun Hou, Ping Su, Qian Guo
Summary: This study investigated the concentration changes of 5-HMF and FF in milk powder during cold storage and compared the toxic effects of 5-HMF on the oxidative stress system of zebrafish embryos in water and milk powder matrix. The results showed that 5-HMF concentration remained stable, while FF degraded over time. High levels of 5-HMF exposure resulted in developmental toxicity and induced oxidative stress.
Article
Biochemistry & Molecular Biology
Ajay Guru, Gokul Sudhakaran, Manikandan Velayutham, Raghul Murugan, Raman Pachaiappan, Ramzi A. Mothana, Omar M. Noman, Annie Juliet, Jesu Arockiaraj
Summary: This study investigated the therapeutic activity of daidzein against gentamicin-induced nephrotoxicity in vitro and in vivo. Daidzein was found to protect MDCK cells from inflammation and apoptosis caused by gentamicin. In the zebrafish model, daidzein treatment showed a strong anti-inflammatory effect and normalized histopathological alterations caused by gentamicin. Daidzein also downregulated the expression of pro-inflammatory cytokines in kidney inflammation. These results suggest that daidzein could potentially prevent nephrotoxic conditions through inhibiting pro-inflammatory cytokines and its antioxidant property.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wannakarn Kitipaspallop, Preecha Phuwapraisirisan, Woo-Keun Kim, Chanpen Chanchao, Wittaya Pimtong
Summary: This study evaluated the developmental toxicity of sesamin in zebrafish embryos and found that it did not cause any harm to the embryos. It also showed evidence of anti-angiogenesis, antioxidant, and anti-inflammatory activities.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Article
Fisheries
Li Ding, Kaiming Luo, Carl G. Feng, Stefan H. Oehlers
Summary: The study found that while PDT increased the recruitment of neutrophils and macrophages in the inflammatory response of zebrafish, it did not provide protection against infection in zebrafish larvae.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jae Seung Lee, Yusuke K. Kawai, Yuri Morita, Adrian Covaci, Akira Kubota
Summary: Recent evidence has shown that organophosphorus flame retardants (OPFRs) can cause various toxic effects, including endocrine disruption. This study investigated the estrogenic and growth inhibitory responses to OPFR metabolites compared to their parent compounds using zebrafish eleutheroembryos. The findings demonstrated that different metabolites had different effects on estrogenic responses and growth inhibition.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Environmental Sciences
Hongyi Xian, Zhiming Li, Rongyi Ye, Mingzhu Dai, Yu Feng, Ruobing Bai, Jie Guo, Xiliang Yan, Xingfen Yang, Da Chen, Zhenlie Huang
Summary: 4-Methylbenzylidene camphor (4-MBC), a widely-used UV filter in cosmetics, has estrogenic effects on zebrafish larvae, causing changes in fluorescence and hypoactivity. It upregulates estrogen receptor alpha (ERα) mRNA and disrupts acetylcholinesterase and acetylcholine activities, leading to behavioral phenotypes. This study provides novel insights into the brain-liver-gonad axis and how 4-MBC disturbs brain and liver development.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Yan-Kun Zhang, Huai-Yang Ke, Yong-Qiang Qin, Han-Ye Ju, Yu-Mei Chen, Fang Lin, Ji-Liang Zhang, Xiao-Ping Diao
Summary: In this study, exposure of clown anemonefish to BP-3 resulted in disrupted liver lipid metabolism, including morphological changes, lipid droplet accumulation, and abnormal lipid content and enzyme activity. Transcriptome analysis revealed that several pathways related to fat digestion, PPAR signaling, and circadian rhythm were affected. qRT-PCR validation confirmed the differential expression of key genes involved in lipid metabolism. Overall, this study provides insights into the physiological and molecular responses of clown anemonefish to BP-3 exposure.
ENVIRONMENTAL POLLUTION
(2023)
Review
Nutrition & Dietetics
Magdalena Majdan, Barbara Bobrowska-Korczak
Summary: Inflammation plays a crucial role in many diseases, and a proper diet can have a significant impact on the inflammatory process. Recent studies have found that active compounds in fruits have anti-inflammatory and antioxidant effects, which are important for maintaining health and reducing the risk of diseases.
Article
Multidisciplinary Sciences
Victor A. Adebayo, Olusola Bolaji Adewale, Scholastica Onyebuchi Anadozie, Olukemi Adetutu Osukoya, Tajudeen Olabisi Obafemi, Deborah Funmilayo Adewumi, Olajumoke Tolulope Idowu, Amos Onasanya, Abiodun Ayodele Ojo
Summary: Plants have compounds that can be used as reducing agents for the green synthesis of gold nanoparticles (AuNPs), which are being considered for biomedical applications. Exposure to cadmium (Cd) can impair the function of organs like the kidney and liver. This study investigated the bioactive compounds in Nymphaea lotus (NL) and the potential of its biosynthesized AuNPs (NL-AuNPs) to mitigate Cd-induced nephrotoxicity in rats. The bioactive compounds in NL were identified using gas chromatography-mass spectroscopy (GCMS), and AuNPs were synthesized using aqueous extract of NL. The NL-AuNPs showed ameliorative effects against Cd-induced kidney damage in rats, with a dose of 5 mg/kg being the most effective.
Article
Agronomy
Maria Irakli, Anastasia Kargiotidou, Evangelia Tigka, Dimitrios Beslemes, Maria Fournomiti, Chrysanthi Pankou, Kostoula Stavroula, Nektaria Tsivelika, Dimitrios N. Vlachostergios
Summary: The health-promoting effects of lentil seeds are due to phenolic compounds and antioxidants, making lentils a potential source of functional food or feed ingredients. This study evaluated the impact of genotype and growing environment on phytochemical contents and antioxidant activities of lentil cultivars. Results showed significant variations in bioactive components due to genetic and environmental effects, with flavanols being the main phenolic compounds in hydrophilic extracts and tocopherols being dominant in lipophilic extracts. Principal component analysis identified genotypes with high antioxidant content and stability across environments, suggesting promising genetic material for further research.
Article
Endocrinology & Metabolism
Xi Tao, Yaxin Xu, Joseph Adu-Amankwaah, Zheng Gong, Yuxuan Wang, Fei Huang, Hong Sun
Summary: Cardiac lipid accumulation and inflammation are associated with stress. Estrogen has been shown to reduce lipid deposition and have anti-inflammatory properties, but the exact mechanism is unknown. This study investigated the role of the NLRP3 inflammasome in lipid accumulation during stress and the regulatory mechanism of estrogen in this process.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Weidong Zhang, Jiachao Wang, Jianshi Song, Yanru Feng, Shujuan Zhang, Na Wang, Shufeng Liu, Zhixue Song, Kaoqi Lian, Weijun Kang
Summary: This study evaluated the effects of residual low-concentrations of Glyphosate (GLY) and its degradation product AMPA on zebrafish embryos, finding developmental toxicity including increased heart rates, arrhythmia, cardiac defects, and altered gene transcription levels. Pericardial edema and bone deformation may be caused by inhibition of specific enzymes after exposure to GLY and AMPA. The results suggest that typical environmental residual concentrations of GLY and AMPA have similar developmental toxicity in zebrafish embryos.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Engineering, Environmental
Xingli Zhang, Jing Shi, Peng Yuan, Tengfei Li, Zhiguo Cao, Wei Zou
Summary: The degradation of microplastics in the gastrointestinal environment and the associated risks of egested microplastics to organisms were studied. Polyamide and polystyrene microplastics exhibited differential degradation, with polystyrene having a more negative impact on the development of juvenile zebrafish.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Neuroimaging
Dapeng Sun, Baixue Jia, Xu Tong, Peter Kan, Xiaochuan Huo, Anxin Wang, Raynald, Gaoting Ma, Ning Ma, Feng Gao, Dapeng Mo, Ligang Song, Xuan Sun, Lian Liu, Yiming Deng, Xiaoqing Li, Bo Wang, Gang Luo, Yongjun Wang, Zeguang Ren, Zhongrong Miao
Summary: This study investigated the incidence, predictors, and clinical impact of parenchymal hemorrhage (PH) after endovascular treatment (EVT) in Chinese patients with acute ischemic stroke (AIS) caused by anterior circulation large vessel occlusion (LVO). The findings showed that low admission ASPECTS, high serum glucose, and elevated neutrophil-to-lymphocyte ratio (NLR) were independent predictors of PH, while underlying intracranial atherosclerotic stenosis (ICAS) and intracranial angioplasty/stenting were associated with a lower risk of PH. Additionally, patients with PH had worse functional outcomes.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Obstetrics & Gynecology
Xiang-Lan Liu, Li Ding, Xiao Lu, Yan-Jiao Hu, Xiao-Li Zhou, Dong-Liang Lin
Summary: A cervical yolk sac tumor in a 44-yr-old woman shares similarities with adenocarcinomas with enteroblastic differentiation (AEBDs) in the digestive system. The tumor exhibits a glandular-predominant growth pattern and is positive for p16, glypican-3 (GPC3), spalt-like transcription factor 4 (SALL4), CDX-2, and p53. TP53 mutation and HPV 35 infection were detected. This aggressive tumor should be recognized for its enteroblastic component in pathology reports.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2023)
Article
Nutrition & Dietetics
Qi Cui, Yang Xia, Yashu Liu, Yifei Sun, Kang Ye, Wenjie Li, Qijun Wu, Qing Chang, Yuhong Zhao
Summary: This study evaluated the reproducibility and validity of the Food Frequency Questionnaire (FFQ) for residents in northeast China. The findings demonstrated that the FFQ is reliable and valid for assessing the intake of most foods and nutrients.
BRITISH JOURNAL OF NUTRITION
(2023)
Correction
Obstetrics & Gynecology
Sadaf Pervaz, Amin Ullah, Enoch Appiah Adu-Gyamfi, Jones Lamptey, Sanjay Kumar Sah, Mei-Jiao Wang, Ying-Xiong Wang
REPRODUCTIVE SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Qing Chang, Qijun Wu, Yang Xia, Hehua Zhang, Shanyan Gao, Yixiao Zhang, Yuan Yuan, Jing Jiang, Hongbin Qiu, Jing Li, Chunming Lu, Chao Ji, Xin Xu, Donghui Huang, Huixu Dai, Zhiying Zhao, Hang Li, Xiaoying Li, Xiaosong Qin, Caigang Liu, Xiaoyu Ma, Xinrui Xu, Da Yao, Yuhong Zhao
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Engineering, Ocean
Zhuangcai Tian, Hanlu Liu, Shaotong Zhang, Jinran Wu, Jiahao Tian
Summary: This paper proposes a method for predicting the shear stress induced by shoaling internal solitary waves (ISWs) based on machine learning. The developed approach has been proven to be effective and accurate in predicting the shear stress and can be used to evaluate the safety and stability of ocean engineering. This method is of great significance in promoting the development of deep-water ocean engineering.
MARINE GEORESOURCES & GEOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jing Liu, Ji Lv, Zheyi Liu, Zheng Fang, Can Lai, Shan Zhao, Mingliang Ye, Fangjun Wang
Summary: In this study, it was discovered that interfacial hydrophobic hydration significantly enhances H-bond networks at the interface between a glycan-modified adsorbent and a methanol-water-acetonitrile ternary solution. This enhancement promotes the adsorbent-solution heterogeneous glycan-glycan recognition and interaction, leading to improved glycopeptide enrichment. Compared with the commonly used hydrophilic-interaction enrichment strategy, more intact N- and O-glycopeptides are identified and the enrichment recoveries are significantly increased. This study also provides in-depth profiling of N- and O-glycosylation on SARS-CoV-2 S1 and hACE2 proteins.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Psychology, Multidisciplinary
Yefeng Chen, Yiwen Pan, Haohan Cui, Xiaolan Yang
Summary: This article proposes a possible mechanism that people may have underconfidence bias in information updating due to motivated reasoning, which generates the asymmetric pattern in contagion, different from the overconfident bias observed in the literature. The study designs an experiment to relate unethical behavior to social learning, where subjects decide whether to conduct unethical behavior publicly based on private information about penalty. The results confirm that people rely more on others' decisions than their own signal, suggesting the bias facilitates the contagion.
BEHAVIORAL SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Mengfei Li, QianQian Yang, Lili Fan, Xiaojie Dai, Zixi Kang, Rongming Wang, Daofeng Sun
Summary: Researchers have developed alternative electrocatalysts with high stability for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). The electrocatalyst, composed of hollow CoOx nanoparticles embedded in carbon nanofibers, showed excellent long-term stability and promising performance in reversible Zn-air batteries. The remarkable electrocatalytic performance is attributed to the optimized adsorption of *OOH intermediate and reduced free energy of the potential-limiting step.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Letter
Biochemistry & Molecular Biology
Qiao-ling Ruan, Zhi-chao Wang, Cheng-jiang Wei, Wei Wang, Qing-luan Yang, Jing Wu, Yan-min Wan, Ling-ling Ge, Wen-hong Zhang, Qing-feng Li
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Physiology
Xinwei Wang, Jiulong Song, Peng Xia, Qiang Lin, Anliang Chen, Kai Cheng, Fane Kong, Yi Shi, Xueping Li
Summary: High-intensity interval training (HIIT) is a physical therapy that can alleviate osteoarthritis (OA)-associated hyperalgesia. Cacna2d1, a subunit protein of calcium channel, plays a crucial role in nerve cell activity. However, the effect of HIIT on OA hyperalgesia and the involvement of Cacna2d1 remains unclear. In this study, OA rat models were established using monosodium iodoacetate (MIA) injection, and different groups were compared. Pain threshold, cartilage analysis, Cacna2d1 expression, and pain neurotransmitters were measured. The results demonstrated that HIIT could attenuate OA-associated hyperalgesia, possibly through the down-regulation of Cacna2d1 expression.
JOURNAL OF PHYSIOLOGICAL SCIENCES
(2023)
Article
Engineering, Biomedical
Ying Hu, Yan Liu, Siqi Zhang, Ting Zhang, Bin Dai, Bo Peng, Hongbo Yang, Yakang Dai
Summary: This study proposes a cross-space convolutional neural network (CS-CNN) for the classification of four-class motor imagery-electroencephalogram (MI-EEG), aiming to improve classification accuracy and robustness. The algorithm utilizes modified customized band common spatial patterns (CBCSP) and duplex mean-shift clustering (DMSClustering) to express specific rhythms and source distribution information in cross-space, and extracts multi-view features from time, frequency, and space domains to fuse the characteristics from two spaces and classify them using CNN. Experimental results show that the proposed algorithm achieves a classification accuracy of 96.05% (with real MRI information) and 94.79% (without MRI) in the private dataset. Moreover, in the BCI competition IV-2a, CS-CNN outperforms state-of-the-art algorithms with an accuracy improvement of 1.98% and a standard deviation reduction of 5.15%.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Immunology
Zhishuo Wang, Chenghua Yan, Qizhen Du, Yuying Huang, Xuezhen Li, Dan Zeng, Ruizhi Mao, Rama Krishna Gurram, Shipeng Cheng, Wangpeng Gu, Lin Zhu, Weiguo Fan, Liyan Ma, Zhiyang Ling, Ju Qiu, Dangsheng Li, Enmei Liu, Yaguang Zhang, Yiru Fang, Jinfang Zhu, Bing Sun
Summary: This study found a negative correlation between the neurotransmitter serotonin and the cytokines IL-5 and IL-13 produced by ILC2s, which are related to depression. Serotonin can alleviate lung inflammation by suppressing ILC2 activation. The serotonin receptor HTR2A is highly expressed on ILC2s and can be targeted with an agonist called DOI to inhibit ILC2 activation and reduce type 2 immune response. Targeting HTR2A on ST2(+) ILC2s could be a potential treatment strategy for type 2 lung inflammation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xi Lin, Lixing Dai, Qinqin Yang, Qizhi Yang, Hongjian He, Lingceng Ma, Jingjing Liu, Jingliang Cheng, Congbo Cai, Jianfeng Bao, Zhong Chen, Shuhui Cai, Jianhui Zhong
Summary: This study developed a real-time abdominal T-2 mapping method that does not require breath-holding or respiratory-gating. The single-shot multiple overlapping-echo detachment (MOLED) pulse sequence was used for free-breathing T-2 mapping of the abdomen. Deep learning was utilized to untangle the non-linear relationship between the MOLED signal and T-2 mapping. A synthetic data generation flow based on Bloch simulation, modality synthesis, and randomization was proposed to overcome the inadequacy of real-world training set.
EUROPEAN RADIOLOGY
(2023)
Article
Chemistry, Physical
Tengda Wang, Shaoying Dai, Jie Wang, Bin Liu, Meiwen Cao, Bo Guan, Yuchun Han, Yilin Wang
Summary: The large-scale use of detergents for oil-fouling removal in industry generates a significant amount of wastewater, leading to economic and environmental problems. This study presents a recyclable, efficient, and eco-friendly approach to remove oil-fouling by constructing a dynamic imine-based surfactant.