Article
Gastroenterology & Hepatology
Jaehun Yang, Jong Man Kim, Jinsoo Rhu, Gyu-Seong Choi, Choon Hyuck David Kwon, Jae-Won Joh
Summary: For resectable treatment-naive solitary HCC with Vp1-Vp3 PVTT, surgery may be a more suitable initial treatment compared to TACE-RT, as patients in the surgery group had higher survival rates and better preserved liver function.
Article
Surgery
Alexandre Chebaro, Emmanuel Buc, Thibault Durin, Laurence Chiche, Raffaele Brustia, Alexandre Didier, Francois-Rene Pruvot, Yuki Kitano, Fabrice Muscari, Katia Lecolle, Laurent Sulpice, Ercin Sonmez, Marie Bougard, Mehdi El Amrani, Daniele Sommacale, Charlotte Maulat, Ahmet Ayav, Rene Adam, Christophe Laurent, Stephanie Truant
Summary: This study compared the effects of simultaneous portal vein embolization and hepatic vein embolization techniques on remnant liver hypertrophy in candidates for extended hepatectomy, specifically LVD and ALPPS procedures. Results showed that ALPPS led to faster hypertrophy and higher successful resection rates compared to LVD. While LVD had advantages in terms of operative duration, blood losses, and length-of-stay, ALPPS demonstrated potential benefits in patient management.
Article
Gastroenterology & Hepatology
Jonathan J. Hue, Erryk Katayama, Sarah C. Markt, Luke D. Rothermel, Jeffrey M. Hardacre, John B. Ammori, Jordan M. Winter, Lee M. Ocuin
Summary: The study compared the rates of postoperative venous thromboembolism (VTE) after open hepatectomy and minimally invasive hepatectomy, finding a stronger association between open hepatectomy and VTE, with a lower VTE rate in minimally invasive hepatectomy.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ammar Sarwar, Alexei Kudla, Jeffrey L. Weinstein, Aamir Ali, Raza Malik, Andrea Bullock, Khalid O. Khwaja, Michael Curry, Salomao Faintuch, Muneeb Ahmed
Summary: This study reviewed the technical feasibility of resin microsphere yttrium-90 radioembolization using the MIRD model and found that prescribed activity calculated by MIRD was significantly higher than BSA model. The results indicated that MIRD prescribed activity with target absorbed doses up to 200 Gy can be successfully administered without prophylactic embolization in selected patients.
EUROPEAN RADIOLOGY
(2021)
Review
Medicine, General & Internal
Mariana Floria, Elena Diana Nafureanu, Diana-Elena Iov, Oana Sirbu, Mihaela Dranga, Anca Ouatu, Daniela Maria Tanase, Oana Bogdana Barboi, Vasile Liviu Drug, Mihail Dan Cobzeanu
Summary: Hereditary hemorrhagic telangiectasia is a rare autosomal dominant vascular disease characterized by mucosal and cutaneous telangiectasia and visceral arteriovenous malformations. Embolization of the afferent arteries of the malformations is the preferred treatment, and routine screening and long-term follow-up are essential.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Gianluca Cassese, Roberto Ivan Troisi, Salah Khayat, Bachir Benoudifa, Francois Quenet, Boris Guiu, Fabrizio Panaro
Summary: In this study, the medium-term outcomes of liver venous deprivation (LVD) were compared with portal vein embolization (PVE). It was found that LVD had similar peri-operative and medium-term outcomes as PVE, but had a higher growth rate and increase in future liver remnant volume.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Medicine, General & Internal
Ewa Jankowska, Iwona Bartoszuk, Katarzyna Lewandowska, Malgorzata Dybowska, Lucyna Opoka, Witold Tomkowski, Monika Szturmowicz
Summary: Acute Eosinophilic Pneumonia is a rare disease characterized by eosinophil accumulation in the lungs. Its onset is acute, and some patients may experience respiratory failure. Diagnosis is based on clinical symptoms, imaging studies, and eosinophilia in bronchoalveolar lavage or pleural fluid smear. Smokers are at an increased risk. We present a case of venous thromboembolic disease that developed during AEP in a previously healthy male smoker. The disease achieved complete remission with anticoagulation therapy and low-dose steroids. Surprisingly, further diagnostics revealed thrombophilia in the patient.
Article
Surgery
Shinji Onda, Kenei Furukawa, Koichiro Haruki, Ryoga Hamura, Yoshihiro Shirai, Jungo Yasuda, Hironori Shiozaki, Takeshi Gocho, Hiroaki Shiba, Toru Ikegami
Summary: The study aimed to evaluate a novel diagnostic algorithm using serum d-dimer levels for VTE after hepatectomy. Retrospective analysis of 742 patients showed higher incidence of VTE from 2015 to 2019, with resected liver weight >= 120 g being a significant predictor. The proposed algorithm based on d-dimer levels could aid in early diagnosis of VTE in post-hepatectomy patients.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Review
Medicine, General & Internal
Allan H. Ropper, Joshua P. Klein
Summary: Cerebral venous thrombosis is a rare complication characterized by infarction, focal neurologic deficits, increased intracranial pressure, and often accompanied by disseminated intravascular coagulation and hemorrhage, particularly observed in some Covid-19 vaccines.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Angelo Della Corte, Guido Fiorentini, Francesca Ratti, Federica Cipriani, Carla Canevari, Marco Catena, Simone Gusmini, Luigi Augello, Diego Palumbo, Giorgia Guazzarotti, Luca Aldrighetti, Francesco De Cobelli
Summary: This study presents a novel approach of combining laparoscopic liver partitioning with subsequent liver venous deprivation to prevent posthepatectomy liver failure and enhance future liver remnant volume.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2022)
Article
Medicine, General & Internal
Elena Campello, Paolo Simioni, Paolo Prandoni, Nicola Ferri
Summary: This review summarizes the clinical pharmacology and evidence from phase 2 clinical trials for drugs targeting FXI in the treatment and prevention of thrombosis, showing the potential effectiveness of FXI inhibitors without impairing hemostasis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Kevin T. Kim, Aaron P. Wessell, Jeffrey Oliver, Jason H. Boulter, Jesse A. Stokum, Cara Lomangino, Maureen Scarboro, Bizhan Aarabi, Timothy Chryssikos, Gary Schwartzbauer
Summary: This study retrospectively investigated the characteristics and outcomes of patients with tCVST after blunt head trauma, finding that patients treated with AC had significantly lower mortality rates and were more likely to experience full thrombus recanalization. These findings suggest that AC treatment may be beneficial for patients with tCVST after blunt head trauma.
Article
Surgery
Sergey G. Gavrilov, Nadezhda Yu. Mishakina, Anastasiya S. Grishenkova
Summary: This study aimed to evaluate the incidence of VTE after OVR and OVE in patients with PeVD. The results showed that the incidence of PVT after OVE was three times higher than after OVR. The importance of this study lies in providing reference for VTE prevention in the treatment of patients with PeVD.
ANNALS OF VASCULAR SURGERY
(2023)
Article
Immunology
Ludovica Baldari, Luigi Boni, Beatrice Giuliani, Elisa Cassinotti
Summary: This study aimed to evaluate the risk factors associated with the development of porto-spleno-mesenteric venous thrombosis after elective splenectomy. The results showed that spleen diameter, myeloproliferative disorder, intraoperative platelet transfusion, and intraoperative red blood cells transfusion were the main factors associated with thrombosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Crystallography
Mihai Stefan Cristian Haba, Dragomir N. Serban, Ionela Lacramioara Serban, Ivona Maria Tudorancea, Raluca Maria Haba, Minela Aida Maranduca, Daniela Maria Tanase, Radu Iliescu, Ionut Tudorancea
Summary: Cardiovascular diseases are the leading cause of death worldwide. Nanotechnology shows promise in diagnosing and treating vascular thrombotic diseases.
Article
Cardiac & Cardiovascular Systems
Anastasia Hadjivassiliou, Leandro Cardarelli-Leite, Sabeena Jalal, John Chung, David Liu, Stephen Ho, Darren Klass
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Anastasia Hadjivassiliou, Leandro Cardarelli-Leite, Sabeena Jalal, John Chung, David Liu, Stephen Ho, Darren Klass
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2020)
Review
Oncology
Howard Lim, Ravi Ramjeesingh, Dave Liu, Vincent C. Tam, Jennifer J. Knox, Paul B. Card, Brandon M. Meyers
Summary: This review discusses the use and sequencing of targeted therapy for intermediate and advanced non-LRT eligible HCC based on available phase III evidence, suggesting atezolizumab plus bevacizumab as a preferred first-line treatment option and proposing sequencing principles for later lines of treatment. Further research is needed to determine the optimal sequencing of multiple targeted therapies in this patient population.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hugo Levillain, Oreste Bagni, Christophe M. Deroose, Arnaud Dieudonne, Silvano Gnesin, Oliver S. Grosser, S. Cheenu Kappadath, Andrew Kennedy, Nima Kokabi, David M. Liu, David C. Madoff, Armeen Mahvash, Antonio Martinez de la Cuesta, David C. E. Ng, Philipp M. Paprottka, Cinzia Pettinato, Macarena Rodriguez-Fraile, Riad Salem, Bruno Sangro, Lidia Strigari, Daniel Y. Sze, Berlinda J. de Wit van der Veen, Patrick Flamen
Summary: This study established recommendations for the optimisation of selective internal radiation therapy (SIRT) with yttrium-90 (Y-90)-resin microspheres, based on expert panel discussions and survey responses from leading experts in the field. The recommendations cover various aspects of SIRT, including activity prescription, post-treatment dosimetry, and imaging for treatment verification. It is recommended that a multidisciplinary team define treatment strategy and therapeutic intent, and that a personalised approach using dosimetry be adopted for activity prescription. Additionally, post-SIRT imaging and dosimetry are strongly recommended for treatment verification and assessment.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Rebecca Ronsley, Leandro Cardarelli-Leite, Joshua Burrill, Rebecca J. Deyell, Manraj Kanwal Singh Heran
Summary: Interventional radiology has been striving to prove its value, and the research panel aims to summarize existing knowledge, identify gaps in knowledge, assess strengths and weaknesses in existing data, and prioritize research needs related to the value of IR. The research indicated that proving and quantifying how IR decreases the length of stay and prevents hospital admissions are the most critical research topics.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zersenay Alem, Timothy E. Murray, Csilla Egri, John Chung, David Liu, Khaled M. Elsayes, Silvia D. Chang, Alison Harris
Summary: Transarterial radioembolization with yttrium-90 microspheres is a well-established therapy for hepatocellular carcinoma, where post-procedural imaging plays a crucial role in assessing treatment response and potential complications. The specific imaging phenomena associated with this treatment, such as changes in tumor size and enhancement, as well as extrahepatic complications, present challenges in imaging assessment but can be better interpreted by understanding procedural steps and timelines for imaging changes. Additionally, a thorough understanding of post-procedural complications and their significance is essential for proper management.
ABDOMINAL RADIOLOGY
(2021)
Article
Oncology
Leandro Cardarelli-Leite, Shahrad Rod Rassekh, Robert D'Ortenzio, Manraj Kanwal Singh Heran
Summary: Primary and secondary malignant tumors of the spine are rare in the pediatric population but can cause high morbidity and decreased quality of life due to pain. Local management is challenging, with surgery and/or radiation therapy typically used in primary treatment. Treatment options become limited in cases of relapse or refractory disease, with vertebroplasty being a potentially underutilized modality for pain relief in relapsed cancer in the spine.
PEDIATRIC BLOOD & CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kevin S. He, Rukshan Fernando, Tatiana Cabrera, David Valenti, Abdulaziz Algharras, Nicolas Martinez, David M. Liu, Geoffroy Noel, Karl Muchantef, Ali Bessissow, Louis-Martin Boucher
Summary: The study developed a safe and technically simple liver-specific nerve block method to effectively reduce pain during liver disease treatment and reduce the risk of oversedation. Among the 12 patients who received hepatic hilar nerve block, the pain level was significantly lower compared to the control group, and the intraoperative fentanyl requirement was also reduced.
Article
Oncology
Navesh K. Sharma, S. Cheenu Kappadath, Michael Chuong, Michael Folkert, Peter Gibbs, Salma K. Jabbour, D. Rohan Jeyarajah, Andrew Kennedy, David Liu, Joshua E. Meyer, Justin Mikell, Rahul S. Patel, Gary Yang, Firas Mourtada
Summary: This article aims to develop a multidisciplinary consensus for the high-quality implementation of Yttrium-90 (90Y) microsphere brachytherapy for primary and metastatic liver cancer using transarterial radioembolization (90Y TARE). The guidelines are based on the most recent literature and clinical experience, covering indications for 90Y TARE, quality management, treatment dosimetry, and follow-up management.
Article
Surgery
David M. Liu, Thomas W. T. Leung, Pierce K. H. Chow, David C. E. Ng, Rheun-Chuan Lee, Yun Hwan Kim, Yilei Mao, Yu-Fan Cheng, Gao-Jun Teng, Wan Yee Lau
Summary: This study provides guidance and perspectives on the use of selective internal radiation therapy (SIRT) for hepatocellular carcinoma (HCC) in Asia. Through a systematic literature review and consensus approach, experts developed guidelines and recommendations for the use of SIRT in HCC patients in Asia. The study also highlights the need for further clinical trials to define the role of SIRT in managing HCC among Asian populations.
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jules Gregory, Lambros Tselikas, Caroline Allimant, Thierry de Baere, Irene Bargellini, Jon Bell, Jose Ignacio Bilbao, Antoine Bouvier, Julius Chapiro, Carlo Chiesa, Thomas Decaens, Alban Denys, Rafael Duran, Julien Edeline, Etienne Garin, Julien Ghelfi, Thomas Helmberger, Farah Irani, Marnix Lam, Robert Lewandowski, David Liu, Romaric Loffroy, David C. Madoff, Charles Mastier, Riad Salem, Bruno Sangro, Daniel Sze, Valerie Vilgrain, Michael Vouche, Boris Guiu, Maxime Ronot
Summary: This study aimed to define a textbook outcome (TO) for selective internal radiation therapy (SIRT) of hepatocellular carcinoma. The final TO, determined through expert opinions and an international survey, is a multidimensional standardization tool suitable for routine care, clinical round, and research.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Samuel S. S. Xu, Kevin Eng, Fabio Accorsi, Derek W. W. Cool, Daniele Wiseman, Amol Mujoomdar, Leandro Cardarelli-Leite
Review
Oncology
Jason K. Wong, Howard J. Lim, Vincent C. Tam, Kelly W. Burak, Laura A. Dawson, Prosanto Chaudhury, Robert J. Abraham, Brandon M. Meyers, Gonzalo Sapisochin, David Valenti, Setareh Samimi, Ravi Ramjeesingh, Amol Mujoomdar, Ilidio Martins, Elijah Dixon, Maja Segedi, David M. Liu
Summary: This article summarizes the consensus recommendations from Canadian experts on the management of intermediate-stage hepatocellular carcinoma (HCC). Through iterative feedback cycles and online surveys, consensus statements were developed in the areas of multidisciplinary treatment, intra-arterial therapy, biologics, radiation therapy, surgical resection and transplantation, and percutaneous ablative therapy. These recommendations reflect an expansion in treatment options, increased therapeutic flexibility, and a shift towards strategies with curative intent.
CANCER TREATMENT REVIEWS
(2023)
Article
Oncology
Adnan Zaidi, Shahid Ahmed, Shahida Ahmed, Bryan Brunet, Janine Davies, Corinne Doll, Dorie-Anna Dueck, Vallerie Gordon, Pamela Hebbard, Christina Kim, Duc Le, Richard Lee-Ying, Howard Lim, Dave Liu, John Paul McGhie, Karen Mulder, Jason Park, Daniel Renouf, Devin Schellenberg, Ralph P. W. Wong, Mike Moser
Summary: The Fifth Western Canadian Gastrointestinal Cancer Consensus Conference convened virtually on February 10, 2021. The conference aimed to address current issues in the management of hepatocellular cancer (HCC) and provided recommendations for the transition from local to systemic therapy and the optimal sequencing of systemic regimens for HCC.
Article
Pharmacology & Pharmacy
Marites P. Melancon, Steven Yevich, Rony Avritscher, Adam Swigost, Linfeng Lu, Li Tian, Jossana A. Damasco, Katherine Dixon, Andrea C. Cortes, Nina M. Munoz, Dong Liang, David Liu, Alda L. Tam
Summary: A novel nanoemulsion combining irinotecan with lipiodol showed higher irinotecan deposition in the liver via TACE and more irinotecan distribution in the tumor via PVCE compared to traditional delivery methods, demonstrating promising potential for the treatment of metastatic colorectal cancer.