Journal
CHEMICAL ENGINEERING JOURNAL
Volume 378, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2019.122171
Keywords
Biodegradable mesoporous silica nanoparticles; Nanocarriers; High-efficiency targeting; Redox-responsive; Chemotherapy
Categories
Funding
- National Natural Science Foundation of China [31570984, 31771048, 21574019, 31571735, 81522049]
- Fundamental Research Funds for the Central Universities [2232018A3-07]
- Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents
- Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Traditional Chinese Pharmacology), Zhejiang Chinese Medical University [ZYAOX2018008]
- Zhejiang Provincial Ten Thousands Program for Leading Talents of Science and Technology Innovation
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Mesoporous silica nanoparticles (MSN) attract extensive attention in area of cancer diagnosis and therapy because of their controllable nanostructures, easy surface modification and stable synthesis methods. However, their biodegradability was still controversial. This work explored the degradation effect of a type of biodegradable MSN (bMSN) in different environments and simultaneously endowed it with imaging functions and high-efficiency targeting effect on cancer cell, thus forming a multifunctional biodegradable drug carrier (bMSNss- GABA) for cancer theranostics. The bovine serum albumin-based Gd/Au complex (BSA-Gd/Au) was wrapped on the surface of bMSN through disulfide linkage, acting as contrast agent for magnetic resonance (MR) and fluorescence imaging, and then folate (FA), whose receptor (FR) is overexpressed in KB human oral epidermoid carcinoma cells, was modified on the nanocarriers as a targeting ligand. TEM revealed the degradation process of bMSN and a series of characterization methods verified the successful construction of bMSN-ss-GABA. Doxorubicin hydrochloride (DOX) loaded bMSN-ss-GABA (DOX@ bMSN-ss-GABA) was proved with redox-responsiveness, thereby triggering rapid drug release under specific tumor microenvironment of high glutathione concentration. Further, the excellent imaging capability was also fully inspected. What's more, the results of endocytosis and tumor growth inhibition of DOX@bMSN-ss-GABA demonstrated the highly effective targeting effect of hybird nanocarriers. Therefore, the prepared DOX@bMSN-ss-GABA might be used as a promising nanotheranostic agent for KB human oral epidermoid carcinoma.
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