Journal
CELL PROLIFERATION
Volume 53, Issue 2, Pages -Publisher
WILEY
DOI: 10.1111/cpr.12747
Keywords
cancer; epigenetics; JMJD6 protein; jumonji domain-containing histone demethylases
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Funding
- National Natural Science Foundation of China [81602492]
- National Key Research and Development Program of China [2016YFA0201402]
- National Major Scientific, Technological Special Project for Significant New Drugs Development [2018ZX09733001]
- Excellent Youth Foundation of Sichuan Scientific Committee Grant in China [2019JDJQ0008]
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The jumonji domain-containing protein 6 (JMJD6) is a Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenase that catalyses lysine hydroxylation and arginine demethylation of histone and non-histone peptides. Recently, the intrinsic tyrosine kinase activity of JMJD6 has also been reported. The JMJD6 has been implicated in embryonic development, cellular proliferation and migration, self-tolerance induction in the thymus, and adipocyte differentiation. Not surprisingly, abnormal expression of JMJD6 may contribute to the development of many diseases, such as neuropathic pain, foot-and-mouth disease, gestational diabetes mellitus, hepatitis C and various types of cancer. In the present review, we summarized the structure and functions of JMJD6, with particular emphasis on the role of JMJD6 in cancer progression.
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