Journal
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
Volume 36, Issue 2, Pages 194-202Publisher
HIGHER EDUCATION PRESS
DOI: 10.1007/s40242-019-0031-4
Keywords
Signal amplification; DNA nanotechnology; Fluorescence; miRNA detection; Biosensing and bioimaging
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Funding
- National Key R&D Program of China [2017YFA0208000]
- National Natural Science Foundation of China [21974127, 21525523, 21722507, 21874121, 21974128]
- Natural Science Foundation of Zhejiang Province, China
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In this review, the most recent progresses in the field of fluorescence signal amplification strategies based on DNA nanotechnology for miRNA are summarized. The types of signal amplification are given and the principles of amplification strategies are explained, including rolling circle amplification(RCA), catalytic hairpin assembly (CHA), hybridization chain reaction(HCR) and DNA walker. Subsequently, the application of these signal amplification methods in biosensing and bioimaging are covered and described. Finally, the challenges and the outlook of fluorescence signal amplification methods for miRNA detection are briefly commented.
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