Review
Biochemistry & Molecular Biology
Irina Gilyazova, Kadriia Enikeeva, Guzel Rafikova, Evelina Kagirova, Yuliya Sharifyanova, Dilara Asadullina, Valentin Pavlov
Summary: Bladder cancer is a common malignant tumor of the urogenital system, with over 500,000 new cases worldwide annually. Current diagnosis methods include cystoscopy and urine cytology, but they have limitations in sensitivity and invasiveness. There is a need to develop more reliable markers and tests for early detection of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
Michela Saviana, Patricia Le, Lavender Micalo, Daniel Del Valle-Morales, Giulia Romano, Mario Acunzo, Howard Li, Patrick Nana-Sinkam
Summary: There is a crosstalk between DNA methylation and miRNA expression that plays a significant role in the pathogenesis of cancer. Understanding how miRNAs influence DNA methylation and vice versa is important for identifying therapeutic targets. Additionally, these epigenetic modifications may serve as potential biomarkers in cancer.
Article
Biotechnology & Applied Microbiology
Manu Shivakumar, Seonggyun Han, Younghee Lee, Dokyoon Kim
Summary: This study provides a higher resolution of molecular insight into the crosstalk between two epigenetic factors, DNA methylation and miRNA. Results showed that these interactions are important in cancer, and it is timely to identify and understand the underlying mechanisms based on epigenetic markers and their interactions in cancer, leading to alternative splicing with primary functional impact.
Article
Oncology
Nitin Patil, Mohammed L. Abba, Chan Zhou, Shujian Chang, Timo Gaiser, Joerg H. Leupold, Heike Allgayer
Summary: Changes in methylation patterns can significantly impact the expression of miRs involved in cancer progression and metastasis, highlighting alternative mechanisms of gene regulation. Genome-wide methylation analysis in colorectal cancer revealed differential methylation of several miR genes, with implications for important cancer-related pathways. These findings suggest the importance of considering epigenetic changes in addition to genetic and transcriptional regulation of miRs in cancer.
Review
Biochemistry & Molecular Biology
Sarah S. Wang, Jihao Xu, Keely Y. Ji, Chang-Il Hwang
Summary: Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is a significant cause of cancer-related deaths in the United States. While genetic mutations driving PDA initiation and progression have been identified, the mechanisms underlying PDA metastasis remain elusive. It is suggested that epigenetic fluctuations may play a critical role in driving PDA metastasis.
Article
Cell Biology
Huimin Xu, Lingao Ju, Yaoyi Xiong, Mengxue Yu, Fenfang Zhou, Kaiyu Qian, Gang Wang, Yu Xiao, Xinghuan Wang
Summary: RNF126 is highly expressed in various cancers and acts as an oncogene in bladder cancer by promoting cell proliferation and metastasis through the EGFR/PI3K/AKT signaling pathway. It directly interacts with and regulates the stability of PTEN, an inhibitor of the PI3K/AKT pathway, through poly-ubiquitination. Knockdown of PTEN restores the effects of RNF126 silencing on cell proliferation, metastasis, and tumor formation in bladder cancer cells.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Aysegul Kutlay, Yesim Aydin Son
Summary: This study focused on identifying the regulatory impact of genetic biomarkers for monitoring metastatic molecular signatures of melanoma by investigating the consolidated effect of miRNA, mRNA, and DNA methylation. Through integrating miRNA, mRNA, and DNA methylation markers, the study found that miRNA regulation plays a significant role in metastatic melanoma, and the integrated evaluation of miRNA with mRNA and methylation biomarkers increases the model's predictive power.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lingyuan Ma, Chenyu Li, Hanlin Yin, Jiashu Huang, Shenghao Yu, Jin Zhao, Yongxu Tang, Min Yu, Jie Lin, Lei Ding, Qinghua Cui
Summary: Breast cancer is the most common cancer worldwide, and its treatment methods include radiotherapy, chemotherapy, targeted therapy, and surgery. The molecular subtype of breast cancer determines the specific treatment measures, making the exploration of molecular mechanisms and therapeutic targets essential. Abnormal methylation of tumor suppressor genes by DNMTs is associated with poor prognosis in breast cancer. MiRNAs, as non-coding RNAs, play crucial roles in breast cancer and their aberrant methylation can lead to drug resistance. Therefore, regulating miRNA methylation could be a potential therapeutic target in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
AhmadReza Rezaeian, Fatemeh Khatami, Saeed Heidari Keshel, Mohammad Reza Akbari, Akram Mirzaei, Keykavos Gholami, Reza Mohammadi Farsani, Seyed Mohammad Kazem Aghamir
Summary: This study demonstrates that MSC-exosomes have certain anti-tumor effects on prostate, bladder, and kidney cancer cells. These effects are mainly achieved by inducing apoptosis and inhibiting cancer cell proliferation.
SCIENTIFIC REPORTS
(2022)
Review
Genetics & Heredity
Mengying Zhou, Menglu Dong, Xue Yang, Jun Gong, Xinghua Liao, Qi Zhang, Zeming Liu
Summary: Breast cancer, with its high molecular heterogeneity, is the leading cause of cancer deaths in women. N6-methyladenosine (m6A), the most common mRNA internal modification in eukaryotic cells, has reversible modification process regulated by writer, reader, and eraser enzymes. Abnormal m6A modifications in breast cancer can impact key signaling pathways and serve as markers, targets, or regulators for diagnosis, prognosis prediction, and treatment.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Zhiwei Fang, Xiaoming Yang, Xiaosong Wei, Yang Yang, Chengzhi Yi, Dongkui Song
Summary: The expression of EDARADD in bladder cancer is associated with tumor malignancy and poor survival. Silencing EDARADD can inhibit the proliferation, migration, and epithelial-mesenchymal transition of bladder cancer cells, as well as repress the MAPK signaling pathway. Therefore, EDARADD may be a potential target for the treatment of bladder cancer.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Biochemistry & Molecular Biology
Qinghua Wang, Shuai Ke, Zelin Liu, Haoren Shao, Mu He, Jia Guo
Summary: Heat shock protein family A (HSP70) member 5 (HSPA5) is upregulated in bladder cancer (BCa) and correlated with patient prognosis. Knockdown of HSPA5 promotes apoptosis and inhibits proliferation, migration, and invasion of BCa cells by regulating the VEGFA/VEGFR2 signaling pathway. Moreover, HSPA5 inhibits ferroptosis through the P53/SLC7A11/GPX4 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Nikola Zmarzly, Szymon Januszyk, Pawel Mieszczanski, Emilia Morawiec, Paulina Buda, Konrad Dziobek, Marcin Oplawski, Dariusz Boron
Summary: This study found that the expression of endothelins changes in endometrial cancer, and this may be mainly due to the silencing of EDN3 activity caused by DNA methylation.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Haiyun Xie, Mingchao Wang, Haifeng Yu, Huan Wang, Lifeng Ding, Ruyue Wang, Wenqin Luo, Zeyi Lu, Qiming Zheng, Liangliang Ren, Zhenwei Zhou, Wenjing Su, Liqun Xia, Gonghui Li
Summary: The m(7)G modification is found to be present in RNA internal positions and plays a crucial role in the proliferation and metastasis of bladder cancer. METTL1 is shown to promote the processing of miR-760 in an m(7)G-dependent manner and indirectly degrade tumor suppressor ATF3 mRNA.
CELL DEATH DISCOVERY
(2022)
Article
Oncology
Xinyu Liu, Hao Zhang, Pengcheng Zhou, Yaqun Yu, Haoye Zhang, Limin Chen, Jian Gong, Zhenguo Liu
Summary: This study demonstrated that miR-922 regulates malignant behavior in liver cancer cells by targeting ARID2, with the CREB1/miR-922/ARID2 axis potentially serving as a target for liver cancer treatment.