Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 15, Issue 3, Pages 352-355Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201901517
Keywords
[4+2] annulation; dihydroindolizine; indolizines; pyridine-ring construction; transition metal-free
Categories
Funding
- National Key R&D Program of China [2017YFA0204704]
- National Natural Science Foundation of China [21602105]
- Natural Science Foundation of Jiangsu Province [BK20171460]
- National Key Basic Research Program of China (973) [2015CB932200]
Ask authors/readers for more resources
An efficient method for the synthesis of polysubstituted indolizines has been developed based on formal [4+2] annulation of 1-acetylaryl 2-formylpyrroles with enals, followed by oxidative aromatization. Pyridine-type six-membered rings were constructed in this transformation. This transition metal-free reaction features mild reaction conditions, a broad substrate scope, and excellent functional group tolerance. Notably, the formyl group is well tolerated under reaction conditions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available