Journal
CARBOHYDRATE POLYMERS
Volume 229, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.115538
Keywords
PEG-g-chitosan; in situ forming hydrogel; Schiff base; mechanics; gelation kinetics; tissue sealant
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Funding
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2017M3A9C6033875, 2018K1A4A3A01063890, 2018R1D1A1B07048522]
- National Research Foundation of Korea [2018R1D1A1B07048522] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In situ forming hydrogels generated upon spontaneous and biocompatible reaction under physiological conditions are widely investigated as injectable and implantable biomaterials. However, it is still a significant challenge to control their mechanics while maintaining their gelation behavior, due to the interdependency between gelation kinetics and mechanics. Herein, physicomechanical properties of in situ forming chitosan hydrogels via Schiff base formation are tuned in a wide range, while maintaining gelation kinetics, via polymer graft architecture. By introducing poly(ethylene glycol) (PEG) grafts with varying lengths and densities, the resulting PEG-grafted chitosan ('PEG-g-Cs') not only dissolve readily in neutral aqueous media, but also effectively control the mechanical properties of hydrogels, while maintaining facile gelation kinetics. These properties are further controlled by the chain length of polymeric crosslinker, PEG-dialdehyde. In addition, tissue adhesive properties of the hydrogels are further examined using ex vivo and in vivo models for their potential applications as tissue sealants.
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