Review
Oncology
Steven Nicolaides, Alex Boussioutas
Summary: Immunotherapy is an effective cancer treatment that activates the immune system to target and destroy cancer cells. However, the use of immune checkpoint inhibitors is often limited by immune-related adverse events. This review focuses on the management and emerging therapies for immune-related adverse events in the gastrointestinal system.
Review
Endocrinology & Metabolism
Alexandra Chera, Andreea Lucia Stancu, Octavian Bucur
Summary: Immune checkpoint inhibitors are effective in cancer treatment, but can lead to immune-related adverse events, including thyroid dysfunction. Early prediction and detection of these events are crucial, as they can serve as prognostic markers and indicators of treatment response.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Christopher A. Muir, Roderick J. Clifton-Bligh, Georgina Long, Richard A. Scolyer, Serigne N. Lo, Matteo S. Carlino, Venessa H. M. Tsang, Alexander M. Menzies
Summary: Thyroid dysfunction is common following immune checkpoint inhibition, with different subtypes of thyroid immune-related adverse events having unique clinical and biochemical associations. Overt thyrotoxicosis was associated with longer progression free survival and overall survival, while hypothyroidism showed no association with cancer outcomes. Multiple distinct phenotypes of thyroid irAEs suggest potentially different etiologies for thyrotoxicosis and hypothyroidism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Christopher A. Muir, Roderick J. Clifton-Bligh, Georgina V. Long, Richard A. Scolyer, Serigne N. Lo, Matteo S. Carlino, Venessa H. M. Tsang, Alexander M. Menzies
Summary: Thyroid dysfunction is common following immune checkpoint inhibition, with distinct phenotypes of thyroid irAEs showing unique clinical and biochemical associations. Overt thyrotoxicosis was associated with longer survival outcomes, while no association was found between hypothyroidism and cancer outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Christopher A. Muir, Venessa H. M. Tsang, Alexander M. Menzies, Roderick J. Clifton-Bligh
Summary: The translated article introduces immune checkpoints, immune checkpoint inhibitors, and the association of thyroid dysfunction with immune-related adverse events (irAEs). Thyroid irAEs may be associated with increased immune toxicity in other organ systems and longer progression-free and overall survival.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
T. Anders Olsen, Tony Zibo Zhuang, Sarah Caulfield, Dylan J. Martini, Jacqueline T. Brown, Bradley C. Carthon, Omer Kucuk, Wayne Harris, Mehmet Asim Bilen, Bassel Nazha
Summary: Immune-oncologic therapy has revolutionized cancer treatment, but immune-related adverse events (irAEs) can occur as side effects. irAEs are major consequences of checkpoint inhibitors and significantly impact a patient's cancer treatment and quality of life. Therefore, it is important to manage irAEs using a similar approach to autoimmune diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Ning Jiang, Yue Yu, Dawei Wu, Shuhang Wang, Yuan Fang, Huilei Miao, Peiwen Ma, Huiyao Huang, Min Zhang, Yu Zhang, Yu Tang, Ning Li
Summary: This review provides a current understanding of the role of HLAs in cancer immunology. It summarizes how HLA alterations contribute to immune escape and resistance to immunotherapy, and potential methods to overcome HLA defects. The review also discusses the potential association between HLA and immune-related adverse events (irAEs). Downregulation, loss of heterogeneity, and entire loss of HLAs are responsible for immune escape. Overcoming HLA defects can be effective in cancer therapy. Non-classical HLA-I molecules, such as HLA-E and HLA-G, are reliable predictors of prognosis, while classical HLA-I expression is a potential predictor of favorable immunotherapy response. Certain HLA types may be associated with enhanced affinity to self-antigen-mimicked tumor antigens, which may positively correlate with irAEs triggered by checkpoint inhibitors.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang
Summary: Immunotherapy has revolutionized cancer treatment, with immune checkpoint inhibitors being the most successful agents, but they come with a risk of immune-related adverse events. The mechanisms of ICIs and irAEs have been discussed, and the comprehensive summary focuses on unresolved challenges and intriguing issues in this field.
FRONTIERS OF MEDICINE
(2021)
Article
Oncology
Nilasha Ghosh, Michael Postow, Chengsong Zhu, Deanna Jannat-Khah, Quan-Zhen Li, Greg Vitone, Karmela K. Chan, Anne R. Bass
Summary: Immune checkpoint inhibitors have shown success in treating advanced cancers but can also lead to immune-related adverse events (irAE). This study investigated the association between baseline autoantibodies and irAE development in patients receiving ICI therapy for melanoma. Results showed that lower autoantibody concentrations at baseline and a greater change in antibody concentration over time were associated with organ-specific irAE. Further research is needed to understand the role of autoantibodies in the pathogenesis of irAE.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Amanda C. Guidon, Leeann B. Burton, Bart K. Chwalisz, James Hillis, Teilo H. Schaller, Anthony A. Amato, Allison Betof Warner, Priscilla K. Brastianos, Tracey A. Cho, Stacey L. Clardy, Justine Cohen, Jorg Dietrich, Michael Dougan, Christopher T. Doughty, Divyanshu Dubey, Jeffrey M. Gelfand, Jeffrey T. Guptill, Douglas B. Johnson, Vern C. Juel, Robert Kadish, Noah Kolb, Nicole R. LeBoeuf, Jenny Linnoila, Andrew L. Mammen, Maria Martinez-Lage, Meghan J. Mooradian, Jarushka Naidoo, Tomas G. Neilan, David A. Reardon, Krista M. Rubin, Bianca D. Santomasso, Ryan J. Sullivan, Nancy Wang, Karin Woodman, Leyre Zubiri, William C. Louv, Kerry L. Reynolds
Summary: This study aimed to develop consensus guidance and definitions for irAE-Ns, using a modified Delphi consensus process and the RAND/University of California Los Angeles Appropriateness Method, resulting in consensus definitions for seven core disorders. These definitions standardized irAE-N classification, providing guidance for clinical and research settings.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Kathleen M. Capaccione, Jacienta P. Valiplackal, Alice Huang, Tina Roa, Alana Fruauff, Connie Liou, Eleanor Kim, Sakshi Khurana, Mary Maher, Hong Ma, Pamela Ngyuen, Serena Mak, Shifali Dumeer, Sonali Lala, Belinda D'souza, Sherelle Laifer-Narin, Elise Desperito, Carrie Ruzal-Shapiro, Mary M. Salvatore
Summary: Cancer immunotherapies modulate the body's immune system to enhance immune response against cancer. However, immune-related adverse events (IRAEs) can result from these therapies, making it crucial for radiologists to recognize and manage them effectively.
ACADEMIC RADIOLOGY
(2022)
Article
Oncology
Chiara Pozzessere, Romain Lazor, Raphael Jumeau, Solange Peters, John O. Prior, Catherine Beigelman-Aubry
Summary: Pulmonary immune-related adverse events are rare but potentially severe side effects of immunotherapies. Accurate imaging evaluation is essential for prompt detection and correct management.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Christopher A. Muir, Cameron C. G. Wood, Roderick J. Clifton-Bligh, Georgina Long, Richard A. Scolyer, Matteo S. Carlino, Alexander M. Menzies, Venessa H. M. Tsang
Summary: This study found that positivity for TPOAb and TgAb at baseline was more prevalent in patients who developed thyroid irAEs, particularly overt thyrotoxicosis. During ICI treatment, significant increases in TgAb and TPOAb titers were associated with overt thyrotoxicosis. TPOAb and TgAb positivity or increases during ICI treatment may be a useful biomarker to identify patients at increased risk of thyroid irAEs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Jared Ostmeyer, Jason Y. Park, Mitchell S. von Itzstein, David Hsiehchen, Farjana Fattah, Mary Gwin, Rodrigo Catalan, Shaheen Khan, Prithvi Raj, Edward K. Wakeland, Yang Xie, David E. Gerber
Summary: The baseline T-cell tolerant fraction may serve as a predictor of clinically significant immune-related adverse events (irAEs) among patients receiving immune checkpoint inhibitor (ICI) therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Dermatology
Anusuya Kawsar, Charlotte Edwards, Pooja Patel, Richard M. Heywood, Aakriti Gupta, Jasmine Mann, Christopher Harland, Kara Heelan, James Larkin, Paul Lorigan, Catherine A. Harwood, Rubeta N. Matin, Louise Fearfield
Summary: This multicentre observational study investigates the incidence and characteristics of bullous cutaneous immune-related adverse events (irAEs) associated with checkpoint inhibitor (CPI) therapy. The study finds that these irAEs are rare but can occur after cessation of treatment, and discontinuation of CPIs may be necessary for management. Prompt recognition and referral to dermatology are crucial for optimal management and patient outcomes.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Shohei Kishimoto, Hideyuki Sasaki, Seigo Kurisu, Kenichi Ogawa, Shohei Matsuno, Hiroto Furuta, Mikio Arita, Keigo Naka, Kishio Nanjo, Takashi Akamizu
Summary: The study aimed to clarify the relationship between extensor digitorum brevis muscle atrophy (EDBA) and symmetric polyneuropathy (SPN), especially diabetic SPN (DSPN). EDBA detection may be a useful method for screening for distal symmetric polyneuropathy, particularly DSPN in men, and may be associated with factors like aging, traditional sitting styles, and known diabetes. Further research is needed to improve the accuracy of diagnosing SPN/DSPN through EDBA detection.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Chie Kitahara, Shuhei Morita, Shohei Kishimoto, Shohei Matsuno, Shinsuke Uraki, Ken Takeshima, Yasushi Furukawa, Hidefumi Inaba, Hiroshi Iwakura, Hiroyuki Ariyasu, Hiroto Furuta, Masahiro Nishi, Takashi Akamizu
Summary: This is the first reported case of intraoperatively detected euglycemic diabetic ketoacidosis associated with sodium-glucose cotransporter 2 inhibitors during thoracic surgery. Early identification and management are crucial for rapid recovery.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Rheumatology
Hisanori Umehara, Kazuichi Okazaki, Shigeyuki Kawa, Hiroki Takahashi, Hiroshi Goto, Shoko Matsui, Nobukazu Ishizaka, Takashi Akamizu, Yasuharu Sato, Mitsuhiro Kawano
Summary: IgG4-related disease is a clinical entity comprising various diseases, and the Japanese team has updated the comprehensive diagnostic criteria to address issues such as biopsy sample difficulties and specificity in IgG4 levels. The 2020 revised criteria include three main domains and new pathological diagnosis sub-items.
MODERN RHEUMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Shuhei Morita, Yoko Inai, Shiho Minakata, Shohei Kishimoto, Shino Manabe, Naoyuki Iwahashi, Kazuhiko Ino, Yukishige Ito, Takashi Akamizu, Yoshito Ihara
Summary: C-Mannosyl tryptophan (CMW) has been identified as a potential novel biomarker for evaluating renal function and predicting disease progression in patients with type 2 diabetes. A new quantification method was established for serum CMW, showing stronger correlations with serum creatinine, cystatin C, and eGFR compared to other markers. Additionally, higher levels of serum CMW were associated with a history of macroangiopathy and peripheral arterial disease, indicating its potential utility in assessing renal function and vascular complications in type 2 diabetes patients.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Shohei Kishimoto, Shuhei Morita, Chiaki Kurimoto, Chie Kitahara, Tomoya Tsuji, Shinsuke Uraki, Ken Takeshima, Yasushi Furukawa, Hiroshi Iwakura, Hiroto Furuta, Masahiro Nishi, Taka-Aki Matsuoka
Summary: This is a case report of lymphoma with unique clinical courses initially presenting hypopituitarism and symptoms mimicking Tolosa-Hunt syndrome, accompanied by a mass in the sphenoidal and cavernous sinuses and erosion of the sphenoid bone.
BMC ENDOCRINE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Shuhei Morita, Tomoya Tsuji, Shohei Kishimoto, Shinsuke Uraki, Ken Takeshima, Hiroshi Iwakura, Hiroto Furuta, Masahiro Nishi, Hidefumi Inaba, Taka-aki Matsuoka
Summary: This article reports the first case of isolated adrenocorticotropic hormone (ACTH) deficiency potentially associated with COVID-19 immunization. It highlights the importance of adjuvants in mRNA vaccines in inducing endocrinological adverse effects through disturbance of the autoimmune system.
BMC ENDOCRINE DISORDERS
(2022)
Article
Oncology
Mitsuyoshi Hirokawa, Hirohiko Niioka, Ayana Suzuki, Masatoshi Abe, Yusuke Arai, Hajime Nagahara, Akira Miyauchi, Takashi Akamizu
Summary: This study demonstrates the accuracy of AI-based image analysis for thyroid fine-needle aspiration cytology (FNAC) and suggests its potential application in clinical practice. The AI training showed high precision-recall area under the curve (PR AUC) for most types of thyroid nodules, except for poorly differentiated thyroid carcinoma and medullary thyroid carcinoma. The analysis could be useful for improving the clinical management of AUS and follicular neoplasm nodules.
CANCER CYTOPATHOLOGY
(2023)
Article
Medicine, General & Internal
Hidefumi Inaba, Yosuke Kaido, Daisuke Kosugi, Yuki Asai, Shinya Ogino, Shogo Nakano, Saya Ito, Tomonao Hirobata, Kazuo Ono, Kosuke Minaga, Shuhei Morita, Gen Inoue
Summary: A 43-year-old man presented with headache, dizziness, abdominal pain, and vomiting. His laboratory findings revealed elevated creatinine and lipase levels, low calcium level, and hypertriglyceridemia and hyperglycemia. Imaging showed interstitial pneumonia, severe pancreatitis, and an adrenal tumor. The patient also experienced vertebral artery dissection and medullary infarction. Diagnosis of pheochromocytoma multisystem crisis (PMC) was made after right adrenalectomy. Acute pancreatitis can exacerbate the life-threatening manifestations of PMC.
Article
Biochemistry & Molecular Biology
Hideki Kosako, Yusuke Yamashita, Shuhei Morita, Sadahiro Iwabuchi, Shinichi Hashimoto, Taka-Aki Matsuoka, Takashi Sonoki, Shinobu Tamura
Summary: This study found that activation of the endoplasmic reticulum stress pathway through modulation of c-Abl protein conformation can have anti-myeloma effects. Asciminib, a new allosteric c-Abl inhibitor, decreased cell viability and induced cell death in myeloma cells. This research provides a novel therapeutic target and potential treatment for multiple myeloma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Shuhei Morita, Tomoyuki Takagi, Hidefumi Inaba, Yasushi Furukawa, Shohei Kishimoto, Shinsuke Uraki, Naoki Shimo, Ken Takeshima, Saya Uraki, Kei Doi, Mitsuyo Imagawa, Mika Kokawa, Tomomi Konami, Hitomi Hara, Yoshihiro Hara, Emiko Sone, Hiroto Furuta, Masahiro Nishi, Asako Doi, Shinobu Tamura, Taka-aki Mastuoka
Summary: This study investigated the impact of the SARS-CoV-2 vaccine on thyroid autoimmunity and found that the vaccine may disrupt thyroid autoimmunity. Clinicians should consider this possibility.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pathology
Aki Tanaka, Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Akira Miyauchi, Takashi Akamizu
Summary: The study aimed to explore the clinical, cytological, and pathological characteristics of metastatic renal cell carcinoma to the thyroid (MRCCT). 14 MRCCT cases were included in the study, with 85.7% occurring as solitary lesions on ultrasonography. Cytology showed that 46.2% of cases were reported as RCC or suspected RCC, and a long interval from the initial presentation, occurrence as a solitary lesion, and low Ki-67 labeling index were associated with longer disease-free survival.
PATHOLOGY INTERNATIONAL
(2023)
Article
Immunology
Hidefumi Inaba, Shuhei Morita, Daisuke Kosugi, Yuki Asai, Yosuke Kaido, Saya Ito, Tomonao Hirobata, Gen Inoue, Yuki Yamamoto, Masatoshi Jinnin, Hiroaki Kimura, Masao Ota, Yuko Okudaira, Hiroyasu Nakatani, Tomoko Kobayashi, Shintaro Iwama, Hiroshi Arima, Takaaki Matsuoka
Summary: Immune-checkpoint inhibitors are effective in various advanced cancers, but the immunological mechanism behind the serious complication of ICI-T1DM is unclear.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medical Laboratory Technology
Naoki Yamao, Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Tomo Ishisaka, Akira Miyauchi, Takashi Akamizu
Summary: This study describes the unique features of medullary thyroid carcinoma (MTC) with papillary-like nuclear features and investigates their prognostic value as markers of high-grade MTC.
DIAGNOSTIC CYTOPATHOLOGY
(2023)
Article
Endocrinology & Metabolism
Ken Takeshima, Yaqiong Li, Kennichi Kakudo, Mitsuyoshi Hirokawa, Eijun Nishihara, Akira Shimatsu, Yutaka Takahashi, Takashi Akamizu
Summary: Patients with IgG4-related thyroid disease (IgG4-RTD) are diagnosed based on five criteria, including thyroid enlargement, hypoechoic lesions on ultrasound, elevated serum IgG4 levels, histopathological findings, and involvement of other organs. These criteria help ensure accurate diagnosis of IgG4-RTD and can aid in differentiating it from other conditions.
