Article
Biochemistry & Molecular Biology
Wei Gao, Xiu Wang, Yue Si, Jinlong Pang, Hao Liu, Shanshan Li, Qi Ding, Yushuai Wang
Summary: The study found that exosomes (Exo) derived from ADSCs have significant effects in preventing skin photoaging, by inhibiting DNA damage and overexpression of harmful substances through regulating multiple signaling pathways. Additionally, Exo can enhance the expression of procollagen type I and activate related pathways to protect the skin.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Min Mo, Yao Zeng, Yiqun Zeng, Shuting Li, Xiaoyang He, Xiaowen Chen, Qimei Luo, Mi Liu, Congwei Luo, Xianrui Dou, Fenfen Peng, Haibo Long
Summary: This study investigated the antifibrotic effects of NMPDOva in peritoneal fibrosis (PF) and its underlying mechanisms. NMPDOva treatment significantly alleviated PF and decreased extracellular matrix accumulation. Moreover, NMPDOva inhibited the TGF-beta 1/Smad and JAK/STAT signaling pathways to prevent PF.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Food Science & Technology
Hee Ho Song, Ki-Bae Hong, Sunhoo Kim, Byung-Yong Kim, Shin Hyung Shik, Hyung Joo Suh, Yejin Ahn
Summary: Fish collagen supplementation improves skin moisture and reduces wrinkles by regulating extracellular matrix homeostasis, reactive oxygen species and cytokine production, as well as gut microbiota composition.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Chemistry, Medicinal
Dali Ding, Xuebin Shen, Lizhen Yu, Yueyue Zheng, Yao Liu, Wei Wang, Li Liu, Zitong Zhao, Sihui Nian, Limin Liu
Summary: Timosaponin BII (TS BII), a main constituent of Anemarrhena asphodeloides Bunge, was found to restore lung structure, inhibit collagen deposition, and reverse abnormal expression of EMT-related marker proteins in a bleomycin-induced pulmonary fibrosis (PF) model. Furthermore, TS BII suppressed EMT by inhibiting the TGF-beta/Smad pathway both in vivo and in vitro. Therefore, TS BII may be a promising candidate for PF treatment.
PHYTOTHERAPY RESEARCH
(2023)
Article
Oncology
Yu Xie, Shuai Zhu, Jinglei Zang, Guanlin Wu, Yuheng Wen, Yu Liang, Ying Long, Weiming Guo, Chuanbing Zang, Xiang Hu, Gang Fan, Shuanglin Xiang, Jian Zhang
Summary: ADNP is overexpressed in BC tissues of patients with tumor progression, and high ADNP expression is associated with shorter tumor-free survival in BC patients. Downregulation of ADNP increases sensitivity to cisplatin in BC, while overexpression of ADNP has the opposite effect. ADNP promotes cell migration and EMT, leading to cisplatin resistance, possibly through the TGF-β/Smad signaling pathway.
Article
Environmental Sciences
Zeinab Rafiee, Mahmoud Orazizadeh, Fereshteh Nejad Dehbashi, Niloofar Neisi, Hossein Babaahmadi-Rezaei, Esrafil Mansouri
Summary: This study investigates the therapeutic potential of kidney stem cells (KSCs) in diabetic nephropathy (DN) and finds that KSCs significantly improve kidney function and structure in DN rats by regulating miRNA and cell signaling pathways.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Qihao Li, Wen Peng, Zhaoyu Zhang, Xin Pei, Zhongkan Sun, Yu Ou
Summary: PP20 has shown significant alleviation of inflammation and tissue destruction in pulmonary fibrosis, inhibiting EMT and reducing collagen fiber deposition. It can negatively regulate TGF-beta/Smad and MAPK pathways, showing anti-fibrotic properties.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Junju Zou, Xiaotao Zhou, Yuerong Ma, Rong Yu
Summary: The genesis and development of renal fibrosis involve various pathways related to inflammation, cytokines, oxidative stress, and metabolic abnormalities. Losartan, as a medication, can reduce renal fibrosis by regulating the TGF-beta/Smad and metabolic pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Federica Boraldi, Francesco Demetrio Lofaro, Lorena Losi, Daniela Quaglino
Summary: The study found that fragmented elastic fibers were prevalent in clinically unaffected skin of PXE patients, while calcified fibers were rarely observed. Both p-SMAD1/5/8 and p-SMAD2/3 were activated in both affected and unaffected skin.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Antonio Tejera-Munoz, Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Sandra Rayego-Mateos, Macarena Orejudo, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea, Marta Ruiz-Ortega, Raul R. Rodrigues-Diez
Summary: CCN2 plays a role in both fibrotic responses and growth factor-induced oxidative and proinflammatory responses. Its coexistence with TGF-β is necessary for persistent fibrotic response, but the mechanisms involved are not fully understood. CCN2 increases T beta RII expression in VSMCs and maintains TGF-β pathway activation through an EGFR-SMAD dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Nitwara Wikan, Saranyapin Potikanond, Wutigri Nimlamool
Summary: AP has strong inhibitory effects on TGF-beta 1-induced proliferation, migration, and myofibroblast phenoconversion of human primary dermal fibroblasts. It also blocks actin stress fiber formation and organization, leading to the inhibition of expression and production of fibrotic molecules. These findings suggest the therapeutic potential of AP for skin fibrosis.
Article
Biochemistry & Molecular Biology
Jeremy A. O'Sullivan, Frederick J. Kohlhapp, Andrew Zloza, Lourdes Plaza-Rojas, Brianna Burke, Nickolai O. Dulin, Jose A. Guevara-Patino
Summary: After exposure to an antigen, CD8 T cells make a decision to become either short-lived effector cells (SLECs) or memory progenitor effector cells (MPECs). SLECs have immediate effector function but lower lifespan and proliferative capacity compared to MPECs. TGF beta mediates the contraction phase of CD8 T cell response after infection, selectively targeting SLECs. The study aims to investigate the factors determining TGF beta sensitivity in CD8 T cell precursor stage, and the results show that SLECs are more sensitive to TGF beta than MPECs, possibly due to differential expression of TGF beta RI and RGS3 and the binding of SLEC-related transcriptional activator T-bet to the TGF beta RI promoter.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yansiwei Cheng, Yuhao Zhou, Wenjun Lv, Qing Luo, Guanbin Song
Summary: Research shows that microgravity inhibits dermal fibroblastic differentiation of BMSCs by suppressing ERK/beta-catenin signaling, indicating a potential intervention target for repairing skin injuries in microgravity conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Yali Li, Liqun Wang, Qianyu Zhang, Li Tian, Cailing Gan, Hongyao Liu, Wenya Yin, Tinghong Ye
Summary: Blueberry juice can alleviate the pathological changes and collagen deposition in idiopathic pulmonary fibrosis by suppressing epithelial-mesenchymal transition and the TGF-beta 1/Smad signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Kang Rong, Tian Wen, Cao Wei, Sun Yang, Zhang Hui-Nan, Feng Ying-Da, Li Chen, Li Ze-Zhi, Li Xiao-Qiang
Summary: LF delays liver fibrosis formation, decreases AST, ALT activities, and increases Alb activity in serum. It reduces oxidative damage, suppresses the TGF-beta/Smad signaling pathway, and plays a role in attenuating CCl4-induced liver fibrosis.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Dermatology
Jie Tang, Lidan Xiong, Xiaohong Shu, Wei Chen, Wenjia Li, Jing Li, Lianzheng Ma, Ying Xiao, Li Li
JOURNAL OF COSMETIC DERMATOLOGY
(2019)
Article
Cell & Tissue Engineering
Ru Dai, Wei Hua, Wei Chen, Lidan Xiong, Li Li, Yiming Li
STEM CELLS INTERNATIONAL
(2019)
Article
Medicine, Research & Experimental
Hailun He, Jie Tang, Dai Ru, Xionghong Shu, Wenjia Li, Jing Li, Lianzheng Ma, Xuefeng Hu, Lidan Xiong, Li Li
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Article
Allergy
Wei Hua, Ying Zuo, Ruoyu Wan, Lidan Xiong, Jie Tang, Lin Zou, Xiaohong Shu, Li Li
CONTACT DERMATITIS
(2020)
Article
Biology
Ru Dai, Wei Chen, Wei Hua, Lidan Xiong, Yiming Li, Li Li
Article
Chemistry, Applied
Xiao Li, Zeliang Wei, Xingyue Wang, Feixia Duan, Lidan Xiong, Jingwen Li, Jing Tian, Lirong Jia, Hong Gao
Summary: Premna microphylla turcz leaf juice with polysaccharides (PMPs) extracted under alkaline conditions showed remarkable radical scavenging capability, especially in inhibiting the production of inflammatory cytokines, making them a promising non-toxic natural dietary supplement.
Article
Multidisciplinary Sciences
Jiangbin Wei, Qiwu Shi, Lidan Xiong, Guang Xin, Tao Yi, Yunqing Xiao, Wanxia Huang
Summary: The study investigated the biological effects of radiation from the SG-III prototype laser facility on HaCat cells and PC12 cells, finding that the damage to cells was dose-dependent and induced DNA damage and apoptotic necrosis. Transcriptome and protein analysis revealed pathways involving proliferation, transformation, necrosis, inflammation response, apoptosis, and DNA damage repair were activated, suggesting potential harm to biological safety.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Jie Tang, Hailun He, Ruoyu Wan, Qi Yang, Heng Luo, Li Li, Lidan Xiong
Summary: A novel foundation liquid based on hemp/cellulose nanocrystals has been developed to address post-makeup skin cleaning problems, featuring easy-wiping properties that help prevent damage to the skin barrier caused by excessive cleansing. This innovative formula replaces mineral oil and titanium oxide with hemp/CNCs, creating a moisture barrier with excellent biological compatibility and water resistance. The use of discarded industrial hemp stalk to produce hemp/CNCs showcases its potential as a sustainable alternative in cosmetic research.
Review
Medicine, Research & Experimental
He Hailun, Li Anqi, Li Shiqin, Tang Jie, Li Li, Xiong Lidan
Summary: Natural antioxidants as sunscreens have gained attention due to their protective effects against UV radiation, but their mechanisms of action and potential side effects still need further investigation. Ingredients extracted from plants, animals, microorganisms, and marine organisms can enhance the SPF values of natural sunscreens, but their regulatory effects on skin inflammation, barrier impairment, and aging caused by UV exposure require more research.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Dermatology
Xuan Zheng, Li Chen, Shuguang Jin, Lidan Xiong, Huimin Chen, Ke Hu, Xueying Fan, Shijie Fan, Chenghua Li
Summary: The study found that UVB can regulate proliferative senescence of keratinocytes and photoageing of the epidermis by modulating the MM1/Delta Np63 alpha axis.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2021)
Review
Cell Biology
Qing Xiao, Lidan Xiong, Jie Tang, Li Li, Li Li
Summary: Hydrogen sulfide (H2S), along with nitric oxide (NO) and carbon monoxide (CO), is recognized as a vital gaseous transmitter, playing a unique role in regulating cellular and organ functions in both health and disease. H2S acts as an antioxidant in protecting the skin from oxidative stress, while aberrant metabolism of H2S is implicated in various skin disorders. H2S shows promise as a therapeutic intervention in skin diseases, as seen in experimental models with positive results.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Review
Medicine, Research & Experimental
Ping Diao, Hailun He, Jie Tang, Lidan Xiong, Li Li
Summary: The review highlights the mechanisms of skin damage caused by particulate matter (PM), emphasizing the effects of reactive oxygen species accumulation and autophagy, while suggesting that extracts with high antioxidant capacity from plants and natural compounds may have potential protective effects against air pollution-related skin damage.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Nanoscience & Nanotechnology
Yu Li, Qing Xiao, Jie Tang, Lidan Xiong, Li Li
Summary: Extracellular vesicles (EVs), containing DNAs, RNAs, lipids and proteins, have emerged as promising diagnostic and therapeutic agents for skin diseases. Summarizing the biological characteristics, applications, challenges and perspectives of EVs helps us better understand the potential of this novel therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Dermatology
Lingyun Zhao, Meng Hu, Qing Xiao, Runke Zhou, Yu Li, Lidan Xiong, Li Li
Summary: The systematic evaluation of the efficacy and safety of PRP in treating melasma showed promising results, indicating that PRP alone or in combination with microneedling may be an effective treatment option. Few adverse reactions were reported, supporting the safety profile of PRP use in melasma treatment.
DERMATOLOGY AND THERAPY
(2021)
