Article
Hematology
Roswitha Luftinger, Natalia Zubarovskaya, Jacques-Emmanuel Galimard, Annamaria Cseh, Elisabeth Salzer, Franco Locatelli, Mattia Algeri, Akif Yesilipek, Josu de la Fuente, Antonella Isgro, Amal Alseraihy, Emanuele Angelucci, Frans J. Smiers, Giorgia La La Nasa, Marco Zecca, Tunc Fisgin, Emel Unal, Katharina Kleinschmidt, Christina Peters, Arjan Lankester, Selim Corbacioglu
Summary: Significant advances in supportive care have improved the life expectancy of patients with transfusion-dependent thalassemia major (TDT), but iron overload remains a barrier to long-term survival. This retrospective analysis compared the outcomes of TDT patients undergoing hematopoietic stem cell transplantation (HSCT) with different conditioning regimens, and found that both busulfan-fludarabine-based and treosulfan-fludarabine-based conditioning resulted in high cure rates. The main causes of death were infections, graft-versus-host disease, and rejection.
ANNALS OF HEMATOLOGY
(2022)
Article
Biophysics
Borje S. Andersson, Peter F. Thall, Junsheng Ma, Benigno C. Valdez, Roland Bassett, Julianne Chen, Sairah Ahmed, Amin Alousi, Qaiser Bashir, Stefan Ciurea, Alison Gulbis, Rita Cool, Jitesh Kawedia, Chitra Hosing, Partow Kebriaei, Steve Kornblau, Alan Myers, Betul Oran, Katayoun Rezvani, Nina Shah, Elizabeth Shpall, Simrit Parmar, Uday R. Popat, Yago Nieto, Richard E. Champlin
Summary: Pretransplant conditioning with Fludarabine-Busulfan is safe, but clofarabine has improved antileukemic activity. This study aimed to evaluate the efficacy of Flu+Clo-Bu (FCB) compared to Flu-Bu in AML/MDS patients undergoing allogeneic transplantation. The results showed that FCB had a lower relapse incidence but higher non-relapse mortality compared to Flu-Bu. FCB showed improved disease control in NCR patients with low HCT-CI scores. Confirmatory trials are needed to further assess the effectiveness of FCB.
BONE MARROW TRANSPLANTATION
(2022)
Article
Biophysics
Shuhei Kurosawa, Yoshimitsu Shimomura, Hidehiro Itonaga, Yuho Najima, Takeshi Kobayashi, Yukiyasu Ozawa, Yoshinobu Kanda, Shinichi Kako, Toshiro Kawakita, Ken-ichi Matsuoka, Yumiko Maruyama, Shuichi Ota, Hideyuki Nakazawa, Kazunori Imada, Junya Kanda, Takahiro Fukuda, Yoshiko Atsuta, Jun Aoki
Summary: Myeloablative conditioning with Fludarabine/Busulfan (Flu/Bu4) and busulfan/cyclophosphamide (Bu4/Cy) prior to allogeneic hematopoietic stem cell transplantation (allo-HSCT) showed similar outcomes in MDS patients, with no patients having a favorable overall survival rate in either group.
BONE MARROW TRANSPLANTATION
(2021)
Article
Hematology
Kimimori Kamijo, Yoshimitsu Shimomura, Akihito Shinohara, Shohei Mizuno, Minoru Kanaya, Yoshiaki Usui, Sung-Won Kim, Takahide Ara, Ishikazu Mizuno, Takuro Kuriyama, Hideyuki Nakazawa, Ken-ichi Matsuoka, Shigeru Kusumoto, Nobuo Maseki, Masaki Yamaguchi, Takashi Ashida, Makoto Onizuka, Takahiro Fukuda, Yoshiko Atsuta, Eisei Kondo
Summary: By comparing the effects of Flu/Bu2 and Flu/Bu4 on patients with non-Hodgkin lymphoma undergoing allogeneic hematopoietic cell transplantation, the study found that Flu/Bu4 was associated with higher nonrelapse mortality and lower 5-year overall survival compared to Flu/Bu2.
ANNALS OF HEMATOLOGY
(2023)
Article
Oncology
Yiwen Ling, Li Xuan, Na Xu, Fen Huang, Zhiping Fan, Ziwen Guo, Xiaojun Xu, Hui Liu, Ren Lin, Sijian Yu, Haiyan Zhang, Hua Jin, Meiqing Wu, Can Liu, Xinquan Liang, Ruiming Ou, Yuping Zhang, Xiaodan Liu, Hong Qu, Xiao Zhai, Jing Sun, Ying Zhao, Qifa Liu
Summary: The BuFlu regimen has lower TRM and RRT and similar relapse compared to the BuCy regimen in haplo-HCT for patients with AML.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Biophysics
Albert C. Yeh, Paul O'Donnell, Gary Schoch, Paul J. Martin, Chris McFarland, Jeannine S. McCune, Jason P. Cooper, Kris Doney, Mary E. D. Flowers, Mohamed L. Sorror, Frederick R. Appelbaum, Barry E. Storer, Ted Gooley, H. Joachim Deeg
Summary: In this study, long-term outcomes in MDS and AML patients receiving different conditioning regimens were evaluated, with BuFluTHY conditioning associated with lower rates of chronic GVHD and long-term mixed T-cell chimerism, but potentially higher risks of relapse and non-relapse mortality.
BONE MARROW TRANSPLANTATION
(2022)
Article
Hematology
Jacinth Joseph, Samer A. Srour, Denai R. Milton, Jeremy L. Ramdial, Neeraj Y. Saini, Amanda L. Olson, Qaiser Bashir, Betul Oran, Amin M. Alousi, Chitra Hosing, Muzaffar H. Qazilbash, Partow Kebriaei, Elizabeth J. Shpall, Richard E. Champlin, Uday R. Popat
Summary: In patients with myelofibrosis (MF) who underwent allogeneic stem cell transplantation (allo-SCT), using a uniform myeloablative conditioning regimen and methotrexate-based graft-versus-host disease prophylaxis, donor choice and Hematopoietic Cell Transplantation Comorbidity Index (HCT-CI) were found to be the two strongest predictors for improved survival.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Immunology
David Cruz, Rocio Rodriguez-Romanos, Marta Gonzalez-Bartulos, Irene Garcia-Cadenas, Rafael de la Camara, Inmaculada Heras, Ismael Buno, Nazly Santos, Natalia Lloveras, Pilar Velarde, Esperanza Tuset, Carmen Martinez, Marcos Gonzalez, Guillermo F. F. Sanz, Christelle Ferra, Antonia Sampol, Rosa Coll, Jose A. A. Perez-Simon, Javier Lopez-Jimenez, Manuel Jurado, David Gallardo
Summary: In this study, the association between LAG3 gene polymorphism and the clinical outcomes of alloHSCT was investigated. The results showed that patients transplanted from donors with the TT genotype had a higher incidence of severe acute GVHD and worse overall survival, disease-free survival, and transplant-related mortality. The combination of LAG3 and PDCD1 genotypes allowed for a good stratification of the risk of acute GVHD, TRM, OS, and DFS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Jacqueline S. Garcia, Haesook T. Kim, H. Moses Murdock, Corey S. Cutler, Jennifer Brock, Mahasweta Gooptu, Vincent T. Ho, John Koreth, Sarah Nikiforow, Rizwan Romee, Roman Shapiro, Fiona Loschi, Jeremy Ryan, Geoffrey Fell, Hannah Q. Karp, Fabienne Lucas, Annette S. Kim, Danielle Potter, Thelma Mashaka, Richard M. Stone, Daniel J. DeAngelo, Anthony Letai, R. Coleman Lindsley, Robert J. Soiffer, Joseph H. Antin
Summary: This study investigated the addition of the selective BCL-2 inhibitor venetoclax to reduced-intensity conditioning chemotherapy in adult patients with high-risk AML, MDS, and MDS/MPN undergoing transplant. The results showed that this combination therapy was feasible, safe, and could potentially reduce the risk of posttransplant relapse in these patients. Further assessment of maintenance therapy after venetoclax plus FluBu2 transplant is ongoing to address relapse risk.
Article
Oncology
Brendan Rasor, Tyler Dickerson, Qiuhong Zhao, Patrick Elder, Jonathan E. Brammer, Karilyn Larkin, Samantha Jaglowski, Alice Mims, Sam Penza, Sumithira Vasu, Sarah A. Wall, Basem William, Ayman Saad, Julianna V. F. Roddy, Hannah Choe, Marcin Puto
Summary: The retrospective cohort study compared the efficacy and tolerability of busulfan AUC target of 16.4 mg x Hr/L per day (FluBu4K) and a conventional RIC regimen (FluBu2) in patients with AML or MDS. The results suggest that for select patients, there may be benefit in choosing FluBu4K over FluBu2, as it showed a lower cumulative incidence of relapse at 18 months.
LEUKEMIA & LYMPHOMA
(2021)
Article
Oncology
Benigno C. Valdez, Bin Yuan, David Murray, Jeremy Leon Ramdial, Yago Nieto, Uday Popat, Xiaowen Tang, Borje S. Andersson
Summary: Combinations of nucleoside analog(s) and DNA alkylating agent(s) are used for cancer treatment. This study found that adding the HDAC inhibitor SAHA and the PARP inhibitor olaparib to the established drug combination can enhance the cytotoxicity of AML cells.
FRONTIERS IN ONCOLOGY
(2023)
Article
Hematology
Chikako Ohwada, Shingo Yamazaki, Katsuhiro Shono, Kensuke Kayamori, Yutaro Hino, Nagisa Oshima-Hasegawa, Tomoya Muto, Shokichi Tsukamoto, Shio Mitsukawa, Yusuke Takeda, Naoya Mimura, Masahiro Takeuchi, Tohru Iseki, Masahiro Onoda, Akira Yokota, Takaaki Suzuki, Itsuko Ishii, Chiaki Nakaseko, Emiko Sakaida
Summary: Pharmacokinetically (PK) guided, once-daily administration of busulfan (BU) is effective in reducing relapse in elderly patients with acute myeloid leukemia/myelodysplastic syndrome (AML/MDS), although high AUC1 values may lead to non-relapse mortality (NRM) and high AUC4 values may lower relapse rates.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2021)
Article
Medicine, General & Internal
Xing-yu Cao, Jia-qi Chen, Hui Wang, Wei Ma, Wei-wei Liu, Fang-fang Zhang, Song Xue, Lei Dong, Ting Liu, Xiao-zhen Zhao, Chan-chan Liu, Xin Xu, Yang He, Lei Wang, Jian-ling Wang
Summary: The safety and efficacy of a myeloablative conditioning (MAC) allo-HSCT regimen containing venetoclax for high-risk AML patients were evaluated, and it was concluded that venetoclax is a feasible, safe, and effective treatment option in this patient population.
ANNALS OF MEDICINE
(2023)
Article
Biophysics
Satoko Morishima, Takahiro Fukuda, Noriko Doki, Takehiko Mori, Makoto Onizuka, Toshihiro Kawakita, Chiaki Kato, Yukiyasu Ozawa, Masatsugu Tanaka, Mineo Kurokawa, Tomohiko Kamimura, Masami Inoue, Junji Tanaka, Tatsuo Ichinohe, Yoshiko Atsuta, Yasuo Morishima
Summary: This study found that specific HLAs, such as HLA-B60 and HLA-B62, are significantly associated with the risk of acute GVHD in patients undergoing allo-HSCT. HLA-B62-positive patients have a higher risk of leukemia relapse, while overall survival is not affected by these specific HLAs. The findings suggest that consideration of specific HLAs may help predict transplant outcomes.
BONE MARROW TRANSPLANTATION
(2021)
Article
Immunology
Jinye Zhu, Qingya Wang, Hanyun Ren, Yujun Dong, Yue Yin, Qian Wang, Zeyin Liang, Wei Liu, Qingyun Wang, Bingjie Wang, Yuan Li
Summary: This study retrospectively analyzed the effect of low-dose DAC treatment in AML/MDS patients undergoing allogeneic hematopoietic stem cell transplantation. The results showed that patients receiving DAC treatment had a significantly lower incidence of grade II-IV acute GVHD. This study provides a new treatment strategy for improving the prognosis of AML/MDS patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Hematology
Mi Kwon, Gloria Iacoboni, Juan Luis Reguera, Lucia Lopez Corral, Rafael Hernani Morales, Valentin Ortiz-Maldonado, Manuel Guerreiro, Ana Carolina Caballero, Maria Luisa Guerra Dominguez, Jose Maria Sanchez Pina, Alberto Mussetti, Juan Manuel Sancho, Mariana Bastos-Oreiro, Eva Catala, Javier Delgado, Hugo Luzardo Henriquez, Jaime Sanz, Maria Calbacho, Rebeca Bailen, Cecilia Carpio, Jose Maria Ribera, Anna Sureda, Javier Briones, Juan Carlos Hernandez-Boluda, Nuria Martinez Cebrian, Jose Luis Diez Martin, Alejandro Martin, Pere Barba
Summary: This retrospective study evaluated the safety and efficacy of Axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) in relapsed/refractory large B-cell lymphoma (LBCL) outside of clinical trials. The results showed that the real-world experience with these CAR-T cell therapies was comparable to the pivotal trial results.
Letter
Hematology
Maximilian Stahl, Omar Abdel-Wahab, Andrew H. Wei, Michael R. Savona, Mina L. Xu, Zhuoer Xie, Justin Taylor, Daniel Starczynowski, Guillermo F. Sanz, David A. Sallman, Valeria Santini, Gail J. Roboz, Mrinal M. Patnaik, Eric Padron, Olatoyosi Odenike, Aziz Nazha, Stephen D. Nimer, Ravindra Majeti, Richard F. Little, Steven Gore, Alan F. List, Vijay Kutchroo, Rami S. Komrokji, Tae Kon Kim, Nina Kim, Christopher S. Hourigan, Robert P. Hasserjian, Stephanie Halene, Elizabeth A. Griffiths, Peter L. Greenberg, Maria Figueroa, Pierre Fenaux, Fabio Efficace, Amy E. DeZern, Matteo G. Della Porta, Naval G. Daver, Jane E. Churpek, Hetty E. Carraway, Andrew M. Brunner, Uma Borate, John M. Bennett, Rafael Bejar, Jacqueline Boultwood, Sanam Loghavi, Jan Philipp Bewersdorf, Uwe Platzbecker, David P. Steensma, Mikkael A. Sekeres, Rena J. Buckstein, Amer M. Zeidan
Letter
Hematology
Michele Wieczorek, Myriam Labopin, Luca Castagna, Eolia Brissot, Gerard Socie, Anna Maria Raiola, Emanuele Angelucci, Arancha Bermudez Rodriguez, Ibrahim Yakoub-Agha, Mahmoud Aljurf, Charles Crawley, Jean Baptiste Mear, Maurizio Musso, Renato Fanin, Daniele Avenoso, Pascal Turlure, Cristina Tecchio, Jaime Sanz, Fabio Ciceri, Arnon Nagler, Mohamad Mohty
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Biophysics
Ryszard Swoboda, Myriam Labopin, Sebastian Giebel, Thomas Schroeder, Nicolaus Kroeger, Mutlu Arat, Bipin Savani, Alexandros Spyridonidis, Rose-Marie Hamladji, Victoria Potter, Ana Berceanu, Ibrahim Yakoub-Agha, Alessandro Rambaldi, Hakan Ozdogu, Jaime Sanz, Arnon Nagler, Mohamad Mohty
Summary: This study compared two different myeloablative conditioning regimens, FluTBI12 and FB4, before allo-HCT in AML patients. The results showed no significant differences in leukemia-free survival, overall survival, relapse incidence, and non-relapse mortality between the two groups. The incidence of acute and chronic GVHD also showed no statistical differences. In conclusion, FluTBI12 and FB4 are comparable myeloablative regimens for AML patients transplanted in CR1 and CR2.
BONE MARROW TRANSPLANTATION
(2023)
Letter
Hematology
Dai Chihara, Luuk Gras, Nienke Zinger, Nicolaus Kroeger, Jiri Mayer, Jakob Passweg, Regis Peffault de Latour, Jenny Byrne, William Krueger, Jan-Paul Bohn, Uwe Platzbecker, Igor Wolfgang Blau, Francesca Bonifazi, Grzegorz Helbig, Andrew McDonald, Martin Mistrik, Mohamad Mohty, Ron Ram, Jaime Sanz, Carlos Vallejo Llamas, Robert J. Kreitman, Patrick J. Hayden, Donal McLornan, Olivier Tournilhac, Michel van Gelder, Ibrahim Yakoub-Agha
Article
Oncology
Philipp Berning, Norbert Schmitz, Maud Ngoya, Herve Finel, Ariane Boumendil, Fengrong Wang, Xiao-Jun Huang, Olivier Hermine, Laure Philippe, Lucile Couronne, Arnaud Jaccard, Daihong Liu, Depei Wu, Hans Christian Reinhardt, Yves Chalandon, Eva Wagner-Drouet, Mi Kwon, Xi Zhang, Ben Carpenter, Ibrahim Yakoub-Agha, Gerald Wulf, Javier Lopez-Jimenez, Jaime Sanz, Helene Labussiere-Wallet, Avichai Shimoni, Peter Dreger, Anna Sureda, Won Seog Kim, Bertram Glass
Summary: In this study, researchers conducted a retrospective analysis of data from 135 patients with natural killer/T-cell lymphomas (NKTCL) who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). The results showed that allo-HSCT can achieve long-term survival in NKTCL patients.
Editorial Material
Immunology
Pedro Asensi Canto, Empar Mayordomo, Andrea Dorado, Marta Villalba, Rosana Blanco Manez, Eva Gonzalez, Miguel Salavert, Ana Facal, Pedro Chorao, Aitana Balaguer, Rafael Sivera, Juan Montoro, Juan J. Vilchez, Jose Luis Pinana, Miguel Sanz, Jaime Sanz, Nuria Muelas, Manuel Guerreiro
TRANSPLANT INFECTIOUS DISEASE
(2023)
Article
Medicine, General & Internal
Pilar Solves, Javier Marco-Ayala, Miguel Angel Sanz, Ines Gomez-Segui, Aitana Balaguer-Rosello, Ana Facal, Marta Villalba, Juan Montoro, Guillermo Sanz, Javier de la Rubia, Jaime Sanz
Summary: This study compares the transfusion requirements of patients undergoing different modalities of hematopoietic stem cell transplantation (HSCT) over a twelve-year period. The results show that transfusion requirements have significantly increased for matched related donor HSCT, while there were no significant changes for matched unrelated donor and haploidentical transplant HSCT.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Igor Stojkov, Annette Conrads-Frank, Ursula Rochau, Marjan Arvandi, Karin A. Koinig, Michael Schomaker, Moshe Mittelman, Pierre Fenaux, David Bowen, Guillermo F. Sanz, Luca Malcovati, Saskia Langemeijer, Ulrich Germing, Krzysztof Madry, Agnes Guerci-Bresler, Dominic J. Culligan, Ioannis Kotsianidis, Laurence Sanhes, Juliet Mills, Sibylle Puntscher, Daniela Schmid, Corine van Marrewijk, Alexandra Smith, Fabio Efficace, Theo de Witte, Reinhard Stauder, Uwe Siebert
Summary: This study aimed to identify determinants of low health-related quality of life (HRQoL) in patients recently diagnosed with myelodysplastic syndromes (MDS) for guiding early intervention strategies. Multiple factors, including age, sex, serum ferritin level, comorbidity burden, and Karnofsky performance status, influenced the HRQoL of MDS patients.
Article
Biophysics
Gerard Socie, Pere Barba, Arie Barlev, Jaime Sanz, Irene Garcia-Cadenas, Patrice Chevallier, Franca Fagioli, Norma Guzman-Becerra, Deepali Kumar, Per Ljungman, Arnaud Pigneux, Natalia Sadetsky, Lucrecia Yanez San Segundo, Mazyar Shadman, Jan Storek, Dhanalakshmi Thirumalai, Baodong Xing, Mohamad Mohty
Summary: EBV+ PTLD is a rare and aggressive condition that may occur following HCT. Treatment options are limited and prognosis is poor for patients with R/R EBV+ PTLD.
BONE MARROW TRANSPLANTATION
(2023)
Review
Hematology
Pedro Asensi Canto, Jaime Sanz Caballer, Pilar Solves Alcaina, Javier de la Rubia Comos, Ines Gomez Segui
Summary: The development and practical application of extracorporeal photopheresis (ECP) as a treatment for graft-versus-host disease (GVHD) is reviewed in this article, along with the underlying biological mechanisms. ECP reverses GVHD through lymphocyte apoptosis, modification of cytokine profiles, and changes in T cell subpopulations. However, logistical constraints may hinder the widespread use of this treatment.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Hematology
Chenyu Lin, Aurelie Schwarzbach, Jaime Sanz, Pau Montesinos, Patrick Stiff, Suhag Parikha, Claudio Brunstein, Corey Cutler, Caroline A. Lindemans, Rabi Hanna, Liang Piu Koh, Madan H. Jagasia, David Valcarcel, Richard T. Maziarz, Amy K. Keating, William Y. K. Hwang, Andrew R. Rezvani, Nicole A. Karras, Juliana F. Fernandes, Vanderson Rocha, Isabel Badell, Ron Ram, Gary J. Schiller, Leonid Volodin, Mark C. Walters, Nelson Hamerschlak, Daniela Cilloni, Olga Frankfurt, Joseph P. McGuirk, Joanne Kurtzberg, Guillermo Sanz, Ronit Simantov, Mitchell E. Horwitz
Summary: This article reports on the long-term effects of ex vivo-expanded cellular therapy using umbilical cord blood in 105 patients with hematologic malignancies or sickle cell hemoglobinopathy. The results show that 5% of the patients experienced secondary graft failure within 12 months, but no late cases occurred, and stable trilineage hematopoiesis and immune function were observed during long-term follow-up.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Hematology
Mohamed A. Kharfan-Dabaja, Myriam Labopin, Ernesto Ayala, Ali Bazarbachi, Didier Blaise, Jan Vydra, Stefania Bramanti, Maija Itala-Remes, Christoph Schmid, Alessandro Busca, Edouard Forcade, Werner Rabitsch, Marco Zecca, Nicolaus Kroeger, Claude-Eric Bulabois, Giovanni Grillo, Alessandro Rambaldi, Renato Fanin, Francesco Zallio, Nicola Di Renzo, Yener Koc, Yana Novis, Andrew McDonald, Concepcion Herrera Arroyo, Jaime Sanz, Arnon Nagler, Fabio Ciceri, Mohamad Mohty
Summary: The study evaluated the impact of HLA mismatches on post-allograft outcomes in haploidentical allo-HCT for acute myeloid leukemia. The results showed that the extent of HLA disparity did not affect the incidence of acute and chronic graft-versus-host disease. Overall survival, leukemia-free survival, and relapse incidence were similar between the groups.
Meeting Abstract
Oncology
Javier de la Rubia, Juan Montoro, Jaime Sanz, Aitana Balaguer, Manuel Guerreiro, Ana Facal, Marta Villalba, Pedro Chorao, Mario Arnao, Alberto Louro, Miguel Sanz
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2023)