Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 26, Issue 37, Pages 8175-8189Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201905276
Keywords
alkynes; cyclization; nitrogen compounds; pyrazoles; transition metals
Categories
Funding
- CNPq
- CAPES
- FAPERGS
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The easy preparation and functionalization of pyrazoles associated with their innumerable biological properties have made this class of N-heterocycles very attractive for the development of new synthetic routes and applications. The cyclization reactions of alkynes and nitrogen compounds represent a powerful tool for the preparation of pyrazoles. This Review covers the recent advances in the preparation of pyrazoles by reacting alkynes and nitrogen compounds under transition-metal-catalyzed or metal-free conditions.
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