Journal
CARBOHYDRATE POLYMERS
Volume 231, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.115727
Keywords
Cellulose membrane; TNBS assay; Carbazate stability; Carbonylated protein; Carbazate- aldehyde/ ketone coupling; Hemodialysis
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Funding
- National Key R&D Program of China [2018YFC1105900]
- Guangxi Science and Technology Base and Talent Special Project [GuikeAD17129012]
- local Science and Technology Development Project leading by the central government (the three-D printing and digital medical platform) [GuikeZY18164004]
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Carbazate groups were grafted on the commercial cellulose membrane (CM) to specifically scavenge the carbonylated proteins for hemodialysis. It confirmed that carbazate groups were successfully covalently attached on the CMs by XPS and EDS, and the modified CMs still saved their original morphology and crystalline structures by SEM and XRD. Furthermore, the modified CMs presented favorable physicochemical stability at wide pH range from 2.5 to 7.4. It was also found that the carbazate modified CMs could selectively remove carbonylated proteins from acrolein treated bovine serum albumin (BSA) or ESRD patient's blood serum in PBS buffer. The modified CMs showed the potential to be utilized as the substitute of dialysis membranes in hemodialysis.
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